Diaphragmatic Pacing after Cervical Spinal Cord Injury due to Gunshot Wound: A 14- year Institutional Experience

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Labak, Eric Z. Herring, Elliot Crooks, Stanley F. Bazarek, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7059815/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 23 Sep, 2025 Read the published version in Acta Neurochirurgica → Version 1 posted 7 You are reading this latest preprint version Abstract Purpose High cervical spinal cord injury (SCI) due to gunshot wound (GSW) represents an extremely devastating injury class not only due to quadriplegia, but also the high incidence of chronic mechanical ventilation (MV) due to injury to the spinal nerves that innervate the diaphragm. Diaphragmatic pacemaker (DP) implantation is a potential option to liberate individuals from chronic MV by assisting with diaphragm contraction and therefore improving respiratory function. Methods We conducted a retrospective chart review at our institution to identify patients with high cervical SCI due to GSW who underwent DP implantation and had 6 months or more of clinical follow-up. Results Fourteen patients were included for chart review. Twelve patients were male; 9 were African American. Twelve had complete (ASIA A) SCI, of whom 7 had an injury at or above C3. Six of 12 (50%) patients whose MV status was documented achieved 4h and 24h per day of MV independence. All patients in whom detailed respiratory function data could be attained showed percentage tidal volumes over baseline requirement (PTVOB) greater than 100% (median:151.9%). Conclusion Consistent with previously published data, DP implantation for SCI due to GSW seems to have benefit with regard to MV independence and other respiratory metrics. This held true regardless of injury level or whether the DP was implanted during index hospitalization or in a delayed fashion. DP implantation is a viable option to consider in patients with high cervical SCI after GSW in both the acute and chronic setting to grant patients a potential for MV liberation. spinal cord injury quadriplegia diaphragmatic pacemaker mechanical ventilation Introduction Gunshot wounds (GSW) account for 10–15% of all traumatic spinal cord injury (SCI) in the United States ( 1 ). An analysis of the National Trauma Data Bank estimated that 2,187 cervical SCI between the years of 2015 and 2019 are due to GSW ( 2 ). In the case of upper cervical SCI, chronic respiratory failure is a devastating complication due to dysfunction of the upper cervical nerve roots–C3, C4, and C5–which innervate the diaphragm via the phrenic nerve. This can leave patients reliant on mechanical ventilation (MV), which has major implications related to personal healthcare costs, quality of life, risk of frequent respiratory infections, and overall a significantly reduced life expectancy ( 3 , 4 ). If the phrenic nerve and associated motor neurons remain intact after injury, an adjunctive therapy that can be utilized to lessen reliance on MV is the placement of a diaphragmatic pacer (DP) ( 5 ). This surgical procedure involves placement of electrodes along the diaphragm that are attached to a pulse generator, which has been described in previous work ( 6 ). While much of the literature on DP has been focused on SCI and critical illness polyneuropathy, DP has been applied to a number of different conditions including central hypoventilation syndrome and amyotrophic lateral sclerosis ( 6 , 7 , 8 ). Here, we report on our 14-year experience with the implantation of DP in SCI patients due to GSW, including patient characteristics and outcomes, and provide a review of the current literature. Methods Study Design A retrospective review of all adult patients who received an implanted DP after SCI due to GSW between the years of 2008 and May 2024 at our institution was performed. Patients with less than 6 months of clinical follow-up were excluded. Data Collection The variables collected for each patient included demographic data (age, sex, race, ethnicity), clinical presentation (level of SCI, American Spinal Injury Association Injury Scale (AIS) score, whether or not surgical intervention was required to stabilize the spinal column after their GSW), treatment modality information (timing of DP placement after SCI) and clinical outcomes (length of stay (LOS) after placement, ability to breathe without MV for >/=4h and </=24h, percentage of tidal volume over baseline requirement (PTVOB) at last follow-up, and complications). Data was managed in a protected Microsoft Excel spreadsheet. Basal tidal volume requirement & PTVOB To calculate basal tidal volume (V t ) requirement, each patient’s ideal body weight (IBW) was calculated. For men, the equation used was 50 + (0.91 × [height (cm) − 152.4]), and for women, it was 45.5 + (0.91 × [height (cm) − 152.4]). The basal V t was assumed to be 7ml/kg IBW for men, and 6ml/kg IBW for women. The PTVOB was then calculated as actual V t prior to discharge divided by the calculated V t based upon IBW. Statistical Analysis Data reporting and tabulation was performed with Excel (Microsoft Corp.). Results Baseline Characteristics A total of 14 patients were included in our study. The mean age for this cohort was 28.4 years, and 85.7% of these patients were male. Additionally, a majority were black/African American (64.3%). Of the group, 85.7% of patients suffered complete spinal cord injuries at the level of their gunshot wound (AIS A). Only one patient in whom DP was placed had a documented incomplete SCI from their GSW (AIS B). All injuries sustained were at the C5 spinal level or above. Additional demographic and clinical information is summarized in Table 1 . Table 1 Demographic, injury details and respiratory status pre-DP. Variable (n = 14) Frequency Percentage Gender Male 12 85.7% Female 2 14.3% Age (years) 28.4 (22.5) Race Black/African American 9 64.3% White/Caucasian 5 35.7% AIS Classification A 12 85.7% B 1 7.1% undocumented 1 7.1% Spinal injury level C2 4 28.6% C3 3 21.4% C4 4 28.6% C5 2 14.3% undocumented 1 7.1% MV-dependent prior to DP placement Yes 14 100% No 0 0% Deceased at time of chart review Yes 4 28.6% No 10 71.4% Respiratory Outcomes after DP Implantation Of the 12 patients whose DP utilization and/or MV-dependence status was recorded, 6 patients successfully reached at least 4 hours per day of continuous pacer use. The same 6 patients also were able to be paced for 24 hours. Of the 6 patients whose V t at last follow-up visit were documented, all of them had PTVOB well above 100% (median: 151.9%; IQR: 137.1–169.6%) (Table 2 ). Table 2 Respiratory status post-DP. Frequency Percentage Patients with MV dependence documented 12 85.7% Patients with actual Vt documented 6 42.9 ≥ 4 h/day ventilator independence at last follow-up 6 50.0% 24 h/day ventilator independence at last follow-up 6 50.0% Median IQR Q1 Q3 PTVOB (%) 151.9% 32.5% 137.1% 169.6% Impact of Level of Injury Of the 14 patients included in this study, 7 patients (50%) had injuries at or above C3, 6 patients (42.86%) had injuries at levels C4 or below, and one patient had an undocumented level of injury. Median LOS was shorter in patients with injuries at C3 or above (2 days; IQR 1–3 days) than in patients with injuries C4 and below (10 days; IQR 8.25–12.25 days). Of the patients with documented injury levels and MV independence status, 3 (50%) patients with an injury at or above C3, and 3 (50%) of the 4 patients with an injury at C4 or below reached ≥ 4 hours/day of continuous pacing. PTVOB between these same groups was