Early diagnosis by mNGS could improve the prognosis for severe leptospirosis patients

Early diagnosis by mNGS could improve the prognosis for severe leptospirosis patients | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Early diagnosis by mNGS could improve the prognosis for severe leptospirosis patients Xuqin Jiang#, Hui Jiang#, Yingying Xiong#, Ming Fang#, Bei Geng, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2108428/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purposes To evaluate the diagnostic efficiency of metagenomics next generation sequencing (mNGS) assay in severe leptospirosis and its role on prognosis. Methods We retrospectively reviewed the medical records of patients with confirmed leptospirosis from Jan. 1, 2019 to Dec. 31, 2021 from three hospitals. Detailed data including socio-demographic data, clinical manifestations, laboratory examination results, CT images etc. were collected and analyzed. Results Six severe cases were included in this study. All were diagnosed by positive mNGS results. Three of the patients were also polymerase chain reaction examined and presented negative results. Five patients were diagnosed by mNGS assay within two or three days and antibiotics were down-graded to ceftriaxone in them. All of them were cured finally. One case, who was diagnosed by mNGS late on day 5, died. Conclusions mNGS is highly efficient in diagnosing leptospirosis and could possibly reduce the mortality rate if used at an early stage. General Microbiology Metagenomics next generation sequencing Leptospirosis Diagnosis Prognosis Treatment Figures Figure 1 Introduction Leptospirosis is a tropical disease world-widely and the leading zoonotic cause of morbidity and mortality. It is estimated that 1.03 million people suffer from and 59,800 die from the disease annually. Reported mortality of leptospirosis varies from about 4%-50% in severe cases [1, 2]. Even intensive care unit supported, the case fatality rate of severe leptospirosis can be agonizing high. In a report from Sri Lanka, forty-two severe patients with confirmed diagnosis of leptospirosis presented a case fatality rate as high as 44.4%[3]. The mortality remained 4% at the lowest even patients were intensive care unit admitted, mechanical ventilation supported, and supplementary treatment administrated in Australia[4]. Apparently, to further reduce the mortality is clinically urgent and meaningful considering the high morbidity of the disease. Many factors are involved in the prognosis of the disease yet which one plays the most important or crucial remains unknown. Researches demonstrated that the prognosis of leptospirosis depended on whether a diagnosis was made promptly, antibiotics timely applied, important organ function protected, etc[5]. Theoretically, the management and treatments are usually controllable after admission. Therefore, early diagnosis and followed adequate treatment should deserve more attentions as a postponed diagnosis could yield delayed treatment and treatment failure[6]. Unfortunately, the delay of diagnosis of leptospirosis is rather common. Patients usually start with fever and other non-specific symptoms, which are often overlapped with that of other febrile illnesses. Therefore, the diagnosis could not be established by clinical manifestations merely and a confirmative laboratory examination is usually needed. However, conventional laboratory tests for leptospirosis are not efficient in whole. Leptospira culture is technically difficult due to the demand of special growth media[7]and the long incubation time needed. Serological test like microscopic agglutination test (MAT) can detect against live leptospirosis reference serovars in the blood sample but poorly efficient. Besides, the detection of serum antibody of leptospirosis could not tell a acute infection from previous silent ones[5]. Polymerase chain reaction (PCR) can detect leptospira in blood and urine at a relatively early stage, allowed an increasing of diagnosis by 16.1% compared with the traditional serologic tests[8], especially for patients in the early stage without micro-agglutination detectable antibodies[9]. But due to the limitation of variable primes, PCR remained an unsatisfactory method either. Even combined with MAT, the diagnostic efficiency was fairly poor[5]. Metagenomics next generation sequencing (mNGS) is a new technology for detecting unknown micro pathogens. With an extreme high efficiency, it has been used for identifying pathogens and performed prominent in determining complicated and rare infections. For example, mNGS performed well in diagnosing pneumocystis jiroveci pneumonia in patients after organ transplantation[10]. However, there are rare studies regarding the use of mNGS in leptospirosis diagnosis, except sporadic single case reports recently presented their successful endeavor in this field[5]. Here, we present the outcomes of a group of severe cases who were diagnosed at different stage of the disease using mNGS and treated against leptospira. We believe the conclusions of this study would be a meaningful reference for diagnosing and treating leptospirosis in practice. Materials And Methods Methodology We reviewed retrospectively the illness records about confirmed leptospirosis cases in the past three years from three hospitals. Data were collected from medical record bank and anonymity was ensured at all stages. The study was carried out in accordance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of The Affiliated First Hospital of USTC (Approval No: 2022-RE-067). The demand for patient consent was waived due to the nature of a retrospective study. Data collection The medical records of patients with confirmed leptospirosis in the Affiliated First Hospital of USTC, Wanbei Coal and Power Group General Hospital, and The First Affiliated Hospital of Anhui University of Science and Technology from Jan. 1, 2019 to Dec. 31, 2021 were traced. Detailed data including socio-demographic data, clinical manifestations, laboratory examination results including full blood count, extent of organ involvement like hepatic and renal function parameters, coagulation profile, C-reactive protein (CRP), procalcitonin (PCT), arterial blood gas analysis, diagnostic method used, treatment including antibiotic therapy, mechanical ventilation support, outcomes, etc were collected. Laboratory results on the first day of presentation or the first time after admission were extracted. The CT images were retrieved by searching the CT data bank. CT images were defined to the images on the first day or at the first time and images after treatment or before discharge. Sample Processing and DNA Extraction Volume of 5 ml of blood was drawn from patients and stored at room temperature for 3-5 min and then centrifuged at 4,000 rpm for 10 min at 4℃. Plasma samples were obtained and transferred to new sterile tubes. Volumes of 2.5 ml of bronchoalveolar lavage fluid(BALF) were collected from patients.Approximately, 0.6-ml sample and 250ml 0.5mm glass bead were attached to a horizontal platform on a vortex mixer and agitated vigorously at 2,800–3,200 rpm for 30 min. Then, 7.2 ml lysozyme was added for wall-breaking reaction. DNA was extracted from 0.3 ml of plasma/BALF using the TIANamp Micro DNA Kit (DP316, TIANGEN BIOTECH, Beijing, China), according to the manufacturer’s operational manual. The extracted DNA specimens were prepared for the DNA libraries construction [11]. DNA Library Construction and Sequencing DNA library was constructed through DNA fragmentation, end-repair, adapter-ligation, and PCR amplification using