Bright and tunable far-red chemigenetic indicators
preprint
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CC-BY-NC-ND-4.0
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Researchers developed a new chemigenetic indicator platform using HaloTag and synthetic fluorophores to create bright, tunable far-red calcium and voltage sensors that detect single action potentials in neurons.
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Abstract
Functional imaging using fluorescent indicators has revolutionized biology but additional sensor scaffolds are needed to access properties such as bright, far-red emission. We introduce a new platform for ‘chemigenetic’ fluorescent indicators, utilizing the self-labeling HaloTag protein conjugated to environmentally sensitive synthetic fluorophores. This approach affords bright, far-red calcium and voltage sensors with highly tunable photophysical and chemical properties, which can reliably detect single action potentials in neurons.
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Source provenance
- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00
- unpaywall
- last seen: 2026-05-30T02:00:01.510937+00:00
License: CC-BY-NC-ND-4.0