similar comparing patients with injuries at or above C3 ( n = 2; median 153.8%; IQR 145.3–162.4%) or at levels C4 or below ( n = 4; median 151.9%; IQR 137.5–169.3%). Additional level-based respiratory data is summarized in Table 3 . Table 3 Clinical and respiratory status post-DP, by level of injury. Injury level Frequency Percentage C3 and above 7 50.0% C4 and below 6 42.9% Undocumented 1 7.1% Length of stay (days post-DP) Median IQR Q1 Q3 C3 and above 2 2 1 3 C4 and below 10 4.25 8.25 12.25 Undocumented 15 ≥ 4 h/day ventilator independence at last follow-up 1 Frequency Percentage C3 and above ( 6 ) 3 50.0% C4 and below ( 6 ) 3 50.0% 24 h/day ventilator independence at last follow-up 1 Frequency Percentage C3 and above ( 6 ) 3 50.0% C4 and below ( 6 ) 3 50.0% Patients with actual Vt documented Frequency Total 6 C3 and above 2 C4 and below 4 PTVOB (%) Median IQR Q1 Q3 C3 and above 153.84% 17.17% 145.26% 162.43% C4 and below 151.85% 31.82% 137.51% 169.32% 1 Eight ( 8 ) patients had undocumented injury levels and/or undocumented ventilation independence status and were therefore excluded. Timing of DP Implantation Six of the patients in our cohort had their DP implanted at the same hospitalization as their GSW; another 8 patients had their DP placed in a delayed fashion at a median 5 months post-GSW. Those who had their DP placed during index hospitalization had a median LOS of 12d post-implantation, whereas those who were brought back had a median LOS of 2.5d post-implantation. Two (33%) of the patients who had their DP placed in the same hospitalization had ≥ 24 hours/day MV independence at last follow-up whereas 4 (67%) of the patients who had their DP placed in a later hospitalization from their initial injury had ≥ 24 hours/day MV independence at last follow-up. The 5 patients who had DP implantation during index GSW hospitalization had a median PTVOB of 165.35% (IQR 138.34-171.01), while the lone patient who had their DP implanted at a later hospitalization had a PTVOB of 136.67%. (Table 4 ). Table 4 Clinical and respiratory status post-DP, by time to DP placement. Timing to DP placement Frequency Percentage During index hospitalization 6 42.86% Post-injury 8 57.14% Timing to DP placement Median IQR Q1 Q3 During index hospitalization (days) 8 2.75 7 9.75 Post-injury (months) 5 9 2.5 11.5 LOS (days post-DP) Median IQR Q1 Q3 All patients 5.5 11.25 1.25 12.5 During index hospitalization 12 5 8.75 13.75 Post-injury 2.5 3.5 1 4.5 ≥ 4 h/day ventilator independence at last follow-up 1 Frequency Percentage During index hospitalization ( 6 ) 2 33.3% Post-injury ( 6 ) 4 66.6% 24 h/day ventilator independence at last follow-up 1 Frequency Percentage During index hospitalization ( 6 ) 2 33.3% Post-injury ( 6 ) 4 66.6% Patients with actual Vt documented Frequency Total 6 During index hospitalization 5 Post-injury 1 PTVOB (%) Median IQR Q1 Q3 During index hospitalization ( 5 ) 165.35% 32.67% 138.34% 171.01% Post-injury ( 1 ) 136.67% - - - 1 Two ( 2 ) patients had undocumented injury levels and/or undocumented ventilation independence status and were therefore excluded. Discussion Based on recent estimates, GSWs are the third leading cause of SCI in the United States, and are the second leading cause in patients 16 to 30 years old ( SCIMS 2022 Annual Report , National Spinal Cord Injury Statistical Center). Of these, approximately one-third are located in the cervical spine ( 9 ). GSWs present a unique clinical problem in the context of neurologic dysfunction as they often result in injuries to multiple systems based on the path of the projectile. Additionally, the projectile is surrounded by a variable zone of blast injury which can lead to a heterogenous injury pattern ( 10 ). Due to these factors, GSW resulting in SCI represents a heterogeneous group of patients with a combination of central and peripheral nervous system dysfunction. Because respiratory function localizes to the cervical spinal roots C3, C4, and C5, from which the phrenic nerve arises, about 75% of high cervical GSW lead to chronic MV-dependence ( 11 ). MV carries with it known long-term sequelae, including reduced quality of life, increased cost of healthcare, and a lifelong risk of ventilator-associated events including pneumonia and other infections of the upper and lower airway, barotrauma, and premature death ( 12 , 6 ). Therefore, any benefit that can be gained from liberalizing SCI patients from MV may have a significant impact on modifying the trajectory of illness in SCI both in the short and long term. The largest study to date assessing DP for SCI of any etiology is a retrospective study by Onders et al. in which 92 patients’ outcomes were reviewed ( 6 ). A primary endpoint to assess the effectiveness of DP implantation post-GSW is the ability to breathe without the assistance of MV for at least 4 continuous hours per day. The authors found that patients achieving 4 continuous hours without the assistance of MV predicted MV-independence for 24 hours per day with high specificity, which is the impetus for this time point. In the most recent prospective study on surgical management to achieve MV independence conducted by Kaufman et al. , the group looked at DP implantation alone and with either phrenic nerve reconstruction or diaphragm muscle replacement–this group found that 80% of patients achieved partial or complete weaning from MV, with 40% achieving complete MV independence ( 13 ). All 6 patients in our retrospective study who achieved 4 hours per day of continuous DP use were also able to achieve 24 hours per day of continuous DP use, thus liberating them from MV. Additionally in our study, the subgroups were roughly balanced with regard to having DP implantation completed during the same hospitalization as their GSW-induced SCI versus having a delayed implantation of DP following discharge from the hospital to a rehabilitation center. Unfortunately, a subgroup analysis is not possible given the small sizes of our groups, however our data does suggest that DP can successfully liberate patients from MV if placed in an immediate or delayed fashion. If the institution can offer this treatment, it seems to be a low-risk option to implant the device early and attempt to liberate the patient from MV early. However, even if the index injury is cared for at an institution that does not offer DP implantation, patients can be referred in a delayed fashion to receive DP implantation as an attempt to reduce chronic MV dependence. With regard to the level of injury, prior work has demonstrated that the level of injury in all types of cervical SCI is a factor correlated with independence from MV, specifically differentiating between the C3 and C4 levels ( 14 ). Our study did not find a difference between these two populations, which is likely more attributable to our study being underpowered. However, there may be a different injury pattern in GSW to the spinal cord rather than traumatic injuries where the zone of injury far exceeds the level of injury. One important takeaway from our study regardless of this, is that even in cases where the anterior horns of the phrenic nerve are presumed to be disrupted secondary to the GSW (all cases in our study had GSW affecting C3-5), successful DP and MV freedom can still be accomplished in these patients. Importantly, patients with high cervical SCI are frequently considered for early tracheostomy to reduce outcomes related to MV in patient highly likely to be MV dependent ( 15 ). Similarly, DP after high cervical SCI should also be a consideration as the majority of patients with