MGIEasy Cell-free DNA Library PrepSet (MGI Tech). Agilent 2100 was used for quality control of the DNA libraries. Qualified libraries were pooled; DNA Nanoball (DNB) was made using single-stranded DNA circles and sequenced by MGISEQ-2000/NextSeq 550 platform [12]. Bioinformatics Analysis High-quality sequencing data were generated by removing low-quality, short reads (length < 35 bp) [13],followed by computational subtraction of human host sequences mapped to the human reference genome (hg19) using Burrows-Wheeler Alignment[14] .The remaining data by removal of low-complexity reads were classified by simultaneously aligning with Pathogen Metagenomics Database (PMDB), including bacteria, fungi, viruses, and parasites. The classification reference databases were downloaded from NCBI..The coverage ratio and the depth of each microorganism were calculated using BEDTools[15]. The criteria for an infectious pathogen by mNGS were defined routinely. Results In total, six patients with confirmed diagnosis of severe leptospirosis were included in this study: four from the Affiliated First Hospital of USTC, one from Wanbei Coal and Power Group General Hospital, and one from The First Affiliated Hospital of Anhui University of Science and Technology. The demographic features of the patients are shown in Table 1. It is noteworthy that within two or three days after admission, five of the six patients were diagnosed as leptospirosis by mNGS assay, promptly treated with aimed antibiotics, admitted to intensive care unit,, mechanical ventilation supported, and gradually fully recovered, while case 5, who was diagnosed on day five after admission, died although ICU admitted. Clinical manifestations Six patients were all adults aged about sixty. All patients sought medical treatment within a week. Of them, two patients had a history of contacting river water in the past two weeks as washing injured hand in the river and fishing, separately. Fever, chest distress, and dyspnea presented in all the patients. Shock was seen in five of the patients. Hemoptysis appeared in four cases. Jaundice happened in two patients. Specific symptoms of leptospirosis like conjunctival suffusion were seen in case 4 and myalgia in case 1, 5, and 6, respectively. All patients were ranked the severe cases clinically. The symptoms and signs of patients are summarized in Table 1. Laboratory examinations Blood routine examinations revealed significant abnormalities in the peripheral blood. White blood cell count and neutrophils increased remarkably in all patients. In all cases, anemia to some degree was noted. Severe thrombocytopenia appeared in most cases except case 4. Biochemistry examinations showed mild to severe multi-organ dysfunction in each patient. Blood gas analysis revealed lowered PaO2/FiO2 (mmHg) and respiratory failure. All patients presented a rather high CRP level. Urine erythrocytes were seen in almost all cases. See Table 2. mNGS was performed in five of the patients within two days after admission. mNGS revealed leptospiral infection and the diagnose of leptospirosis was established within two or three days after admission. For case 5, mNGS was performed late on day four and got the positive result on day five after admission. It is worth noting that, in case 1, 3 and 6, both mNGS and PCR assays were performed, and mNGS presented positive result of leptospira infection while PCR reported negative. Besides, mNGS reported aspergillus oryzae and roseomonas as the co-morbidity pathogens in case 1 and 3, respectively. Routine blood culture and sputum culture did not reveal any significant pathogenic microorganisms. See Table 3. Image abnormalities All patients had abnormal chest images at admission. Typical pulmonary inflammation and hemorrhage as bilateral diffuse infiltration and patch shadows were noted. After treatment, chest images ameliorated in all patients. The changes were in accordance with the alleviation of clinical presentations synchronously. Figure 1 showed the representative changes of CT image in a patient before and after treatment. Treatment procedures and outcomes Five of the six patients were diagnosed within two or three days after admission and immediately treated accordingly. When mNGS results revealed leptospira as the pathogen of infection, modulation and downgrade of antibiotics were immediately administered. The patients were given ceftriaxone immediately. Broad spectrum antibiotics were ceased. In case 1, cefoperazone sulbactam was replaced by ceftriaxone and an extra antibiotics voriconazole was added due to a suspected concomitant infection. In case 2, 3, 4, and 6, antibiotics was down-graded from carbapenems to ceftriaxone. All patients were admitted into intensive care unit and received invasive mechanical ventilation for 3 to 6 days. In addition, other supportive treatments were also given separately depending on the individual conditions of each patient. The duration of hospitalization ranged from 6 to 18 days. Five patients were finally cured and completely recovered. Unfortunately, case 5, who was diagnosed on day 5, was an exception. The patient had shock, dyspnea , hemoptysis , and very high BNP levels. He was initially diagnosed as severe community acquired pneumonia with MODs, septic shock and treated with meropenem and moxifloxacin. The diagnosis of leptospirosis was determined by mNGS late on day five and the patient died on that day before the diagnosis reports. See Table 4. Discussion Leptospirosis is a widely distributed zoonosis with considerable fatality[ 16 ]. A certain part of patients will develop severely and even die at a high fatality rate[ 3 , 17 ], especially in the un-treated patients[ 18 ]. Many factors are involved in the prognosis of the disease[ 19 ]. Among them, early diagnosis is an important one. Unfortunately, conventional laboratory diagnostic methods are limited in efficiency and promptness. In this study, mNGS was proved highly efficient in diagnosing leptospirosis. The diagnosis was quickly established within one or two days using mNGS in most of the patients. Treatment was modulated consequently right after the diagnosis establishment and those patients were all cured. The clinical manifestations of leptospirosis could vary from mild illness to severe life-threatening ones. In most patients, the presentations are mild and self-limiting. But in some others it could be severe or even mortal[ 16 ], yielding a rather high mortality. Patients developed MODs could die at 44.4% even admitted to critical care settings[ 5 ]. Patients complicated by pulmonary hemorrhages and acute respiratory distress syndrome (ARDS) could have a very high mortality even respiratory support like extracorporeal membrane oxygenation was applied[ 20 ]. In a report from Australia, 37/55 (67%) patients developed moderate to severe acute respiratory distress syndrome, 32/55 (58%) had pulmonary hemorrhage. Even intensive care unit admitted, mechanical ventilation supported, 4% patients still died[ 5 ]. In our study, all patients presented MODs symptoms like shock, dyspnea, lowered PaO2/FiO2 (mmHg) and respiratory failure, jaundice etc. Laboratory examinations revealed MODs symbols including thrombocytopenia, acute liver and kidney injuries, coagulation parameters and blood gas abnormalities. Most patients presented CT abnormalities like diffuse infiltration and patch shadows, implying an existing pulmonary inflammation and hemorrhage, as shown in Fig. 1A and B. These indicated that these patients were in severe status in disease degree. Research pointed out that early diagnosis was crucial for the