Potential of interval training protocol on a short-arm human centrifuge for orthostatic intolerance prevention after space flight conditions

Potential of interval training protocol on a short-arm human centrifuge for orthostatic intolerance prevention after space flight conditions | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Potential of interval training protocol on a short-arm human centrifuge for orthostatic intolerance prevention after space flight conditions Maria Vladimirovna Fedchuk, Vasily Borisovich Rusanov, Milena Ilinichna Koloteva, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6321692/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 10 May, 2025 Read the published version in Microgravity Science and Technology → Version 1 posted 9 You are reading this latest preprint version Abstract The decrease in orthostatic tolerance due to the deconditioning of cardiovascular system after space flight remains an urgent problem. The effect of longitudinal overloads on a short-arm human centrifuge (SAHC) is believed to be useful in preventing a decrease in orthostatic tolerance in astronauts after spaceflight through regular compensation of hydrostatic blood pressure, which is absent in microgravity. The analysis of adaptive reactions of the autonomic regulation system was carried out by analyzing heart rate variability, blood pressure was used to calculate hemodynamic parameters. These characteristics were analyzed in 6 male subjects (mean age 38 ± 7 (SD) years) during the protocol of training rotations on the SAHC and during a passive orthostatic test with foot support (tilt test). The nonparametric Wilcoxon criterion and Kendall's rank correlation coefficient were used for statistical analysis. During training rotations, an increase in heart rate (HR), a weakening of high-frequency (HF) and a significant increase in low-frequency (LF) spectral components of the heart rate were observed, indicating the involvement of the sympatho-vagal system with a predominance of sympathetic regulation. It is shown that after a series of rotations on the SAHC, there is a smaller increase in HR in an upright position during a tilt test, which indicates a decrease in excitability and reactivity of the sympathetic nervous system. There was also a decrease in the influence of supra-segmental (higher) autonomic centers on the regulation processes during orthostatic loading. This interval training protocol on the SAHC has a training effect and increases orthostatic stability. artificial gravity short-radius centrifuge heart rate variability interval training protocol regulation mechanisms orthostatic tolerance average dynamic pressure Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 10 May, 2025 Read the published version in Microgravity Science and Technology → Version 1 posted Editorial decision: Revision requested 17 Apr, 2025 Reviews received at journal 17 Apr, 2025 Reviews received at journal 08 Apr, 2025 Reviewers agreed at journal 06 Apr, 2025 Reviewers agreed at journal 04 Apr, 2025 Reviewers invited by journal 03 Apr, 2025 Editor assigned by journal 31 Mar, 2025 Submission checks completed at journal 31 Mar, 2025 First submitted to journal 27 Mar, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6321692","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":444277051,"identity":"57234623-c293-4098-a56e-556263ad54f1","order_by":0,"name":"Maria Vladimirovna 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The effect of longitudinal overloads on a short-arm human centrifuge (SAHC) is believed to be useful in preventing a decrease in orthostatic tolerance in astronauts after spaceflight through regular compensation of hydrostatic blood pressure, which is absent in microgravity.\u003c/p\u003e \u003cp\u003eThe analysis of adaptive reactions of the autonomic regulation system was carried out by analyzing heart rate variability, blood pressure was used to calculate hemodynamic parameters. These characteristics were analyzed in 6 male subjects (mean age 38\u0026thinsp;\u0026plusmn;\u0026thinsp;7 (SD) years) during the protocol of training rotations on the SAHC and during a passive orthostatic test with foot support (tilt test). 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