high SCI are ultimately likely to need some form of MV ( 16 ). This study is bound by the limitations of a small, retrospective cohort and lack of a comparison cohort with regard to drawing larger conclusions about the efficacy and safety of DP implantation. Additionally, our study saw substantial missingness of data likely related to difficulty in following up on patients who came to our hospital system solely for their DP placement (and then returned home afterward). However, the results overall support that DP is a reasonable option to consider for GSW-induced high cervical SCI patients to attempt to achieve MV independence, whether considered during index hospitalization in an acute fashion or in a delayed fashion on follow-up. Further work is needed to make providers caring for these patients aware of the possible options available that may lead to the successful liberation of MV. Conclusion GSW resulting in high cervical SCI are likely to result in significant respiratory dysfunction and ultimately require MV dependence. Our study examined the use of DP in high cervical spinal cord injuries secondary to GSW at our institution. Though there are significant limitations related to a small patient cohort, overall our results support that DP is a reasonable option to consider for GSW-induced high cervical SCI patients to attempt to achieve MV independence, whether considered during index hospitalization in an acute fashion or in a delayed fashion on follow-up. Declarations Human Ethics and Consent to Participate declarations: not applicable. This was a retrospective study without need for human consent to participate. Ethical Approval and Consent to Participate All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethical approval for this study was obtained fromUniversity Hospitals Institutional Review Board. Informed consent was not obtained from individual subjects included in the study as this was a purely retrospective chart review. Consent for Publication Not applicable. Conflict of Interest The authors declare that they have no conflicts of interest relevant to this study. Author Contribution CML, EZH, and EC wrote the manuscript and prepared pertinent figures. SFB, GAS, RO oversaw project direction and provided feedback on manuscript. All authors reviewed the manuscript. References National Spinal Cord Injury Statistical Center (2013) Spinal cord injury facts and figures at a glance. 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Surgery 164(4):705–711. 10.1016/j.surg.2018.06.050 Hazenberg A, Hofker SS, van der Aa JG, Nieuwenhuis JA, Kerstjens HA, Wijkstra PJ (2013) Diafragmapacemaker: alternatief voor chronische beademing [Diaphragm pacemaker: alternative for chronic ventilatory support]. Ned Tijdschr Geneeskd 157(5):A5572 Onders RP, Elmo M, Kaplan C, Schilz R, Katirji B, Tinkoff G (2018) Long-term experience with diaphragm pacing for traumatic spinal cord injury: Early implantation should be considered. Surgery 164(4):705–711. 10.1016/j.surg.2018.06.050 Slattery SM, Perez IA, Ceccherini I et al (2023) Transitional care and clinical management of adolescents, young adults, and suspected new adult patients with congenital central hypoventilation syndrome. Clin Auton Res 33(3):231–249. 10.1007/s10286-022-00908-8 Amirjani N, Kiernan MC, McKenzie DK, Butler JE, Gandevia SC (2012) Is there a case for diaphragm pacing for amyotrophic lateral sclerosis patients? Amyotroph Lateral Scler 13(6):521–527. 10.3109/17482968.2012.673169 Sidhu GS, Ghag A, Prokuski V, Vaccaro AR, Radcliff KE (2013) Civilian gunshot injuries of the spinal cord: a systematic review of the current literature. Clin Orthop Relat Res 471(12):3945–3955. 10.1007/s11999-013-2901-2 Stefanopoulos PK, Filippakis K, Soupiou OT, Pazarakiotis VC (2014) Wound ballistics of firearm-related injuries–part 1: missile characteristics and mechanisms of soft tissue wounding. Int J Oral Maxillofac Surg 43(12):1445–1458. 10.1016/j.ijom.2014.07.013 Call MS, Kutcher ME, Izenberg RA, Singh T, Cohen MJ (2011) Spinal cord injury: outcomes of ventilatory weaning and extubation. J Trauma 71(6):1673–1679. 10.1097/TA.0b013e31821e87c2 Krause JS, Cao Y, DeVivo MJ, DiPiro ND (2016) Risk and Protective Factors for Cause-Specific Mortality After Spinal Cord Injury. Arch Phys Med Rehabil 97(10):1669–1678. 10.1016/j.apmr.2016.07.001 Kaufman MR, Bauer T, Campbell S, Rossi K, Elkwood A, Jarrahy R (2022) Prospective analysis of a surgical algorithm to achieve ventilator weaning in cervical tetraplegia. J Spinal Cord Med 45(4):531–535. 10.1080/10790268.2020.1829417 Korupolu R, Uhlig-Reche H, Achilike EC, Reeh C, Pedroza C, Stampas A (2022) Factors Associated With Ventilator Weaning Success and Failure in People With Spinal Cord Injury in an Acute Inpatient Rehabilitation Setting: A Retrospective Study. Top Spinal Cord Inj Rehabil 28(2):129–138. 10.46292/sci21-00062 Sun L, Feng H, Mei J et al (2023) One-stage tracheostomy during surgery reduced early pulmonary infection and mechanical ventilation length in complete CSCI patients. Front Surg 9:1082428 Published 2023 Mar 17. 10.3389/fsurg.2022.1082428 Call MS, Kutcher ME, Izenberg RA, Singh T, Cohen MJ (2011) Spinal cord injury: outcomes of ventilatory weaning and extubation. J Trauma 71(6):1673–1679. 10.1097/TA.0b013e31821e87c2 Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 23 Sep, 2025 Read the published version in Acta Neurochirurgica → Version 1 posted Editorial decision: Accepted 08 Sep, 2025 Reviews received at journal 05 Sep, 2025 Reviewers agreed at journal 28 Aug, 2025 Reviewers invited by journal 28 Aug, 2025 Editor assigned by journal 26 Aug, 2025 Submission checks completed at journal 26 Aug, 2025 First submitted to journal 06 Jul, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7059815","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":509253834,"identity":"05145f00-43e4-4446-b300-2238a72a3e35","order_by":0,"name":"Collin M. 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Herring","email":"","orcid":"","institution":"University Hospitals Cleveland Medical Center","correspondingAuthor":false,"prefix":"","firstName":"Eric","middleName":"Z.","lastName":"Herring","suffix":""},{"id":509253836,"identity":"a1dbba74-1777-4bb0-a359-1d6ca0e619ae","order_by":2,"name":"Elliot Crooks","email":"","orcid":"","institution":"University Hospitals Cleveland Medical Center","correspondingAuthor":false,"prefix":"","firstName":"Elliot","middleName":"","lastName":"Crooks","suffix":""},{"id":509253837,"identity":"24cfa23e-e908-4344-9d1e-21695da1a7ab","order_by":3,"name":"Stanley F. Bazarek","email":"","orcid":"","institution":"University Hospitals Cleveland Medical Center","correspondingAuthor":false,"prefix":"","firstName":"Stanley","middleName":"F.","lastName":"Bazarek","suffix":""},{"id":509253838,"identity":"40896773-78d6-47fc-ae41-43487d3d6496","order_by":4,"name":"Gabriel A. Smith","email":"","orcid":"","institution":"University Hospitals Cleveland Medical Center","correspondingAuthor":false,"prefix":"","firstName":"Gabriel","middleName":"A.","lastName":"Smith","suffix":""},{"id":509253839,"identity":"df7f6a3c-cd80-45cc-883e-9fc892fc5093","order_by":5,"name":"Raymond Onders","email":"","orcid":"","institution":"University Hospitals Cleveland Medical Center","correspondingAuthor":false,"prefix":"","firstName":"Raymond","middleName":"","lastName":"Onders","suffix":""}],"badges":[],"createdAt":"2025-07-06 21:08:10","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7059815/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7059815/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s00701-025-06678-2","type":"published","date":"2025-09-23T15:57:52+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":92430634,"identity":"101316ee-2711-4930-9da7-8505262e0656","added_by":"auto","created_at":"2025-09-29 16:07:03","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":697759,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-7059815/v1/a5fd600c-5bbc-47b1-8073-2cea5c99aa3f.