Genome sequence of Corynebacterium Amycolatum ICIS 99 Isolated From Human Vagina Reveals Safety and Beneficial Properties

Abstract Corynebacterium amycolatum ICIS 99 was isolated from vaginal smears of healthy women and showed promising results in antimicrobial screenings. Here, we report the draft genome sequence of this strain and analyze its main features to assess its safety and useful properties. The genome is 2,532,503 bp long and contains 2,186 CDSs with an average G+C content of 59.0%. Analyses of the ICIS 99 genome revealed the absence of true virulence genes. The genome contains genes involved in the synthesis of secondary metabolites and bacteriocins of the class sactipeptide. In the genome of ICIS 99, we identified a large number of genes responsible for adaptation and survival in the vaginal environment, including acid and oxidative stress resistance genes. The genomic information of ICIS 99 provides a basis for understanding the safety and useful properties of ICIS 99 and for considering it as a potential probiotic strain. However, further research is needed to test its probiotic efficacy in vivo. The whole genome shotgun project has been deposited at DDBJ/ENA/GenBank under the accession number JAIUSU000000000.