prognosis of the patients and a delayed antibiotic therapy might increase the fatality[ 5 ]. However, the diagnosis of leptospirosis remains a challenge because the diagnosis mainly depends on laboratory examinations instead of clinical manifestations. Unfortunately, conventional examination methods including ELISA, dual MAT, and PCR are rather limited in their diagnostic efficiency[ 5 ]. A large scale study enrolled 1,734 cases of confirmed 591 (34.1%) and 297 (17.1%) “probable” leptospirosis revealed that whole blood quantitative PCR (qPCR) identified the most cases (322/540 (60%) ) but missed 40, acute sample MAT missed 80% (409/510); paired serum sample MAT missed 58% (98/170)[ 5 ]. In our study, PCR was conducted in three patients and revealed negative results. Apparently, although those techniques could facilitate the diagnosis in some cases, they are not efficient in whole. Better methods are urgent needed[ 21 ]. mNGS, a molecular diagnostic tool developed in recent years has been used in clinical practice[ 22 , 23 ]. Research showed that mNGS was highly efficient in revealing rare pathogens[ 5 ]. It has been used especially in complicated infection diagnostics to identify the genomic characterization of various specific pathogen directly from various different specimens[ 24 ]. Recently, a few researchers tried mNGS in diagnosing leptospirosis. In a report of a case of patient, the researchers diagnosed leptospirosis successfully using mNGS although the patient died eventually[ 25 ]. In another case report, the researchers established the diagnosis of leptospirosis using mNGS assay and cured the patient successfully[ 5 ]. In our study, six cases of patients were all diagnosed by mNGS assay after admission. The results were often obtained quickly a day after blood or BALF sample collection. It is noteworthy that three of the patients were also examined by PCR but revealed negative results. Many factors affect the prognosis of patients. Due to the limited sensitivity of all three conventional diagnostic tests, clinicians had been suggested with an empirical treatment for suspected cases of leptospirosis[ 26 ]. In fact, appropriate antibiotic administration is one of the crucial factors that deciding the prognosis of the patients. Once the diagnosis was established, adequate antibiotics treatment are needed promptly besides other routine measures like intensive care support if necessary. Doxycycline and penicillin was standard therapy in early leptospirosis treatment while ceftriaxone was considered the antibiotics of choice in late and severe disease in the past decades[ 7 ]. In our study, ceftriaxone was given immediately when the diagnosis was established in the five early diagnosed patients. Two of the patients down-graded the antibiotics from imipenem-cilastatin sodium, one from meropenem and vancomycin, acyclovir, and the other case from meropenem to ceftriaxone, see table 4. After treatment, clinical manifestations of the patients were significantly attenuated. The CT image abnormalities alleviated in consistent with the attenuation of severity of dyspnea, chest tightness, hemoptysis, and abnormal blood gas changes, as shown by Fig. 1. Apparently, an in time diagnosis is beneficial to adequate antibiotics choice. The down-grade of antibiotics from broad-spectrum antibiotics could possibly lower the risks to multi-resistance to antibiotics and opportunistic secondary infections, and reduce financial expenses in these patients. On the early diagnose and adequate antibiotics administration, five of the patients were cured and discharged eventually. Contrary to those patients, case 5 was diagnosed as leptospirosis late on day 5 after admission. He had been treated with meropenem and moxifloxacin after admission and died on day five. In summary of these cases, it is reasonable to deduce that early diagnosis and appropriate antibiotics administration are crucial to the prognosis of the disease. Substantially, although the case number was somewhat limited, our study demonstrated the potency of mNGS for diagnosing leptospirosis and significance of early diagnosis. Limitations are obvious in this report. This is a retrospective study. Factors involved in deciding the treatment outcomes could not been assessed concisely and accurately. Secondly, the number of patients was fairly limited and the severity of each patient could be different. We could not come to a strong and solid conclusion about the role of in time treatments on the prognosis in those cured and the one died. Thirdly, mNGS method needs specific equipments and somewhat expensive, which will limit its application in the resource limited settings. Apparently, although most patients were diagnoses by mNGS and subsequently cured successfully in this study, prospective studies enrolling a significant number of patients would be more convincing. In summary, compared with the conventional diagnostic methods, mNGS is a promising method which is sensitive, highly efficient, and prompt in diagnosing leptospirosis. The technique could help physicians to establish the diagnosis accurately and timely, take proper treatment measures, and possibly reduce the mortality rate. A timely diagnosis and prompt specific treatment might reduce the death rate of leptospirosis substantially. Prospective studies enrolling considerable number of patients are expected. References Wang H, Lee M, Chen Y, Hsueh P, Chang S (2020) Factors associated with severity and mortality in patients with confirmed leptospirosis at a regional hospital in northern Taiwan. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 53 (2):307–314 Fann R, Vidya R, Chong H, Indralingam V, Christopher Chan W (2020) Clinical presentations and predictors of mortality for leptospirosis - A study from suburban area in Malaysia. The Medical journal of Malaysia 75 (1):52–56 Weeratunga P, Fernando S, Sriharan S, Gunawardena M, Wijenayake S (2015) Determinants of mortality and impact of therapy in patients with leptospirosis admitted for intensive care in a Sri Lankan hospital–a three year retrospective study. Pathogens and global health 109 (8):387–394 Smith S, Liu Y, Carter A, Kennedy B, Dermedgoglou A, Poulgrain S, Paavola M, Minto T, Luc M, Hanson J (2019) Severe leptospirosis in tropical Australia: Optimising intensive care unit management to reduce mortality. PLoS Negl Trop Dis 13 (12):e0007929 Noda A, Grillová L, Mariet J, Paiffer N, Ruiz Y, Rodríguez I, Echevarría E, Obregón A, Lienhard R, Picardeau M (2020) A first insight into the genomic diversity of Leptospira strains isolated from patients in Cuba. PLoS One 15 (2):e0229673 Fernando S, Cardinal P, Brindley P (2017) Hypoxemic Respiratory Failure from Acute Respiratory Distress Syndrome Secondary to Leptospirosis. Case reports in critical care 2017:9062107 Faucher J, Hoen B, Estavoyer J (2004) The management of leptospirosis. Expert Opin Pharmacother 5 (4):819–827 Zubach O, Semenyshyn O, Vasiuynets L, Velychko O, Zinchuk A (2020) Application of PCR for Specific Diagnosis of Leptospirosis in Humans in Ukraine. Pol J Microbiol 69 (4):421–426 Fonseca CA, Teixeira M, Romero E, Tengan F, Silva M, Shikanai-Yasuda M (2006) Leptospira DNA detection for the diagnosis of human leptospirosis. The Journal of infection 52 (1):15–22 Lu X, Zhang J, Ma W, Xing L, Ning H, Yao M (2022) Pneumocystis Jirovecii Pneumonia Diagnosis Metagenomic Next-Generation Sequencing. Frontiers in medicine 9:812005 Long Y, Zhang Y, Gong Y, Sun R, Su L, Lin X, Shen A, Zhou J, Caiji Z, Wang X, Li D, Wu H, Tan H (2016) Diagnosis of Sepsis with Cell-free DNA by Next-Generation Sequencing