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Diaphragmatic Pacing after Cervical Spinal Cord Injury due to Gunshot Wound: A 14- year Institutional Experience","fulltext":[{"header":"Introduction","content":"\u003cp\u003eGunshot wounds (GSW) account for 10\u0026ndash;15% of all traumatic spinal cord injury (SCI) in the United States (\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e). An analysis of the National Trauma Data Bank estimated that 2,187 cervical SCI between the years of 2015 and 2019 are due to GSW (\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e). In the case of upper cervical SCI, chronic respiratory failure is a devastating complication due to dysfunction of the upper cervical nerve roots\u0026ndash;C3, C4, and C5\u0026ndash;which innervate the diaphragm via the phrenic nerve. This can leave patients reliant on mechanical ventilation (MV), which has major implications related to personal healthcare costs, quality of life, risk of frequent respiratory infections, and overall a significantly reduced life expectancy (\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eIf the phrenic nerve and associated motor neurons remain intact after injury, an adjunctive therapy that can be utilized to lessen reliance on MV is the placement of a diaphragmatic pacer (DP) (\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e). This surgical procedure involves placement of electrodes along the diaphragm that are attached to a pulse generator, which has been described in previous work (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e). While much of the literature on DP has been focused on SCI and critical illness polyneuropathy, DP has been applied to a number of different conditions including central hypoventilation syndrome and amyotrophic lateral sclerosis (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e, \u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e). Here, we report on our 14-year experience with the implantation of DP in SCI patients due to GSW, including patient characteristics and outcomes, and provide a review of the current literature.\u003c/p\u003e"},{"header":"Methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e\u003ch2\u003eStudy Design\u003c/h2\u003e\u003cp\u003eA retrospective review of all adult patients who received an implanted DP after SCI due to GSW between the years of 2008 and May 2024 at our institution was performed. Patients with less than 6 months of clinical follow-up were excluded.\u003c/p\u003e\u003c/div\u003e\n\u003ch3\u003eData Collection\u003c/h3\u003e\n\u003cp\u003eThe variables collected for each patient included demographic data (age, sex, race, ethnicity), clinical presentation (level of SCI, American Spinal Injury Association Injury Scale (AIS) score, whether or not surgical intervention was required to stabilize the spinal column after their GSW), treatment modality information (timing of DP placement after SCI) and clinical outcomes (length of stay (LOS) after placement, ability to breathe without MV for \u0026gt;/=4h and \u0026lt;/=24h, percentage of tidal volume over baseline requirement (PTVOB) at last follow-up, and complications). Data was managed in a protected Microsoft Excel spreadsheet.\u003c/p\u003e\n\u003ch3\u003eBasal tidal volume requirement \u0026 PTVOB\u003c/h3\u003e\n\u003cp\u003eTo calculate basal tidal volume (V\u003csub\u003et\u003c/sub\u003e) requirement, each patient\u0026rsquo;s ideal body weight (IBW) was calculated. For men, the equation used was 50 + (0.91 \u0026times; [height (cm)\u0026thinsp;\u0026minus;\u0026thinsp;152.4]), and for women, it was 45.5 + (0.91 \u0026times; [height (cm)\u0026thinsp;\u0026minus;\u0026thinsp;152.4]). The basal V\u003csub\u003et\u003c/sub\u003e was assumed to be 7ml/kg IBW for men, and 6ml/kg IBW for women. The PTVOB was then calculated as actual V\u003csub\u003et\u003c/sub\u003e prior to discharge divided by the calculated V\u003csub\u003et\u003c/sub\u003e based upon IBW.\u003c/p\u003e\u003cdiv id=\"Sec6\" class=\"Section2\"\u003e\u003ch2\u003eStatistical Analysis\u003c/h2\u003e\u003cp\u003eData reporting and tabulation was performed with Excel (Microsoft Corp.).\u003c/p\u003e\u003c/div\u003e"},{"header":"Results","content":"\u003cdiv id=\"Sec8\" class=\"Section2\"\u003e\u003ch2\u003eBaseline Characteristics\u003c/h2\u003e\u003cp\u003eA total of 14 patients were included in our study. The mean age for this cohort was 28.4 years, and 85.7% of these patients were male. Additionally, a majority were black/African American (64.3%). Of the group, 85.7% of patients suffered complete spinal cord injuries at the level of their gunshot wound (AIS A). Only one patient in whom DP was placed had a documented incomplete SCI from their GSW (AIS B). All injuries sustained were at the C5 spinal level or above. Additional demographic and clinical information is summarized in Table\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e.\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab1\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eDemographic, injury details and respiratory status pre-DP.\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"4\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"char\" char=\".\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003eVariable \u003cem\u003e(n\u0026thinsp;=\u0026thinsp;14)\u003c/em\u003e\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c3\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cp\u003ePercentage\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eGender\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eMale\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e12\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e85.7%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eFemale\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e2\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e14.3%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eAge (years)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e28.4 (22.5)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eRace\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eBlack/African American\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e9\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e64.3%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eWhite/Caucasian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e5\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e35.7%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003eAIS Classification\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eA\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e12\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e85.7%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eB\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e7.1%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eundocumented\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e7.1%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003eSpinal injury