Leucocyte adherence inhibition for detecting specific tumour immunity in early pancreatic cancer

D N Tataryn, Tataryn DN, J K MacFarlane, MacFarlane JK, D M Thomson, Thomson DM
Lancet (London, England) · 1978 · vol. 1(8072) , pp. 1020–2 · doi:10.1016/s0140-6736(78)90742-0 · PMID:76938
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The automated tube leucocyte-adherence inhibition assay detected tumour-specific immunity to pancreatic antigens in patients with localised and extensive pancreatic cancer, while showing no reactivity to antigens from other gastrointestinal or lung malignancies.

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Abstract

Tumour-specific immunity to pancreatic tumour antigens, assayed by an automated tube leucocyte-adherence inhibition assay (L.A.I.), was detected in 3 of 3 patients with localised pancreatic cancer and 3 of 8 patients with more extensive pancreatic cancer. Leucocytes from pancreatic cancer patients with L.A.I. reactivity did not react to antigens of stomach, colon, or lung tumours; leucocytes from patients with stomach, colon, or lung cancer of inflammatory disease of the pancreas and bowel did not show L.A.I. reactivity to pancreatic tumour antigens.

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MeSH descriptors

Adenoma, Islet Cell Leukocytes Pancreatic Neoplasms Adenoma, Islet Cell Adenoma, Islet Cell Antigens, Neoplasm Colonic Neoplasms Colonic Neoplasms Humans Leukocytes Lung Neoplasms Lung Neoplasms Pancreatic Cyst Pancreatic Cyst Pancreatic Neoplasms Pancreatic Neoplasms Pancreatitis Pancreatitis Stomach Neoplasms Stomach Neoplasms

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