Technology in ICU Patients. Arch Med Res 47 (5):365–371 Jeon YJ, Zhou Y, Li Y, Guo Q, Chen J, Quan S, Zhang A, Zheng H, Zhu X, Lin J, Xu H, Wu A, Park SG, Kim BC, Joo HJ, Chen H, Bhak J (2014) The feasibility study of non-invasive fetal trisomy 18 and 21 detection with semiconductor sequencing platform. PLoS One 9 (10):e110240 Schmieder R, Edwards R (2011) Quality control and preprocessing of metagenomic datasets. Bioinformatics 27 (6):863–864 Li H, Durbin R (2010) Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26 (5):589–595 Quinlan AR, Hall IM (2010) BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26 (6):841–842 Ghazaei C (2018) LeptospiraPathogenic: Advances in understanding the molecular pathogenesis and virulence. Open veterinary journal 8 (1):13–24 Al Hariri Y, Sulaiman S, Khan A, Adnan A, Al Ebrahem S (2019) Mortality of leptospirosis associated acute kidney injury (LAKI) & predictors for its development in adults: A systematic review. Journal of infection and public health 12 (6):751–759 Taylor A, Paris D, Newton P (2015) A Systematic Review of the Mortality from Untreated Leptospirosis. PLoS Negl Trop Dis 9 (6):e0003866 Tan W, Soelar S, Mohd Suan M, Hussin N, Cheah W, Verasahib K, Goh P (2016) LEPTOSPIROSIS INCIDENCE AND MORTALITY IN MALAYSIA. The Southeast Asian journal of tropical medicine and public health 47 (3):434–440 Fabiani A, Dal Bo E, Di Bella S, Gabrielli M, Bologna A, Albert U, Sanson G (2021) Pica (Allotriophagy): An Underestimated Risk Factor for Severe Leptospirosis (Weil's Diseases)? Report of a Leptospira Septic Shock Successfully Managed with ECMO. Infect Dis Rep 13 (3):619–626 Marquez A, Djelouadji Z, Lattard V, Kodjo A (2017) Overview of laboratory methods to diagnose Leptospirosis and to identify and to type leptospires. International microbiology: the official journal of the Spanish Society for Microbiology 20 (4):184–193 Anonymous (2020) First NGS-based COVID-19 diagnostic. Nat Biotechnol 38 (7):777 Wu H, Wei J, Yu D (2020) Application of NGS in Diagnosis of Tuberculous Pleurisy with Multiple Negative Tests: A Case Report. Infection and drug resistance 13:3543–3550 Simner P, Miller S, Carroll K (2018) Understanding the Promises and Hurdles of Metagenomic Next-Generation Sequencing as a Diagnostic Tool for Infectious Diseases. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 66 (5):778–788 Lu J, Hu J, Yu S, Li L (2021) Next Generation Sequencing for Diagnosis of Leptospirosis Combined With Multiple Organ Failure: A Case Report and Literature Review. Frontiers in medicine 8:756592 Suputtamongkol Y, Pongtavornpinyo W, Lubell Y, Suttinont C, Hoontrakul S, Phimda K, Losuwanaluk K, Suwancharoen D, Silpasakorn S, Chierakul W, Day N (2010) Strategies for diagnosis and treatment of suspected leptospirosis: a cost-benefit analysis. PLoS Negl Trop Dis 4 (2):e610 Declarations Acknowledgements This work was supported by the National Natural Science Foundation of China (82000018), the Fundamental Research Fund for the Central Universities (WK9110000089). Author contribution Xuqin Jiang and Xiaodong Mei designed the study. Hui Jiang, Yingying Xiong , Ming Fang and Bei Geng took responsibility for the integrity of data and accuracy of the data analysis. Xuqin Jiang wrote the draft of the paper. Xiaodong Mei and Huimei Wu revised and edited the paper. All authors contributed to writing or reviewing the paper. Data availability Not applicable. Code availability Not applicable. Ethics approval The study was carried out in accordance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of The Affiliated First Hospital of USTC (Approval No: 2022-RE-067) .The demand for patient consent was waived due to the nature of a retrospective study. Consent to participate Written informed consent was obtained from all individuals involved in the study. Consent for publication All authors consent to publish. Conflict of interest The authors declare no competing interests. Tables Table 1 Demographic features and clinical presentations of the patients Case1 Case2 Case3 Case4 Case5 Case6 Gender Male Male Male Male Male Female Days from onset to admission 6 2 3 6 3 6 Age (yr) 63 77 58 60 62 55 Underlying disease s Malaria No Hypertension , Cerebral infarction No No No Consciousness Alert Light coma Light coma Alert Alert Coma Shock Yes Yes Yes No Yes Yes Fever Yes Yes Yes Yes Yes Yes Chest distress Yes Yes Yes Yes Yes Yes Dyspnea Yes Yes Yes Yes Yes Yes Hemoptysis Yes No No Yes Yes Yes Diarrhea No No Yes Yes No No Conjunctival suffusion No No No Yes No No Myalgia Yes No No No Yes Yes Arthralgia Yes No No No Yes No Jaundice No Yes No No Yes No Table 2 Laboratory examinations of the patients Case1 Case2 Case3 Case4 Case5 Case6 Ref. values Blood routine White blood cell (×10 9 /L ) 19.87 12.04 10.04 15.40 14.44 14.88 3.50 to 9.50 Neutrophil count(×10 9 /L ) 17.50 10.70 9.10 12.80 11.95 13.9 1.80 to 6.30 Hemoglobin (g/L) 108.0 66.0 120.0 75.0 117 107 130.0 to 175.0 Platelets (×10 9 /L ) 34 7 33 120 24 67 125-350 Biochemistry examinations ALT (U/L) 23.3 47.0 64.0 57.0 52.0 286.5 5.0-50.0 AST (U/L) 46.5 186.0 100.8 85.0 114.0 495.9 15.0-45.0 GGT (U/L) 41.0 30.0 35.9 45.0 44 46.2 10.0-60.0 Albumin (g/L) 35.7 24.2 28.3 25.6 21.0 40.7 40.0-55.0 Creatinine (umol/L) 164.0 230.0 134.1 89.0 302.0 405.7 57.0-111.0 Urea nitrogen (mmol/L) 28.80 15.30 7.90 9 . 10 19.60 18.60 3.10-8.00 Total bilirubin (umol/L) 21.6 67.5 27.3 17.0 44.0 14.0 3.4-21.0 Direct bilirubin (umol/L) 10.30 58.60 17.30 10.20 32.00 9.60 0.00-5.00 Indirect bilirubin (umol/L) 11.30 8.90 10.00 6.80 / 2.00 0.00-18.00 LDH (U/L) 1269 381 363 459 303 2766.2 120-250 CK U/L 136 3642 1180 98 497 940 39-308 Coagulation parameters Prothrombin time(seconds) 11.60 16.30 15.00 11.20 13.60 12.60 8.00-14.00 APTT (seconds) 20.30 54.50 39.20 43.90 33.8 0 35.70 20.00-40.00 INR 0.99 1.42 1.30 0.86 1.17 1.08 > 1.0 Troponin I (ug/L) 0.096 0.130 2.24 0.020 <0.05 1.710 0.000-0.034 Arterial blood gases analysis PH 7.495 7.2 7.26 7.439 7.05 7.395 7.35-7.45 PaO2 (mmHg) 72.2 45.9 91.30 58.1 180 90.3 70-100 PaCO2 (mmHg) 36.7 41.6 35.20 16.3 27 33.2 32-45 PaO2/FiO2 (mmHg) 180.5 218.6 130.4 96.8 180.0 180.6 >300 Others CRP (mg/L) 210.46 216.26 256.78 135.86 242.5 165.7 0.00 to 10.00 PCT (ng/ml) 26.020 11.176 >100 0.558 18.23 >100 0.000-0.500 Urine erythrocyte (/ul) 48.0 2915.0 799.9 / 296 182 0-17 NT-proBNP (pg/ml) 4305 28727 5579 1440 12179.9 8490 0-125,0-900.0 CD3+CD4+% 22.9 / 35.4 23.8 / 37.5 28.5-60.5 P-ANCA Negative Negative / Negative / Negative Negative C-ANCA Negative Negative / Negative / Negative Negative Table 3 Microbiological examination results of the patients Case1 Case2 Case3 Case4 Case5 Case6 mNGS Samples used BALF Blood Blood BALF Blood Blood Reads for leptospira 8 188233 22 1 2 7 Results judgment Positive Positive Positive Positive Positive Positive Others reported Aspergillus Negative Roseomonas Negative Negative Negative Days before sampling 1 0 1 2 4 1 Days before diagnosis 2 1 2 3 5 2 Blood PCR assay results Negative / Negative / / Negative Sputum culture Negative Negative Negative Negative Negative Negative Blood culture Negative Negative Negative Negative Negative Negative Table 4 Treatment modulation base on mNGS results and outcome of the patients Case1 Case2 Case3 Case4 Case5 Case6 Initial antibiotics regime Cefoperazone sulbactam Imipenem-Cilastatin Sodium Imipenem-Cilastatin Sodium Meropenem , Vancomycin , Acyclovir Meropenem , Moxifloxacin Meropenem Modulation on mNGS Ceftriaxone , Voriconazole Ceftriaxone Ceftriaxone Ceftriaxone / Ceftriaxone Admitted to ICU Yes Yes Yes Yes Yes Yes Invasive ventilation Yes Yes Yes Yes Yes Yes Ventilation time (days) 