level\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eC2\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e4\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e28.6%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eC3\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e3\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e21.4%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eC4\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e4\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e28.6%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eC5\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e2\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e14.3%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eundocumented\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e7.1%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003eMV-dependent prior to DP placement\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eYes\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e14\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e100%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eNo\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e0\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e0%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003eDeceased at time of chart review\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eYes\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e4\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e28.6%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eNo\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"char\" char=\".\" colname=\"c3\"\u003e\u003cp\u003e10\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e71.4%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\u003c/div\u003e\n\u003ch3\u003eRespiratory Outcomes after DP Implantation\u003c/h3\u003e\n\u003cp\u003eOf the 12 patients whose DP utilization and/or MV-dependence status was recorded, 6 patients successfully reached at least 4 hours per day of continuous pacer use. The same 6 patients also were able to be paced for 24 hours. Of the 6 patients whose V\u003csub\u003et\u003c/sub\u003e at last follow-up visit were documented, all of them had PTVOB well above 100% (median: 151.9%; IQR: 137.1\u0026ndash;169.6%) (Table\u0026nbsp;\u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e).\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eRespiratory status post-DP.\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u0026nbsp;\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e\u003cp\u003ePercentage\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003ePatients with MV dependence documented\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e12\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e85.7%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003ePatients with actual Vt documented\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e6\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e42.9\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003e\u0026ge; 4 h/day ventilator independence at last follow-up\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e6\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e50.0%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003e24 h/day ventilator independence at last follow-up\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e6\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e50.0%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eMedian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003eIQR\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eQ1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003eQ3\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePTVOB (%)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e151.9%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e32.5%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e137.1%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e169.6%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\n\u003ch3\u003eImpact of Level of Injury\u003c/h3\u003e\n\u003cp\u003eOf the 14 patients included in this study, 7 patients (50%) had injuries at or above C3, 6 patients (42.86%) had injuries at levels C4 or below, and one patient had an undocumented level of injury. Median LOS was shorter in patients with injuries at C3 or above (2 days; IQR 1\u0026ndash;3 days) than in patients with injuries C4 and below (10 days; IQR 8.25\u0026ndash;12.25 days). Of the patients with documented injury levels and MV independence status, 3 (50%) patients with an injury at or above C3, and 3 (50%) of the 4 patients with an injury at C4 or below reached\u0026thinsp;\u0026ge;\u0026thinsp;4 hours/day of continuous pacing. PTVOB between these same groups was similar comparing patients with injuries at or above C3 (\u003cem\u003en\u003c/em\u003e\u0026thinsp;=\u0026thinsp;2; median 153.8%; IQR 145.3\u0026ndash;162.4%) or at levels C4 or below (\u003cem\u003en\u003c/em\u003e\u0026thinsp;=\u0026thinsp;4; median 151.9%; IQR 137.5\u0026ndash;169.3%). Additional level-based respiratory data is summarized in Table\u0026nbsp;\u003cspan refid=\"Tab3\" class=\"InternalRef\"\u003e3\u003c/span\u003e.\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab3\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 3\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eClinical and respiratory status post-DP, by level of injury.\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003eInjury level\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e\u003cp\u003ePercentage\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC3 and above\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e7\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e50.0%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC4 and below\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e6\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e42.9%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eUndocumented\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e7.1%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eLength of stay (days post-DP)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eMedian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003eIQR\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eQ1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003eQ3\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC3 and above\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e2\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e2\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e3\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC4 and below\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e10\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e4.25\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e8.25\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e12.25\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eUndocumented\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e15\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003e\u0026ge;\u0026thinsp;4 h/day ventilator independence at last follow-up\u003csup\u003e1\u003c/sup\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003ePercentage\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC3 and above (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e3\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e50.0%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC4 and below (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e3\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e50.0%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003e24 h/day ventilator independence at last