Gamma Delta T Cells in Glioblastoma Multiforme: Novel Roles and Therapeutic Opportunities

Glioblastoma multiforme (GBM) is one of the most aggressive cancers, with limited treatment options due to its immunosuppressive microenvironment. γδ T cells, known for their potent antitumor activity and ability to recognize tumor antigens independently of HLA molecules, have emerged as a promising therapeutic strategy. This review explores the role of γδ T cells in glioblastoma, focusing on their functional plasticity and potential to overcome immune evasion mechanisms. We also discuss potential combinatory approaches to enhance the therapeutic effectiveness of γδ T cell-based strategies in GBM treatment.