WITHDRAWN: Beyond Binding Affinity: The Kinetic-Compatibility Hypothesis for Nipah Virus Neutralization: Decoding the Affinity Paradox Across 1,194 Designed Miniproteins
This withdrawn manuscript investigated miniprotein binding kinetics for Nipah virus neutralization, but the data analyzed targeted the Attachment (G) glycoprotein, not the intended Fusion (F) protein.
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The manuscript proposed a kinetic-compatibility hypothesis to explain an “affinity paradox” in Nipah virus neutralization, using functional and sequence data from 1,194 designed miniproteins, and framing analysis in terms of mechanical transitions of the Nipah fusion (F) protein. The authors withdrew the work after identifying a fundamental error: the biological functional data they used were actually directed toward the Nipah attachment (G) glycoprotein rather than the F protein. Although the sequence-level characterization of the binders was described as internally consistent, the mechanical analogies applied to the F protein were deemed not applicable to the G protein architecture, and the authors asked that the work not be cited as a reference for the project. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.
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- europepmc
- last seen: 2026-05-20T01:45:00.602351+00:00
- unpaywall
- last seen: 2026-05-30T02:00:01.510937+00:00