follow-up\u003csup\u003e1\u003c/sup\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003ePercentage\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC3 and above (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e3\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e50.0%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC4 and below (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e3\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e50.0%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003ePatients with actual Vt documented\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eTotal\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e6\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC3 and above\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e2\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC4 and below\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e4\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePTVOB (%)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eMedian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003eIQR\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eQ1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003eQ3\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC3 and above\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e153.84%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e17.17%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e145.26%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e162.43%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eC4 and below\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e151.85%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e31.82%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e137.51%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e169.32%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"5\"\u003e\u003csup\u003e1\u003c/sup\u003e Eight (\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e) patients had undocumented injury levels and/or undocumented ventilation independence status and were therefore excluded.\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\u003cdiv id=\"Sec11\" class=\"Section2\"\u003e\u003ch2\u003eTiming of DP Implantation\u003c/h2\u003e\u003cp\u003eSix of the patients in our cohort had their DP implanted at the same hospitalization as their GSW; another 8 patients had their DP placed in a delayed fashion at a median 5 months post-GSW. Those who had their DP placed during index hospitalization had a median LOS of 12d post-implantation, whereas those who were brought back had a median LOS of 2.5d post-implantation. Two (33%) of the patients who had their DP placed in the same hospitalization had\u0026thinsp;\u0026ge;\u0026thinsp;24 hours/day MV independence at last follow-up whereas 4 (67%) of the patients who had their DP placed in a later hospitalization from their initial injury had\u0026thinsp;\u0026ge;\u0026thinsp;24 hours/day MV independence at last follow-up. The 5 patients who had DP implantation during index GSW hospitalization had a median PTVOB of 165.35% (IQR 138.34-171.01), while the lone patient who had their DP implanted at a later hospitalization had a PTVOB of 136.67%. (Table\u0026nbsp;\u003cspan refid=\"Tab4\" class=\"InternalRef\"\u003e4\u003c/span\u003e).\u003c/p\u003e\u003cp\u003e\u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab4\" border=\"1\"\u003e\u003ccaption language=\"En\"\u003e\u003cdiv class=\"CaptionNumber\"\u003eTable 4\u003c/div\u003e\u003cdiv class=\"CaptionContent\"\u003e\u003cp\u003eClinical and respiratory status post-DP, by time to DP placement.\u003c/p\u003e\u003c/div\u003e\u003c/caption\u003e\u003ccolgroup cols=\"5\"\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e\u003cdiv align=\"left\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e\u003cthead\u003e\u003ctr\u003e\u003cth align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003eTiming to DP placement\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c4\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/th\u003e\u003cth align=\"left\" colname=\"c5\"\u003e\u003cp\u003ePercentage\u003c/p\u003e\u003c/th\u003e\u003c/tr\u003e\u003c/thead\u003e\u003ctbody\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003eDuring index hospitalization\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e6\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e42.86%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003ePost-injury\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e8\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e57.14%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eTiming to DP placement\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eMedian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003eIQR\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eQ1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003eQ3\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eDuring index hospitalization (days)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e8\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e2.75\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e7\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e9.75\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePost-injury (months)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e5\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e9\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e2.5\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e11.5\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eLOS (days post-DP)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eMedian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003eIQR\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eQ1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003eQ3\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eAll patients\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e5.5\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e11.25\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e1.25\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e12.5\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eDuring index hospitalization\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e12\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e5\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e8.75\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e13.75\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePost-injury\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e2.5\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e3.5\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e4.5\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003e\u0026ge;\u0026thinsp;4 h/day ventilator independence at last follow-up\u003csup\u003e1\u003c/sup\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003ePercentage\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003eDuring index hospitalization (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e2\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e33.3%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePost-injury (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e4\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e66.6%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003e24 h/day ventilator independence at last follow-up\u003csup\u003e1\u003c/sup\u003e\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003ePercentage\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003eDuring index hospitalization (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e2\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e33.3%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePost-injury (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e4\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e66.6%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"3\" nameend=\"c3\" namest=\"c1\"\u003e\u003cp\u003ePatients with actual Vt documented\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eFrequency\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eTotal\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e6\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colspan=\"2\" nameend=\"c2\" namest=\"c1\"\u003e\u003cp\u003eDuring index hospitalization\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e5\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePost-injury\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u0026nbsp;\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u0026nbsp;\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePTVOB (%)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003eMedian\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003eIQR\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003eQ1\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003eQ3\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003eDuring index hospitalization (\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e165.35%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e32.67%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e138.34%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e171.01%\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003ctr\u003e\u003ctd align=\"left\" colname=\"c1\"\u003e\u003cp\u003ePost-injury (\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e)\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c2\"\u003e\u003cp\u003e136.67%\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c3\"\u003e\u003cp\u003e-\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c4\"\u003e\u003cp\u003e-\u003c/p\u003e\u003c/td\u003e\u003ctd align=\"left\" colname=\"c5\"\u003e\u003cp\u003e-\u003c/p\u003e\u003c/td\u003e\u003c/tr\u003e\u003c/tbody\u003e\u003c/colgroup\u003e\u003ctfoot\u003e\u003ctr\u003e\u003ctd colspan=\"5\"\u003e\u003csup\u003e1\u003c/sup\u003e Two (\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e) patients had undocumented injury levels and/or undocumented ventilation independence status and were therefore excluded.\u003c/td\u003e\u003c/tr\u003e\u003c/tfoot\u003e\u003c/table\u003e\u003c/div\u003e\u003c/p\u003e\u003c/div\u003e"},{"header":"Discussion","content":"\u003cp\u003eBased on recent estimates, GSWs are the third leading cause of SCI in the United States, and are the second leading cause in patients 16 to 30 years old (\u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003eSCIMS 2022 Annual Report\u003c/span\u003e, National Spinal Cord Injury Statistical Center). Of these, approximately one-third are located in the cervical spine (\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e). GSWs present a unique clinical problem in the context of neurologic dysfunction as they often result in injuries to multiple systems based on the path of the projectile. Additionally, the projectile is surrounded by a variable zone of blast injury which can lead to a heterogenous injury pattern (\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e). Due to these factors, GSW resulting in SCI represents a heterogeneous group of patients with a combination of central and peripheral nervous system dysfunction.\u003c/p\u003e\u003cp\u003eBecause respiratory function localizes to the cervical spinal roots C3, C4, and C5, from which the phrenic nerve arises, about 75% of high cervical GSW lead to chronic MV-dependence (\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e). MV carries with it known long-term sequelae, including reduced quality of life, increased cost of healthcare, and a lifelong risk of ventilator-associated events including pneumonia and other infections of the upper and lower airway, barotrauma, and premature death (\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e). Therefore, any benefit that can be gained from liberalizing SCI patients from MV may have a significant impact on modifying the trajectory of illness in SCI both in the short and long term.\u003c/p\u003e\u003cp\u003eThe largest study to date assessing DP for SCI of any etiology is a retrospective study by Onders \u003cem\u003eet al.\u003c/em\u003e in which 92 patients\u0026rsquo; outcomes were reviewed (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e). A primary endpoint to assess the effectiveness of DP implantation post-GSW is the ability to breathe without the assistance of MV for at least 4 continuous hours per day. The authors found that patients achieving 4 continuous hours without the assistance of MV predicted MV-independence for 24 hours per day with high specificity, which is the impetus for this time point. In the most recent prospective study on surgical management to achieve MV independence conducted by Kaufman \u003cem\u003eet al.\u003c/em\u003e, the group looked at DP implantation alone and with either phrenic nerve reconstruction or diaphragm muscle replacement\u0026ndash;this group found that 80% of patients achieved partial or complete weaning from MV, with 40% achieving complete MV independence (\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e). All 6 patients in our retrospective study who achieved 4 hours per day of continuous DP use were also able to achieve 24 hours per day of continuous DP use, thus liberating them from MV.\u003c/p\u003e\u003cp\u003eAdditionally in our study, the subgroups were roughly balanced with regard to having DP implantation completed during the same hospitalization as their GSW-induced SCI versus having a delayed implantation of DP following discharge from the hospital to a rehabilitation center. Unfortunately, a subgroup analysis is not possible given the small sizes of our groups, however our data does suggest that DP can successfully liberate patients from MV if placed in an immediate or delayed fashion. If the institution can offer this treatment, it seems to be a low-risk option to implant the device early and attempt to liberate the patient from MV early. However, even if the index injury is cared for at an institution that does not offer DP implantation, patients can be referred in a delayed fashion to receive DP implantation as an attempt to reduce chronic MV dependence.