Expression and significance of COX-2 and VEGF in adenomyosis

Objective To discuss the expression of Cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF) in adenomyosis and its clinical significance.Methods Using immunohistochemistry SP method,the expression of COX2 and VEGF was examined in ectopic endometrium and eutopic endometrium,compared with normal endometrium.Results ①VEGF could be expressed either in endometriumal glands or stromal cells.VEGF expressions in ectopic,eutopic endometrium with adenomyosis were both significantly higher than that of control group(P0.05);no statistically significant difference was found between ectopic endometrium and eutopic endometrium group(P0.05).②COX-2 could be expressed either in endometriumal glands or stromal cells.COX-2 expression in ectopic,eutopic endometrium with adenomyosis was significantly higher than that in control group(P0.05).No statistically significant difference was found between ectopic endometrium and eutopic endometrium group with adenomyosis(P0.05).③VEGF and COX-2 had the positive relativity in the ectopic endometriumal expression of adenomyosis patient(P0.05).Conclusion COX-2 and VEGF are important cellular factors of promoting vascular formation.Data demonstrate that they could probably play important roles in the pathogenesis of adenomyosis.