3 6 3 6 5 6 Days of hospitalization 12 13 6 18 5 16 Outcomes Cured Cured Cured Cured Died Cured Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2108428","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":140305683,"identity":"bdc7ef29-6808-440a-a991-2337e7c66677","order_by":0,"name":"Xuqin Jiang#","email":"","orcid":"","institution":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xuqin","middleName":"","lastName":"Jiang#","suffix":""},{"id":140305684,"identity":"f01499ac-1f34-45b0-870b-7bd46cd9814e","order_by":1,"name":"Hui Jiang#","email":"","orcid":"","institution":"Department of Pulmonary and Critical Care Medicine, Wanbei Coal and Power Group General Hospital, Suzhou, China","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hui","middleName":"","lastName":"Jiang#","suffix":""},{"id":140306349,"identity":"c7c66363-a4e2-45c9-970f-9167128d8ae1","order_by":2,"name":"Yingying Xiong#","email":"","orcid":"","institution":"Department of Pediatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yingying","middleName":"","lastName":"Xiong#","suffix":""},{"id":140306350,"identity":"a7b43f14-4b5a-4aae-94ba-21d7bd3baa2b","order_by":3,"name":"Ming Fang#","email":"","orcid":"","institution":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, China","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ming","middleName":"","lastName":"Fang#","suffix":""},{"id":140306351,"identity":"d530492b-cfd6-4dc0-b139-921bccf03c90","order_by":4,"name":"Bei Geng","email":"","orcid":"","institution":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Bei","middleName":"","lastName":"Geng","suffix":""},{"id":140306352,"identity":"07ac90cb-d702-4b3b-a994-c59c8daf0a15","order_by":5,"name":"Huimei Wu*","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAqUlEQVRIiWNgGAWjYFACHgaGDwwHwEwJorUwziBZCzMPSVoMbuQe3WxTcyfa4ADzwds8DHZ5RGjJS7udc+xZ7oYDbMnWPAzJxQS1mN3IMbudw3YYqIXHTBrowsQGorRY/ANp4f9GghbGNrAtbMRpsT/zxuxmb9/h3JmH2Ywt5xgkE9Yi2Z5jduPHt8O5fcebH954U2FHWAsCMIMIA+LVj4JRMApGwSjAAwAJK0Gp0AoWjgAAAABJRU5ErkJggg==","orcid":"","institution":"Department of Geriatric Respiratory and Critical Care, Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022.","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Huimei","middleName":"","lastName":"Wu*","suffix":""},{"id":140306353,"identity":"e323fe14-c3d9-43a3-9b26-e848666d010a","order_by":6,"name":"Xiaodong Mei*","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA+ElEQVRIiWNgGAWjYDACZiDmAbMYGx9AxQyI1tJsAFVNQAsDXAsDmwRRWgyOMz988Kbijt3a9ua2ap4/f+QZ2Ju3STDU3MGpRbKZzdhwzplnydvOHGy7zdtmYNjAc6xMguHYM5xa+JkZzKR52w4nm91IBGppMEhgkMgxk2BsOIxTCxsz+zeIlvsP24p5/gC1yL/Br4WfmQdsi53ZDcY2Zh42kC08+LVINvMUA/1yOMHsTGKz5Nw2Y8M2nrRii4RjuLUYnD++ERhih+3Njh9/+OHNHzl5fvbDG298qMGtBQYSG+C+AxEJBDUwMNgToWYUjIJRMApGKgAAfndQdUzXsKgAAAAASUVORK5CYII=","orcid":"","institution":"Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Xiaodong","middleName":"","lastName":"Mei*","suffix":""}],"badges":[],"createdAt":"2022-09-27 11:43:01","currentVersionCode":1,"declarations":{"humanSubjects":true,"vertebrateSubjects":false,"conflictsOfInterestStatement":true,"humanSubjectEthicalGuidelines":true,"humanSubjectConsent":true,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false,"coiExplicitlySet":false},"doi":"10.21203/rs.3.rs-2108428/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-2108428/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":27203596,"identity":"24c65aa4-c1be-438f-b3aa-c523edb358f3","added_by":"auto","created_at":"2022-09-30 17:51:36","extension":"tif","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":913013,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eRepresentative CT image changes before and after treatment of the patients. A and B: Bilateral diffuse infiltration and patch shadows were presented before the treatment; C and D: Ameliorated images after treatment.\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"Fig1.tif","url":"https://assets-eu.researchsquare.com/files/rs-2108428/v1/baf2073fc0fec1a02b844965.tif"},{"id":27203597,"identity":"ca9c3a3e-393d-4a82-9192-398db8eb57ae","added_by":"auto","created_at":"2022-09-30 17:51:40","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1752698,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-2108428/v1/69130771-bd53-4ef5-9ac6-40206cfee3ca.pdf"}],"financialInterests":"","formattedTitle":"\u003cp\u003e\u003cstrong\u003eEarly diagnosis by mNGS could improve the prognosis for severe leptospirosis patients\u003c/strong\u003e\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003eLeptospirosis is a tropical disease world-widely and the leading zoonotic cause of morbidity and mortality. It is estimated that 1.03 million people suffer from and 59,800 die from the disease annually. Reported mortality of leptospirosis varies from about 4%-50% in severe cases\u0026nbsp;[1, 2]. Even intensive care unit supported, the case fatality rate of severe leptospirosis can be agonizing high. In a report from Sri Lanka, forty-two severe patients with confirmed diagnosis of leptospirosis presented a case fatality rate as high as 44.4%[3]. The mortality remained 4% at the lowest even patients were intensive care unit admitted, mechanical ventilation supported, and supplementary treatment administrated in Australia[4]. Apparently, to further reduce the mortality is clinically urgent and meaningful considering the high morbidity of the disease.\u003c/p\u003e\n\u003cp\u003eMany factors are involved in the prognosis of the disease yet which one plays the most important or crucial remains unknown. Researches demonstrated that the prognosis of leptospirosis depended on whether a diagnosis was made promptly, antibiotics timely applied, important organ function protected, etc[5]. Theoretically, the management and treatments are usually controllable after admission. Therefore, early diagnosis and followed adequate treatment should deserve more attentions as a postponed diagnosis could yield delayed treatment and treatment failure[6]. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eUnfortunately, the delay of diagnosis of leptospirosis is rather common. Patients usually start with fever and other non-specific symptoms, which are often overlapped with that of other febrile illnesses. Therefore, the diagnosis could not be established by clinical manifestations merely and a confirmative laboratory examination is usually needed. However, conventional laboratory tests for leptospirosis are not efficient in whole. Leptospira culture is technically difficult due to the demand of special growth media[7]and the long incubation time needed. Serological test like\u0026nbsp;microscopic agglutination test (MAT) can detect against live leptospirosis reference serovars in the blood sample but poorly efficient. Besides, the detection\u0026nbsp;of\u0026nbsp;serum antibody of leptospirosis could not tell a acute infection from previous silent ones[5]. Polymerase chain reaction (PCR) can detect \u003cem\u003eleptospira\u003c/em\u003e in blood and urine at a relatively early stage, allowed an increasing of diagnosis by 16.1% compared with the traditional serologic tests[8], especially for patients in the early stage without micro-agglutination detectable antibodies[9]. But due to the limitation of variable primes, PCR remained an unsatisfactory method either. Even combined with MAT, the diagnostic efficiency was fairly poor[5].