Effects of dexmedetomidine on inflammatory response and oxidative stress in laparoscopic hysterectomy patients

Objective: To investigate the effect of dexmedetomidine on inflammatory response and \noxidative stress in patients with laparoscopic total hysterectomy. Methods: Ninety patients with \nlaparoscopic hysterectomy under general anesthesia were selected in our hospital from January \n2015 to December 2016, and randomly divided into control group and observation group, \nEach group of 45 cases. The observation group was given dexmedetomidine, intravenous \npump injection, The control group was given the same amount of saline in the same manner, \nfollowed by anesthesia induction. The hemodynamics, inflammatory factors and oxidative \nstress were monitored before anesthesia (T0), 30 min after the end of pneumoperitoneum (T1), \nafter operation (T2) and at the end of 24 h (T3). Results: Compared with T0, T1, T2 and T3, \nthe observation group of patients with MAP and HR levels were no significant difference;T3, \nthe control group MAP and HR levels were not significantly different; T1 and T2, MAP and \nHR levels in the control group were significantly increased, And significantly higher than \nthe observation group; Compared with T0, the levels of CRP, TNF-α and IL-1β in patients \nwere significantly increased in T1, T2 and T3, but the levels of CRP, TNF-α and IL-1β in \nthe observation group were significantly lower than those in the control group; Compared \nwith T0, both groups of patients with H 2 O 2 and MDA levels were significantly increased, TAS \nlevels were significantly reduced, the difference was statistically significant, However, the \nlevels of H 2 O 2 and MDA in the observation group were significantly lower than those in the \ncontrol group, the level of TAS was significantly higher than the control group. Conclusion: \nLaparoscopic hysterectomy increases the inflammatory response and oxidative stress in \npatients, while the use of dexmedetomidine can maintain hemodynamic stability in a certain \nextent, reduce the inflammatory response and reduce oxidative stress injury; it is worth of \nfurther clinical application.