Integrated shimming enables independently parallel NMR detection

Two major technical challenges facing parallel nuclear magnetic resonance (NMR) spectroscopy, at the onset, include the need to achieve exceptional B0 homogeneity, and good inter-detector radiofrequency signal decoupling, and have remained technical obstacles that limit high throughput compound screening via NMR. In this contribution, we consider a compact detector system, consisting of two NMR ’unit cell’ resonators that implement parallel B0 shimming with parallel radiofrequency detection, as a prototype NMR environment, pointing the way towards achieving accelerated NMR analysis. The utility of our approach is established by achieving local field correction within the bore of a 1.05 T permanent magnet MRI. Our forerunner platform suppresses signal cross coupling down to −30 dB under a geometrical decoupled scheme, leading to a halving of the necessary inter-coil distance. In this permanent magnet enviroment, two decoupled parallel NMR detector sites simultaneously achieve improved spectral linewidth, from 270 Hz to 24 Hz.