\u003c/p\u003e\n\u003cp\u003eMetagenomics next generation sequencing (mNGS) is a new technology for detecting unknown micro pathogens. With an extreme high efficiency, it has been used for identifying pathogens and performed prominent in determining complicated and rare infections. For example, mNGS performed well in diagnosing pneumocystis jiroveci pneumonia in patients after organ transplantation[10]. However, there are rare studies regarding the use of mNGS in leptospirosis diagnosis, except sporadic single case reports recently presented their successful endeavor in this field[5]. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eHere, we present the outcomes of a group of severe cases who were diagnosed at different stage of the disease using mNGS and treated against leptospira. We believe the conclusions of this study would be a meaningful reference for diagnosing and treating leptospirosis in practice.\u003c/p\u003e"},{"header":"Materials And Methods","content":"\u003cp\u003e\u003cstrong\u003eMethodology\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe reviewed retrospectively the illness records about confirmed leptospirosis cases in the past three years from three hospitals. Data were collected from medical record bank and anonymity was ensured at all stages. The study was carried out in accordance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of The Affiliated First Hospital of USTC (Approval No: 2022-RE-067). The demand for patient consent was waived due to the nature of a retrospective study. \u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData collection\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe medical records of patients with confirmed leptospirosis\u0026nbsp;in the Affiliated First Hospital of USTC, Wanbei Coal and Power Group General Hospital, and The First Affiliated Hospital of Anhui University of Science and Technology from Jan. 1, 2019 to Dec. 31, 2021 were traced. Detailed data including socio-demographic data, clinical manifestations, laboratory examination results including full blood count, extent of organ involvement like hepatic and renal function parameters, coagulation profile, C-reactive protein (CRP), procalcitonin (PCT), arterial blood gas analysis, diagnostic method used, treatment including antibiotic therapy, mechanical ventilation support, outcomes, etc were collected. Laboratory results on the first day of presentation or the first time after admission were extracted. The CT images were retrieved by searching the CT data bank. CT images were defined to the images on the first day or at the first time and images after treatment or before discharge. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSample Processing and DNA Extraction\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eVolume of 5 ml of blood was drawn from patients and stored at room temperature for 3-5 min and then centrifuged at 4,000 rpm for 10 min at 4℃. Plasma samples were obtained and transferred to new sterile tubes. Volumes of 2.5 ml of bronchoalveolar lavage fluid(BALF) were collected from patients.Approximately, 0.6-ml sample and 250ml 0.5mm glass bead were attached to a horizontal platform on a vortex mixer and agitated vigorously at 2,800\u0026ndash;3,200 rpm for 30 min. Then, 7.2 ml lysozyme was added for wall-breaking reaction. DNA was extracted from 0.3 ml of plasma/BALF using the TIANamp Micro DNA Kit (DP316, TIANGEN BIOTECH, Beijing, China), according to the manufacturer\u0026rsquo;s operational manual. The extracted DNA specimens were prepared for the DNA libraries construction\u0026nbsp;[11].\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDNA Library Construction and\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003cstrong\u003eSequencing\u003c/strong\u003e\u003cstrong\u003e\u003cbr\u003e\u0026nbsp;\u003c/strong\u003e\u0026nbsp; \u0026nbsp; DNA library was constructed through DNA fragmentation, end-repair, adapter-ligation, and PCR\u0026nbsp;amplification using MGIEasy Cell-free DNA Library PrepSet (MGI Tech). Agilent 2100 was used for quality control of the DNA libraries. Qualified libraries were pooled; DNA Nanoball (DNB) was made using single-stranded DNA circles and sequenced by MGISEQ-2000/NextSeq 550 platform\u0026nbsp;\u0026nbsp;[12].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eBioinformatics Analysis\u003c/strong\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eHigh-quality sequencing data were generated by removing low-quality, short reads (length \u0026lt; 35 bp) [13],followed by computational subtraction of human host sequences mapped to the human reference genome (hg19) using Burrows-Wheeler Alignment[14] .The remaining data by removal of low-complexity reads were classified by simultaneously aligning with Pathogen Metagenomics Database (PMDB), including bacteria, fungi, viruses, and parasites. The classification reference databases were downloaded from NCBI..The coverage ratio and the depth of each microorganism were calculated using BEDTools[15]. The criteria for an infectious pathogen by mNGS were defined routinely.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eIn total, six patients with confirmed diagnosis of severe leptospirosis were included in this study: four from the Affiliated First Hospital of USTC, one from Wanbei Coal and Power Group General Hospital, and one from The First Affiliated Hospital of Anhui University of Science and Technology. The demographic features of the patients are shown in Table 1. It is noteworthy that within two or three days after admission, five of the six patients were diagnosed as leptospirosis by mNGS assay, promptly treated with aimed antibiotics, admitted to intensive care unit,, mechanical ventilation supported, and\u0026nbsp;gradually fully\u0026nbsp;recovered, while case 5, who was diagnosed on day five after admission, died although ICU admitted.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical manifestations\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSix patients were all adults aged about sixty. All patients sought medical treatment within a week. Of them, two patients had a history of contacting river water in the past two weeks as washing injured hand in the river and fishing, separately. Fever, chest distress, and dyspnea presented in all the patients. Shock was seen in five of the patients. Hemoptysis appeared in four cases. Jaundice happened in two patients. Specific symptoms of leptospirosis like conjunctival suffusion were seen in case 4 and myalgia in case 1, 5, and 6, respectively. All patients were ranked the severe cases clinically. The symptoms and signs of patients are summarized in Table 1.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLaboratory examinations\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBlood routine examinations revealed significant abnormalities in the peripheral blood. White blood cell count and neutrophils increased remarkably in all patients. In all cases, anemia to some degree was noted. Severe thrombocytopenia appeared in most cases except case 4. Biochemistry examinations showed mild to severe multi-organ dysfunction in each patient. Blood gas analysis revealed lowered PaO2/FiO2 (mmHg) and respiratory failure. All patients presented a rather high CRP level. Urine erythrocytes were seen in almost all cases. See Table 2.\u003c/p\u003e\n\u003cp\u003emNGS was performed in five of the patients within two days after admission. mNGS revealed leptospiral infection and the diagnose of leptospirosis was established within two or three days after admission. For case 5, mNGS was performed late on day four and got the positive result on day five after admission. It is worth noting that, in case 1, 3 and 6, both mNGS and PCR assays were performed, and mNGS presented positive result of leptospira infection while PCR reported negative. Besides, mNGS reported\u0026nbsp;\u003ca href=\"javascript%3A;\"\u003easpergillus\u003c/a\u003e \u003ca href=\"javascript%3A;\"\u003eoryzae\u003c/a\u003e and roseomonas as the co-morbidity pathogens in case 1 and 3, respectively. Routine blood culture and sputum culture did not reveal any significant pathogenic microorganisms. See Table 3.