Severity of small-for-gestational age and morbidity and mortality among very preterm neonates

Severity of small-for-gestational age and morbidity and mortality among very preterm neonates | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Severity of small-for-gestational age and morbidity and mortality among very preterm neonates Kathleen Minor, Katherine Bianco, Lillian Sie, Maurice Druzin, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1871875/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 27 Oct, 2022 Read the published version in Journal of Perinatology → Version 1 posted 9 You are reading this latest preprint version Abstract Objective: Evaluate the association between small for gestational age (SGA) severity and morbidity and mortality in a contemporary, unselected population of very preterm infants. Study Design: This secondary analysis of a California statewide database evaluated singleton infants born during 2008-2018 at 24-32 weeks’ gestation, with a birthweight <15th percentile. We analyzed neonatal outcomes in relation to weight for gestational age (WGA) and symmetry of growth restriction. Results: An increase in WGA by one z-score was associated with decreased major morbidity or mortality risk (aRR 0.73, 95% CI 0.68-0.77) and other adverse outcomes. The association was most pronounced for WGA percentile <3 and did not differ by fetal growth restriction diagnosis. Symmetric growth restriction was not associated with neonatal outcomes after standardizing for gestational age at birth. Conclusions: Increasing SGA severity, particularly below the 3rd WGA percentile, had a significant impact on neonatal outcomes among very preterm infants. Full Text Additional Declarations There is NO conflict of interest to disclose. Supplementary Files Figure2.pdf SUPPLEMENTARY INFORMATION: FIGURE: Cohort selection File type: pdf Cite Share Download PDF Status: Published Journal Publication published 27 Oct, 2022 Read the published version in Journal of Perinatology → Version 1 posted Editorial decision: revise 03 Aug, 2022 Review # 1 received at journal 02 Aug, 2022 Review # 2 received at journal 29 Jul, 2022 Reviewer # 2 agreed at journal 28 Jul, 2022 Reviewer # 1 agreed at journal 21 Jul, 2022 Reviewers invited by journal 20 Jul, 2022 Submission checks completed at journal 19 Jul, 2022 Editor assigned by journal 18 Jul, 2022 First submitted to journal 18 Jul, 2022 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1871875","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":122680095,"identity":"012d2a7f-3233-40d4-b088-9122a3e43029","order_by":0,"name":"Kathleen 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We analyzed neonatal outcomes in relation to weight for gestational age (WGA) and symmetry of growth restriction. \u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e An increase in WGA by one z-score was associated with decreased major morbidity or mortality risk (aRR 0.73, 95% CI 0.68-0.77) and other adverse outcomes. The association was most pronounced for WGA percentile \u0026lt;3 and did not differ by fetal growth restriction diagnosis. 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