Meta-analysis of the effects of carbon nanoparticles on parathyroid glands during thyroid papillary carcinoma surgery

Abstract Backgroud：carbon nanoparticles suspension injection is a commonly used lymph node tracer in thyroid tumor surgery. Its effect on the parathyroid gland is still unclear. Therefore, this paper attempted to evaluate the effect of the application of carbon nanoparticles in thyroid cancer surgery on the parathyroid gland by meta-analysis. Method：Literature retrieved from the Cochrane Library, Embase, PubMed, Sinomed, CNKI and Wanfang databases was reviewed. Retrieved December 1, 2022. The outcome measures included as effective measures were relative risk (RR) and 95% confidence interval (CI). For data analysis, Stata 15.0 software is employed. Results: A total of 14 studies were included in this meta-analysis. 1117 patients with papillary carcinoma of thyroid were treated with carbon nanoparticles during surgery, and 997 patients were treated with conventional surgery without carbon nanoparticles. The results showed that compared with conventional surgery, the application of nano carbon can reduce the parathyroid gland misincision and reduce the incidence of postoperative hypocalcemia. (RR=0.42,95%CI 0.35-0.5,P < 0.00001). Conclusions: The use of carbon nanoparticles in the treatment of thyroid papillary carcinoma is advantageous for parathyroid gland protection.