Influencing Factor Analysis of Different Ovarian Stimulation Programs on the Outcome of Assisted Reproductive Technology in Patients with Endometriosis

Objective:To investigate the impact of different varian stimulation programs on the pregnancy outcome of assisted reproductive technology in patients with endometriosis.Methods:262 cycles of in vitro fertilization-embryo transfer(IVF-ET) outcomes in patients with endometriosis treated in First Affiliated Hospital of Anhui Medical University Reproductive Medicine Center from January 2008 to March 2010 were retrospectively analyzed.According to different controlled ovarian hyperstimulation(COH)programs,the cycles were divided into three groups,A group for the super prolonged therapy group,B group for the short-therapy group,C group for the prolonged therapy group.Patient age,infertility type,infertility duration,serum CA125 before down regulation,basic FSH,LH,E2 levels,basic sinus follicle numbers,Gn start dosage,Gn duration,Gn total dosage,E2,P,LH levels at retrieval day,endometrial thickness,retrieved numbers of oocyte,embryo quality,clinical pregnancy rate,and the relationship of serum CA125 after down regulation in group A and the clinical pregnancy rate,were all compared among the three groups.Results:①The mean age of group B was older than that of group A and group C(P0.05),but the infertility type and duration were not statistically different among the three groups(P0.05).②The basic level of FSH,Gn start dosage,LH level on retrieval day for group B were higher than those for group A and C(P0.05).The basic sinus follicle number,Gn duration,Gn total dosage,endometrial thickness on retrieval day and the number of retrieved oocyte for group B were less than those for group A and C(P0.05).The CA125 level before down regulation in group A was greater than that in group B and C(P0.05).③ The pregnancy rate when CA125 ≤ 10 KU/L(40.91%)after down regulation in group A was quite different from that when CA125 at 10~20 KU/L or 20 KU/L(18.31% and 17.65%)(P0.05).Conclusions:For mild endometriosis,early diagnosis and choice of assisted reproductive technology can effectively increase the clinical pregnancy rate.For moderate and severe endometriosis,when choosing super prolonged therapy program,checking serum CA125 can assist the judgement of pregnancy rate.