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eImage abnormalities\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll patients had abnormal chest images at admission. Typical pulmonary inflammation and hemorrhage as bilateral\u0026nbsp;diffuse infiltration and patch shadows were noted. After treatment, chest images ameliorated in all patients. The changes were in accordance with the alleviation of clinical presentations synchronously. Figure 1 showed the representative changes of CT image in a patient before and after treatment.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment procedures and outcomes\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eFive of the six patients were diagnosed within two or three days after admission and immediately treated accordingly. When mNGS results revealed leptospira as the pathogen of infection, modulation and downgrade of antibiotics were immediately administered. The patients were given ceftriaxone immediately. Broad spectrum antibiotics were ceased. In case 1, cefoperazone sulbactam was replaced by ceftriaxone and an extra antibiotics voriconazole was added due to a suspected concomitant infection. In case 2, 3, 4, and 6, antibiotics was down-graded from carbapenems to ceftriaxone. All patients were admitted into intensive care unit and received invasive mechanical ventilation for 3 to 6 days. In addition, other supportive treatments were also given separately depending on the individual conditions of each patient. The duration of hospitalization ranged from 6 to 18 days. Five patients were finally cured and completely recovered. Unfortunately, case 5, who was diagnosed on day 5, was an exception. The patient had shock,\u0026nbsp;\u003ca href=\"javascript%3A;\"\u003edyspnea\u003c/a\u003e,\u0026nbsp;\u003ca href=\"javascript%3A;\"\u003ehemoptysis\u003c/a\u003e, and very high BNP levels. He was initially diagnosed as severe community acquired pneumonia with MODs, septic shock and treated with\u0026nbsp;\u003ca href=\"javascript%3A;\"\u003emeropenem\u003c/a\u003e and moxifloxacin. The diagnosis of leptospirosis was determined by mNGS late on day five and the patient died on that day before the diagnosis reports. See Table 4.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eLeptospirosis is a widely distributed zoonosis with considerable fatality[\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. A certain part of patients will develop severely and even die at a high fatality rate[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e], especially in the un-treated patients[\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. Many factors are involved in the prognosis of the disease[\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. Among them, early diagnosis is an important one. Unfortunately, conventional laboratory diagnostic methods are limited in efficiency and promptness. In this study, mNGS was proved highly efficient in diagnosing leptospirosis. The diagnosis was quickly established within one or two days using mNGS in most of the patients. Treatment was modulated consequently right after the diagnosis establishment and those patients were all cured.\u003c/p\u003e \u003cp\u003eThe clinical manifestations of leptospirosis could vary from mild illness to severe life-threatening ones. In most patients, the presentations are mild and self-limiting. But in some others it could be severe or even mortal[\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e], yielding a rather high mortality. Patients developed MODs could die at 44.4% even admitted to critical care settings[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. Patients complicated by pulmonary hemorrhages and acute respiratory distress syndrome (ARDS) could have a very high mortality even respiratory support like extracorporeal membrane oxygenation was applied[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. In a report from Australia, 37/55 (67%) patients developed moderate to severe acute respiratory distress syndrome, 32/55 (58%) had pulmonary hemorrhage. Even intensive care unit admitted, mechanical ventilation supported, 4% patients still died[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. In our study, all patients presented MODs symptoms like shock, dyspnea, lowered PaO2/FiO2 (mmHg) and respiratory failure, jaundice etc. Laboratory examinations revealed MODs symbols including thrombocytopenia, acute liver and kidney injuries, coagulation parameters and blood gas abnormalities. Most patients presented CT abnormalities like diffuse infiltration and patch shadows, implying an existing pulmonary inflammation and hemorrhage, as shown in Fig.\u0026nbsp;1A and B. These indicated that these patients were in severe status in disease degree.\u003c/p\u003e \u003cp\u003eResearch pointed out that early diagnosis was crucial for the prognosis of the patients and a delayed antibiotic therapy might increase the fatality[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. However, the diagnosis of leptospirosis remains a challenge because the diagnosis mainly depends on laboratory examinations instead of clinical manifestations. Unfortunately, conventional examination methods including ELISA, dual MAT, and PCR are rather limited in their diagnostic efficiency[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. A large scale study enrolled 1,734 cases of confirmed 591 (34.1%) and 297 (17.1%) \u0026ldquo;probable\u0026rdquo; leptospirosis revealed that whole blood quantitative PCR (qPCR) identified the most cases (322/540 (60%) ) but missed 40, acute sample MAT missed 80% (409/510); paired serum sample MAT missed 58% (98/170)[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. In our study, PCR was conducted in three patients and revealed negative results. Apparently, although those techniques could facilitate the diagnosis in some cases, they are not efficient in whole. Better methods are urgent needed[\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e].\u003c/p\u003e \u003cp\u003emNGS, a molecular diagnostic tool developed in recent years has been used in clinical practice[\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e, \u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. Research showed that mNGS was highly efficient in revealing rare pathogens[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. It has been used especially in complicated infection diagnostics to identify the genomic characterization of various specific pathogen directly from various different specimens[\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]. Recently, a few researchers tried mNGS in diagnosing leptospirosis. In a report of a case of patient, the researchers diagnosed leptospirosis successfully using mNGS although the patient died eventually[\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. In another case report, the researchers established the diagnosis of leptospirosis using mNGS assay and cured the patient successfully[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. In our study, six cases of patients were all diagnosed by mNGS assay after admission. The results were often obtained quickly a day after blood or BALF sample collection. It is noteworthy that three of the patients were also examined by PCR but revealed negative results.