Relationship between gene polymorphism of CYP17 and the susceptibility of endometriosis and adenomyosis

Objective To study the relationship between gene polymorphism of CYP17 and the susceptibility of endometriosis and adenomyosis.Methods PCR-RFLP was used to analyze the polymorphism of CYP17 gene in 61 patients with endometriosis(EMs) and 59 with adenomyosis(Ad) and 65 healthy controls.Results There was no significant difference of the alleles and genotypes between endometriosis and adenomyosis.The frequencies of A1A1 genotype,A1A2 genotype and A1 allele were significantly higher in EMs and Ad groups than them in control group respectively.The relative risk suffered from endometriosis of A1A1 and A1A2 genotype was 4.615 and 3.467 times of the A2A2 genotype respectively,and that suffered from adenomyosis was 3.692 and 3.867 times of the A2A2 genotype respectively.Conclusion A1A1 and A1A2 genotype can increase the risk of susceptibility of endometriosis and adenomyosis,and A1 allele may be a risk factor for endometriosis and adenomyosis.The pathogenesis of endometriosis and adenomyosis was similar.