Clinical study on moderate and severe endometriosis operation combined drug therapy

Objective To investigate the effect and severe adverse reactions of goserelin combined with mifepristone after operation for moderate and endometriosis laparoscopic conservative.Methods 68 cases with moderate to severe endometriosis diagnosed after laparoscopic conservative operation were randomly divided into the Gore Sherry Lin group and mifepristone group with 34 cases for 6 months of a course,regular follow-up.Clinical efficacy and adverse reaction for two groups were compared.Results The dysmenorrhea symptoms for two groups of patients have been alleviated,the efficiency rate was above 91％.The recurrence rate of the mifepristone group was higher than the goserelin group (14.71％ vs 2.94％,P ＜ 0.05).The cumulative pregnancy rate of mifepristone group was lower than the goserelin group (20.59％ vs 38.23 ％,P ＜ 0.05) discontinued for 1 years.The liver function damage of the goserelin group was significantly lower than the mifepristone group (2.94％ vs 23.53％,P ＜ 0.05).Conclusion It is more significance for using suppression of ovarian function after laparoscopic conservative operation for severe endometriosis.It can increase the pregnancy rate and decrease the recurrence rate. Key words: Endometriosis; Laparoscopy; Goserelin; Mifepristone