Acute pancreatitis

Frossard JL, Jean-Louis Frossard, Michael L Steer, Steer ML, Catherine M Pastor, Pastor CM
Lancet (London, England) · 2008 · vol. 371(9607) , pp. 143–52 · doi:10.1016/s0140-6736(08)60107-5 · PMID:18191686
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This abstract defines acute pancreatitis as an inflammatory pancreatic disease characterized by abdominal pain and elevated enzymes, outlining its causes, severity stratification, and multidisciplinary management strategies.

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This review article outlines the pathophysiology, diagnosis, and management of acute pancreatitis, emphasizing the distinction between interstitial edematous and necrotizing forms. The authors discuss the role of gallstones and alcohol as primary etiologies, alongside diagnostic markers such as serum amylase and lipase levels. Key therapeutic strategies include early fluid resuscitation, pain control, and the selective use of antibiotics only in cases of infected necrosis. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Acute pancreatitis is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom, and increased concentrations of serum amylase and lipase confirm the diagnosis. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications. Gallstone migration into the common bile duct and alcohol abuse are the most frequent causes of pancreatitis in adults. About 15-25% of pancreatitis episodes are of unknown origin. Treatment of mild disease is supportive, but severe episodes need management by a multidisciplinary team including gastroenterologists, interventional radiologists, intensivists, and surgeons. Improved understanding of pathophysiology and better assessments of disease severity should ameliorate the management and outcome of this complex disease.
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Acute pancreatitis ContributorsFrossard, Jean-Louis; Steer, Michael L.; Pastor, Catherine Published inLancet, vol. 371, no. 9607, p. 143-152 Publication date2008 Abstract Keywords - Acute Disease - Amylases/blood - Anti-Bacterial Agents/therapeutic use - Birnaviridae Infections/classification/metabolism/physiopathology - Cholecystectomy - Gallstones/complications/drug therapy - Humans - Incidence - Infectious pancreatic necrosis virus/pathogenicity - Lipase/blood - Pancreatitis/diagnosis/physiopathology/therapy - Severity of Illness Index UNIGE affiliation entities UNIGE research groups Citation (ISO format) FROSSARD, Jean-Louis, STEER, Michael L., PASTOR, Catherine. Acute pancreatitis. In: Lancet, 2008, vol. 371, n° 9607, p. 143–152. doi: 10.1016/S0140-6736(08)60107-5 Main files (1) Article (Accepted version) Identifiers - PID : unige:793 - DOI : 10.1016/S0140-6736(08)60107-5 - PMID : 18191686 Journal ISSN0140-6736

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MeSH descriptors

Amylases Birnaviridae Infections Infectious pancreatic necrosis virus Lipase Pancreatitis Pancreatitis Pancreatitis Pancreatitis Acute Disease Amylases Anti-Bacterial Agents Anti-Bacterial Agents Birnaviridae Infections Birnaviridae Infections Birnaviridae Infections Cholecystectomy Gallstones Gallstones Gallstones Humans

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europepmc
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pubmed
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License: CC-BY-4.0