SYMPATHOVAGAL EQUILIBRIUM ANALYSIS IN PATIENTS WITH COVID

SYMPATHOVAGAL EQUILIBRIUM ANALYSIS IN PATIENTS WITH COVID | SciELO Preprints window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-3TT8HYRH0Y'); Open Menu Registrar-se Acesso English Español Ir para o conteúdo principal Ir para o menu de navegação principal Ir para o rodapé Preprints Submissão Áreas do Conhecimento Ciências Agrárias Ciências Biológicas Ciências da Saúde Ciências Exatas e da Terra Ciências Humanas Ciências Sociais Aplicadas Engenharias Linguística, letras e artes Educação em Revista Memórias do Instituto Oswaldo Cruz 47º Encontro Anual da ANPOCS 48º Encontro Anual da ANPOCS 49º Encontro Anual da ANPOCS Sobre Sobre o Servidor Declaração de Privacidade Atualizações do Sistema Contato FAQ Ética no SciELO Preprints Avaliação de preprints Anotações em preprints (via Hypothesis) Avalie um preprint preLights Notícias Início / Ciências da Saúde Preprint / Versão 1 SYMPATHOVAGAL EQUILIBRIUM ANALYSIS IN PATIENTS WITH COVID article.authors6a55eee525ac6 Gonzalo Romagnoli Hospital Iturraspe .st0{fill:#A6CE39;} .st1{fill:#FFFFFF;} https://orcid.org/0000-0002-4312-1713 Hector Mario Musacchio Hospital JB Iturraspe .st0{fill:#A6CE39;} .st1{fill:#FFFFFF;} https://orcid.org/0000-0001-6409-725X Delfina Godano Hospital JB Iturraspe .st0{fill:#A6CE39;} .st1{fill:#FFFFFF;} https://orcid.org/0000-0002-4595-5842 María Florencia Cogliano Hospital JB Iturraspe Federico Barbone Hospital JB Iturraspe .st0{fill:#A6CE39;} .st1{fill:#FFFFFF;} https://orcid.org/0000-0003-3407-9733 Hugo Juan Damián Miño Hospital JB Iturraspe Florencia Debona Hospital JB Iturraspe .st0{fill:#A6CE39;} .st1{fill:#FFFFFF;} https://orcid.org/0000-0003-4781-0046 DOI: https://doi.org/10.1590/SciELOPreprints.3038 Palavras-chave: baroreflex, covid-19, dysautonomia, heart rate Resumo Background: At the end of 2019, a hitherto unknown coronavirus was identified in Wuhan (China) it was called SARS CoV-2 and the disease caused by it was named COVID-19. With the increase in cases an unusual manifestation for this type of virus began to appear: anosmia and dysgeusia, of uncertain etiology, which it could be an autonomic alteration, more precisely in the baroreflex. In this context, it seems likely that subclinical manifestations of baroreflex involvement occur. The regulation of the baroreflex is carried out by the vegetative nervous system through the balance between sympathetic and parasympathetic activity. The objective of this study is to verify whether patients with COVID-19 present alteration of this mechanism by means of ECG Holter recording Material and methods: the study design was cross-sectional, observational, descriptive, prospective inclusion and the sampling was non-probabilistic of convenience. Patients were included if they had a confirmed diagnosis of COVID-19 admitted to the Internal Medicine Service of JB Iturraspe Hospital in Santa Fe city, Argentina, in the period from May 10 to July 20, 2021. An ECG Holter recording was performed at rest for 5 minutes, determining the variables of the frequency domain using Fourier transform analysis through Kubios. Data are presented for frequency measures of HRV: low-frequency power (LF), and high-frequency power (HF) and normalized unit LFnu, HFnu. Were excluded patients with a diagnosis of diabetes mellitus of more than 5 years of evolution, medicated with beta-blockers or with a history of irradiation in the neck Results: 68 patients were studied. 62% were men 38% were women. The mean age was 48.9 ± 13.3 years. The median systolic blood pressure (SBP) was 120 mmHg (95 to 170) and the diastolic blood pressure (DBP) 80 mmHg (60 -110). The heart rate was 76 ± 13 beats per minute and the respiratory rate was 24 (16 to 40). Anosmia was observed in 22% (n = 15) and dysgeusia in 19% (n = 13). The variables of the analysis in the frequency domain were: LF 135.8 ms2 (13.7 - 2861.7); HF, 89.04 ms2 (4.14-5234.4), LFnu 57.57 ± 22.39, HFnu 43.18 ± 22.64. LF / HF ratio 2.1 ms2 ± 2.09. 41.2% (n = 28) of the patients had a high LF / HF ratio (> 2). Discussion: The high and low frequency components known as HF (High Frequency) representing predominantly parasympathetic function, and LF (Low Frequency) which is both sympathetic and parasympathetic activity; can be obtained through the analysis in the frequency domain. The relationship between these two elements would thus represent the sympatho-vagal balance and is expressed as the LF / HF ratio. We observed that 41.2% of the studied patients showed elevated LF / HF ratio Conclusion: The 41.2% of the patients hospitalized with COVID-19 presented with an increase in the LF / HF ratio and this result could be interpreted as an alteration in autonomic function. Downloads Os dados de download ainda não estão disponíveis. Biografia do Autor Gonzalo Romagnoli, Hospital Iturraspe Romagnoli, Gonzalo. Hospital J. B. Iturraspe Hector Mario Musacchio, Hospital JB Iturraspe Musacchio, Hector M. CONICET – Hospital J. B. Iturraspe Delfina Godano, Hospital JB Iturraspe Godano, Delfina. Hospital J. B. Iturraspe – Universidad Nacional del Litoral María Florencia Cogliano, Hospital JB Iturraspe Cogliano, Florencia. Hospital J. B. Iturraspe Federico Barbone, Hospital JB Iturraspe Barbone, Federico. Hospital J. B. Iturraspe Hugo Juan Damián Miño, Hospital JB Iturraspe Miño, Hugo J. D. Hospital J. B. Iturraspe Florencia Debona, Hospital JB Iturraspe Debona, Florencia. Hospital J. B. Iturraspe PDF (Inglês) Enviado 07/10/2021 Postado 21/10/2021 Como Citar SYMPATHOVAGAL EQUILIBRIUM ANALYSIS IN PATIENTS WITH COVID. (2021). Em SciELO Preprints . https://doi.org/10.1590/SciELOPreprints.3038 Formatos de Citação ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Baixar Citação Endnote/Zotero/Mendeley (RIS) BibTeX Série Ciências da Saúde Copyright (c) 2021 Gonzalo Romagnoli, Hector Mario Musacchio, Delfina Godano, María Florencia Cogliano, Federico Barbone, Hugo Juan Damián Miño, Florencia Debona Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License . .citations-container { overflow-y: auto; overflow-x: hidden; max-height: 1000px; } Plaudit Aviso de preprints Preprints são manuscritos não avaliados por um periódico científico ou já avaliados mas em processo de publicação. .block_announcements_article:not(:last-child) { padding-bottom: 1.5em; border-bottom: 1px solid; } .block_announcements_article { text-align: left; } .block_announcements #show-all{ font-style: italic; } Notícias SciELO Preprints adota obrigatoriedade de declaração de disponibilização de dados de pesquisa 19 agosto 2025 A partir de 1º de setembro de 2025 os manuscritos submetidos ao SciELO Preprints devem incluir uma declaração de disponibilidade de dados informando sobre onde e como os dados da pesquisa que deram origem ao artigo podem ser acessados. 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