Preoperative Erythrocyte Aggregation Exponent May Affect Postoperative Risk of Deep Venous Thrombosis in Patients With Primary Knee Osteoarthritis

Background: The factors leading to venous thromboembolism (VTE) have been known for a long time. Previous data has suggested a potential link between erythrocyte aggregation (EA) and deep vein thrombosis (DVT). Considering a relatively large number of patients who need total knee arthroplasty (TKA) surgery due to primary knee osteoarthritis (KOA), this study is tried to verify whether preoperative EA may have an effect on postoperative DVT after TKA in these patients. Methods: : A total of 750 KOA patients accepted unilateral TKA were enrolled from March 2010 to May 2020. On the third day after surgery, they all accepted the color Doppler ultrasound examination of both legs for deep veins and were subsequently divided into DVT and non-DVT groups. We made a thorough analysis to demonstrate the specific association of EA exponent before TKA and DVT risk after TKA. Results: : Low EA exponent was a significant risk factor for DVT in patients with primary KOA (p<0.05), especially in females after stratifying by gender (p<0.05). Conclusions: : Our results suggested that low EA before TKA was substantially associated with a high post-surgery DVT risk in primary KOA patients. Timely and effective anticoagulant therapy for such patients was required.