Effect of the Levonorgestrel-Releasing Intrauterine System on the Uterine Artery, Uterine Volume, and Endometrium in Endometrial Hyperplasia without Atypia

İlkbal Temel Yüksel, Baki Erdem, Berna Aslan Çetin, Nadiye Köroğlu, Ramazan Dansuk
In: Journal of Academic Research in Medicine · 2019 · vol. 9(-1) , pp. 15–18 · doi:10.5152/jarem.2019.2470 · W2923114128
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study evaluated the effects of the levonorgestrel-releasing intrauterine system on endometrial thickness, hemogram parameters, and uterine artery Doppler results in women with endometrial hyperplasia without atypia.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This prospective study evaluated 54 women with endometrial hyperplasia without atypia and menorrhagia treated with a levonorgestrel-releasing intrauterine system, assessing uterine artery Doppler indices, uterine volume, hemogram parameters, and follow-up endometrial biopsy findings after 6 months. Of 50 women who completed follow-up, endometrial hyperplasia regressed, while uterine artery resistance index and pulsatility index and uterine volume showed no significant change. The authors reported reduced endometrial thickness and increased hemoglobin and hematocrit concentrations. This paper is centrally about adenomyosis? No—this paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Objective: The aim of this study is to evaluate the effects of the levonorgestrel-releasing intrauterine system (LR-IUS) on endometrial thickness, hemogram parameters, and uterine artery Doppler results among women who have endometrial hyperplasia without atypia.
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Abstract

Objective: The aim of this study is to evaluate the effects of the levonorgestrel-releasing intrauterine system (LR-IUS) on endometrial thickness, hemogram parameters, and uterine artery Doppler results among women who have endometrial hyperplasia without atypia.

Methods

Fifty-four women who admitted to our hospital due to menorrhagia and with a diagnosis of endometrial hyperplasia without atypia treated with the LR-IUS were included in our study. The uterine artery measurements, uterine volume, alterations on hemoglobin concentrations, and follow-up endometrial biopsies after 6 months were analyzed.

Results

Fifty women completed the 6-month period. Among all these women, regression was recorded in endometrial hyperplasia. The uterine artery resistance index, pulsatility index, and uterine volume did not show any significant difference. Reduction in the endometrial thickness and increasing levels of hemoglobin and hematocrit concentrations were also determined.

Conclusion

LR-IUS may be used as an effective procedure and a confident alternative medical approach to oral gestagen therapy and surgery among women with menorrhagia who have simple endometrial hyperplasia without atypia.

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