Therapiekonzept der schweren Endometriose (rAFS Grad IV): Rezidivhäufigkeit und postoperative Schwangerschaftsrate nach mikrochirurgischen Sterilitätslaparotomie und prä- bzw. postoperativer (anti)hormoneller Therapie
This study investigated recurrence rates and pregnancy outcomes following microsurgical laparotomy for severe endometriosis (rAFS Grade IV) with varying hormonal therapy regimens.
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The study evaluated 78 women with severe endometriosis (revised AFS grade IV) treated between 1999 and 2002 with micro-surgical sterility laparotomy, assessing how pre- and postoperative (anti)hormonal therapy related to recurrence frequency and postoperative pregnancy outcomes. Using follow-up contact of 52 patients at least 2 years after surgery, preoperative therapy depended on baseline findings while intraoperative findings determined postoperative therapy; the cohort included both women operated mainly for endometriosis-related symptoms and those with infertility as the main indication. Overall postoperative pregnancy rate was 42.3% (72.7% spontaneous conception, 27.3% IVF), and 73.1% were recurrence-free after at least 2 years, with higher recurrence-free rates (78.9%) in the symptom-driven subgroup. A key limitation explicitly reflected in the methods is the small, non-complete follow-up sample (52 of 78 contacted). This paper is centrally about endometriosis — it analyzes relapse and pregnancy rates after surgery with pre-/postoperative hormonal therapy in rAFS IV° severe disease.
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