\u003c/p\u003e\u003cp\u003eWith regard to the level of injury, prior work has demonstrated that the level of injury in all types of cervical SCI is a factor correlated with independence from MV, specifically differentiating between the C3 and C4 levels (\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e). Our study did not find a difference between these two populations, which is likely more attributable to our study being underpowered. However, there may be a different injury pattern in GSW to the spinal cord rather than traumatic injuries where the zone of injury far exceeds the level of injury. One important takeaway from our study regardless of this, is that even in cases where the anterior horns of the phrenic nerve are presumed to be disrupted secondary to the GSW (all cases in our study had GSW affecting C3-5), successful DP and MV freedom can still be accomplished in these patients. Importantly, patients with high cervical SCI are frequently considered for early tracheostomy to reduce outcomes related to MV in patient highly likely to be MV dependent (\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e). Similarly, DP after high cervical SCI should also be a consideration as the majority of patients with high SCI are ultimately likely to need some form of MV (\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eThis study is bound by the limitations of a small, retrospective cohort and lack of a comparison cohort with regard to drawing larger conclusions about the efficacy and safety of DP implantation. Additionally, our study saw substantial missingness of data likely related to difficulty in following up on patients who came to our hospital system solely for their DP placement (and then returned home afterward). However, the results overall support that DP is a reasonable option to consider for GSW-induced high cervical SCI patients to attempt to achieve MV independence, whether considered during index hospitalization in an acute fashion or in a delayed fashion on follow-up. Further work is needed to make providers caring for these patients aware of the possible options available that may lead to the successful liberation of MV.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eGSW resulting in high cervical SCI are likely to result in significant respiratory dysfunction and ultimately require MV dependence. Our study examined the use of DP in high cervical spinal cord injuries secondary to GSW at our institution. Though there are significant limitations related to a small patient cohort, overall our results support that DP is a reasonable option to consider for GSW-induced high cervical SCI patients to attempt to achieve MV independence, whether considered during index hospitalization in an acute fashion or in a delayed fashion on follow-up.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eHuman Ethics and Consent to Participate declarations: not applicable.\u003c/p\u003e\n\u003cp\u003eThis was a retrospective study without need for human consent to participate.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eEthical Approval and Consent to Participate\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethical approval for this study was obtained fromUniversity Hospitals Institutional Review Board. Informed consent was not obtained from individual subjects included in the study as this was a purely retrospective chart review.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eConsent for Publication\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eConflict of Interest\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no conflicts of interest relevant to this study.\u003c/p\u003e\u003ch2\u003eAuthor Contribution\u003c/h2\u003e\u003cp\u003eCML, EZH, and EC wrote the manuscript and prepared pertinent figures. SFB, GAS, RO oversaw project direction and provided feedback on manuscript. 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J Trauma 71(6):1673\u0026ndash;1679. \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003e10.1097/TA.0b013e31821e87c2\u003c/span\u003e\u003cspan address=\"10.1097/TA.0b013e31821e87c2\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"acta-neurochirurgica","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"anch","sideBox":"Learn more about [Acta Neurochirurgica](http://link.springer.com/journal/701)","snPcode":"701","submissionUrl":"https://submission.springernature.com/new-submission/701/3","title":"Acta Neurochirurgica","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"spinal cord injury, quadriplegia, diaphragmatic pacemaker, mechanical ventilation","lastPublishedDoi":"10.21203/rs.3.rs-7059815/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7059815/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003ePurpose\u003c/h2\u003e\u003cp\u003eHigh cervical spinal cord injury (SCI) due to gunshot wound (GSW) represents an extremely devastating injury class not only due to quadriplegia, but also the high incidence of chronic mechanical ventilation (MV) due to injury to the spinal nerves that innervate the diaphragm. Diaphragmatic pacemaker (DP) implantation is a potential option to liberate individuals from chronic MV by assisting with diaphragm contraction and therefore improving respiratory function.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e\u003cp\u003eWe conducted a retrospective chart review at our institution to identify patients with high cervical SCI due to GSW who underwent DP implantation and had 6 months or more of clinical follow-up.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eFourteen patients were included for chart review. Twelve patients were male; 9 were African American. Twelve had complete (ASIA A) SCI, of whom 7 had an injury at or above C3. Six of 12 (50%) patients whose MV status was documented achieved 4h and 24h per day of MV independence. All patients in whom detailed respiratory function data could be attained showed percentage tidal volumes over baseline requirement (PTVOB) greater than 100% (median:151.9%).\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e\u003cp\u003eConsistent with previously published data, DP implantation for SCI due to GSW seems to have benefit with regard to MV independence and other respiratory metrics. This held true regardless of injury level or whether the DP was implanted during index hospitalization or in a delayed fashion. DP implantation is a viable option to consider in patients with high cervical SCI after GSW in both the acute and chronic setting to grant patients a potential for MV liberation.\u003c/p\u003e","manuscriptTitle":"Diaphragmatic Pacing after Cervical Spinal Cord Injury due to Gunshot Wound: A 14- year Institutional Experience","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-09-04 14:40:10","doi":"10.21203/rs.3.rs-7059815/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Accepted","date":"2025-09-08T08:21:13+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2025-09-05T21:14:57+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"249035092445194466368011266812301230443","date":"2025-08-28T14:57:07+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-08-28T13:29:22+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-08-27T03:11:58+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-08-27T03:10:27+00:00","index":"","fulltext":""},{"type":"submitted","content":"Acta Neurochirurgica","date":"2025-07-06T20:58:10+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"acta-neurochirurgica","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"anch","sideBox":"Learn more about [Acta Neurochirurgica](http://link.springer.com/journal/701)","snPcode":"701","submissionUrl":"https://submission.springernature.com/new-submission/701/3","title":"Acta Neurochirurgica","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"84fcb28f-3524-4d88-a55d-9222b0f3c44f","owner":[],"postedDate":"September 4th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2025-09-29T16:03:46+00:00","versionOfRecord":{"articleIdentity":"rs-7059815","link":"https://doi.org/10.1007/s00701-025-06678-2","journal":{"identity":"acta-neurochirurgica","isVorOnly":false,"title":"Acta Neurochirurgica"},"publishedOn":"2025-09-23 15:57:52","publishedOnDateReadable":"September 23rd, 2025"},"versionCreatedAt":"2025-09-04 14:40:10","video":"","vorDoi":"10.1007/s00701-025-06678-2","vorDoiUrl":"https://doi.org/10.1007/s00701-025-06678-2","workflowStages":[]},"version":"v1","identity":"rs-7059815","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7059815","identity":"rs-7059815","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}