The Peculiarities of Local Immunity, the Level of Cytokines and Growth Factors in Endometrioid Ovarian Cysts Depending on the Presence or Absence of Undifferentiated Dysplasia of Connective Tissues

In the peritoneal microenvironment level, in patients with endometrioid ovarian cysts develop immunological dysfunction, which is characterized by increased activity of macrophages and decreased activity of T-lymphocytes and natural killer cells. Certain changes are exacerbated in patients with both endometrioid ovarian cysts and undifferentiated dysplasia of connective tissue, such as a decrease in the number of peritoneal fluid lymphocyte CD4-, CD16-, CD25- lymphocytes and B lymphocytes. In patients with endometrioid ovarian cysts combined with undifferentiated dysplasia of connective tissues, have increased levels of proinflammatory cytokines which promotes a proangiogenic effect: IL1 , TNF , IL6, IL8. In addition, when endometrioid ovarian cysts are concomitant with undifferentiated dysplasia of connective tissues the level of antitumor cytokine IL2 and IFN are decreased. Similar changes in the cytokine composition of the peritoneal fluid, along with reduction of the number of immunocompetent cells with antitumor cytotoxicity determine the increase of proangiogenic and decrease of antitumor activity.