Selenium And Selenoproteins Implications In Breast Cancer Patients 

Background: Controversy surrounds the hypothetical relationship between Selenium levels and an increased risk of breast cancer. Since Selenium plays its role through various selenoproteins, including selenoprotein P and S, our study aimed to analyze Se, SelS, and SelP roles in breast cancer. Methods: our study considered 30 tumors and tumor margin tissues from breast cancer patients and blood serum from patients and control subjects. Selenium measurements were carried out using an atomic absorption spectrometer, and selenoproteins were measured by the ELISA method. Results: Selenium and Selenoprotein P and S have lower proportions in patients' serum. Also, SelP and SelS levels were lower in tumoral tissue. A NEGATIVE correlation between serum and tumor levels of SelS has existed, as well as tumor margin and tumoral tissue. Also, a NEGATIVE correlation between SelP concentrations in tumor margin and tumoral tissue was observed. The correlation between SelS and SelP levels in tumors was NEGATIVE, as well as their correlation in tumor margin tissues. Conclusion: Selenium and Selenoprotein P and S have lower proportions in patients' serum; thus, they are quickly emerging as fascinating diagnostic targets.