WITHDRAWN: Beyond Binding Affinity: The Kinetic-Compatibility Hypothesis for Nipah Virus Neutralization: Decoding the Affinity Paradox Across 1,194 Designed Miniproteins

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AI-generated summary by claude@2026-07, 2026-07-14

This withdrawn manuscript investigated miniprotein binding kinetics for Nipah virus neutralization, but the data analyzed targeted the Attachment (G) glycoprotein, not the intended Fusion (F) protein.

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The manuscript proposed a kinetic-compatibility hypothesis to explain an “affinity paradox” in Nipah virus neutralization, using functional and sequence data from 1,194 designed miniproteins, and framing analysis in terms of mechanical transitions of the Nipah fusion (F) protein. The authors withdrew the work after identifying a fundamental error: the biological functional data they used were actually directed toward the Nipah attachment (G) glycoprotein rather than the F protein. Although the sequence-level characterization of the binders was described as internally consistent, the mechanical analogies applied to the F protein were deemed not applicable to the G protein architecture, and the authors asked that the work not be cited as a reference for the project. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Withdrawal Statement The authors have withdrawn their manuscript because of a fundamental error in the identification of the biological target protein. The analysis was originally framed around the mechanical transitions of the Nipah virus Fusion (F) protein; however, the empirical functional data utilized (from the 2025 AdaptyvBio competition) was directed toward the Attachment (G) glycoprotein. While the sequence-level characterization of the binders remains internally consistent, the mechanical analogies used are not applicable to the Attachment (G) protein architecture. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
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Withdrawal Statement The authors have withdrawn their manuscript because of a fundamental error in the identification of the biological target protein. The analysis was originally framed around the mechanical transitions of the Nipah virus Fusion (F) protein; however, the empirical functional data utilized (from the 2025 AdaptyvBio competition) was directed toward the Attachment (G) glycoprotein. While the sequence-level characterization of the binders remains internally consistent, the mechanical analogies used are not applicable to the Attachment (G) protein architecture. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author. Competing Interest Statement The authors have declared no competing interest.

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europepmc
last seen: 2026-05-20T01:45:00.602351+00:00
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