Reply: Is the dose to inhibit the COX-2 enzyme in nude mice also adequate in human endometrial tissues?

M. Louise Hull, D. Stephen Charnock‐Jones
In: Human Reproduction · 2005 · vol. 20(9) , pp. 2665–2666 · doi:10.1093/humrep/dei115 · W2141309965
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This letter questions the evidence for commonly accepted plausibility regarding COX-2 inhibition doses in mice and human tissues, drawing a parallel to the unproven theory of double ovulation in dizygotic twinning.

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Abstract

some obvious plausibility, as witness the fact that many critically intelligent people believe it (as I did until it mattered to me and I looked for the evidence). It is apparently so very plausible that no one has bothered to prove it (or to pay attention to such evidence to the contrary as is available in the very references included with these letters). This is much like the legendary double-ovulation origin of natural human dizygotic twinning (Boklage, 2005).

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