\u003c/p\u003e \u003cp\u003eMany factors affect the prognosis of patients. Due to the limited sensitivity of all three conventional diagnostic tests, clinicians had been suggested with an empirical treatment for suspected cases of leptospirosis[\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]. In fact, appropriate antibiotic administration is one of the crucial factors that deciding the prognosis of the patients. Once the diagnosis was established, adequate antibiotics treatment are needed promptly besides other routine measures like intensive care support if necessary. Doxycycline and penicillin was standard therapy in early leptospirosis treatment while ceftriaxone was considered the antibiotics of choice in late and severe disease in the past decades[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. In our study, ceftriaxone was given immediately when the diagnosis was established in the five early diagnosed patients. Two of the patients down-graded the antibiotics from imipenem-cilastatin sodium, one from meropenem and vancomycin, acyclovir, and the other case from meropenem to ceftriaxone, see table 4. After treatment, clinical manifestations of the patients were significantly attenuated. The CT image abnormalities alleviated in consistent with the attenuation of severity of dyspnea, chest tightness, hemoptysis, and abnormal blood gas changes, as shown by Fig.\u0026nbsp;1.\u003c/p\u003e \u003cp\u003eApparently, an in time diagnosis is beneficial to adequate antibiotics choice. The down-grade of antibiotics from broad-spectrum antibiotics could possibly lower the risks to multi-resistance to antibiotics and opportunistic secondary infections, and reduce financial expenses in these patients. On the early diagnose and adequate antibiotics administration, five of the patients were cured and discharged eventually. Contrary to those patients, case 5 was diagnosed as leptospirosis late on day 5 after admission. He had been treated with meropenem and moxifloxacin after admission and died on day five. In summary of these cases, it is reasonable to deduce that early diagnosis and appropriate antibiotics administration are crucial to the prognosis of the disease. Substantially, although the case number was somewhat limited, our study demonstrated the potency of mNGS for diagnosing leptospirosis and significance of early diagnosis.\u003c/p\u003e \u003cp\u003eLimitations are obvious in this report. This is a retrospective study. Factors involved in deciding the treatment outcomes could not been assessed concisely and accurately. Secondly, the number of patients was fairly limited and the severity of each patient could be different. We could not come to a strong and solid conclusion about the role of in time treatments on the prognosis in those cured and the one died. Thirdly, mNGS method needs specific equipments and somewhat expensive, which will limit its application in the resource limited settings. Apparently, although most patients were diagnoses by mNGS and subsequently cured successfully in this study, prospective studies enrolling a significant number of patients would be more convincing.\u003c/p\u003e \u003cp\u003eIn summary, compared with the conventional diagnostic methods, mNGS is a promising method which is sensitive, highly efficient, and prompt in diagnosing leptospirosis. The technique could help physicians to establish the diagnosis accurately and timely, take proper treatment measures, and possibly reduce the mortality rate. A timely diagnosis and prompt specific treatment might reduce the death rate of leptospirosis substantially. Prospective studies enrolling considerable number of patients are expected.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eWang H, Lee M, Chen Y, Hsueh P, Chang S (2020) Factors associated with severity and mortality in patients with confirmed leptospirosis at a regional hospital in northern Taiwan. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 53 (2):307\u0026ndash;314\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFann R, Vidya R, Chong H, Indralingam V, Christopher Chan W (2020) Clinical presentations and predictors of mortality for leptospirosis - A study from suburban area in Malaysia. The Medical journal of Malaysia 75 (1):52\u0026ndash;56\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eWeeratunga P, Fernando S, Sriharan S, Gunawardena M, Wijenayake S (2015) Determinants of mortality and impact of therapy in patients with leptospirosis admitted for intensive care in a Sri Lankan hospital\u0026ndash;a three year retrospective study. Pathogens and global health 109 (8):387\u0026ndash;394\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSmith S, Liu Y, Carter A, Kennedy B, Dermedgoglou A, Poulgrain S, Paavola M, Minto T, Luc M, Hanson J (2019) Severe leptospirosis in tropical Australia: Optimising intensive care unit management to reduce mortality. PLoS Negl Trop Dis 13 (12):e0007929\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eNoda A, Grillov\u0026aacute; L, Mariet J, Paiffer N, Ruiz Y, Rodr\u0026iacute;guez I, Echevarr\u0026iacute;a E, Obreg\u0026oacute;n A, Lienhard R, Picardeau M (2020) A first insight into the genomic diversity of Leptospira strains isolated from patients in Cuba. PLoS One 15 (2):e0229673\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFernando S, Cardinal P, Brindley P (2017) Hypoxemic Respiratory Failure from Acute Respiratory Distress Syndrome Secondary to Leptospirosis. Case reports in critical care 2017:9062107\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFaucher J, Hoen B, Estavoyer J (2004) The management of leptospirosis. Expert Opin Pharmacother 5 (4):819\u0026ndash;827\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eZubach O, Semenyshyn O, Vasiuynets L, Velychko O, Zinchuk A (2020) Application of PCR for Specific Diagnosis of Leptospirosis in Humans in Ukraine. Pol J Microbiol 69 (4):421\u0026ndash;426\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFonseca CA, Teixeira M, Romero E, Tengan F, Silva M, Shikanai-Yasuda M (2006) Leptospira DNA detection for the diagnosis of human leptospirosis. The Journal of infection 52 (1):15\u0026ndash;22\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLu X, Zhang J, Ma W, Xing L, Ning H, Yao M (2022) Pneumocystis Jirovecii Pneumonia Diagnosis Metagenomic Next-Generation Sequencing. Frontiers in medicine 9:812005\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLong Y, Zhang Y, Gong Y, Sun R, Su L, Lin X, Shen A, Zhou J, Caiji Z, Wang X, Li D, Wu H, Tan H (2016) Diagnosis of Sepsis with Cell-free DNA by Next-Generation Sequencing Technology in ICU Patients. Arch Med Res 47 (5):365\u0026ndash;371\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eJeon YJ, Zhou Y, Li Y, Guo Q, Chen J, Quan S, Zhang A, Zheng H, Zhu X, Lin J, Xu H, Wu A, Park SG, Kim BC, Joo HJ, Chen H, Bhak J (2014) The feasibility study of non-invasive fetal trisomy 18 and 21 detection with semiconductor sequencing platform. PLoS One 9 (10):e110240\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSchmieder R, Edwards R (2011) Quality control and preprocessing of metagenomic datasets. Bioinformatics 27 (6):863\u0026ndash;864\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLi H, Durbin R (2010) Fast and accurate long-read alignment with Burrows-Wheeler transform. Bioinformatics 26 (5):589\u0026ndash;595\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eQuinlan AR, Hall IM (2010) BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26 (6):841\u0026ndash;842\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eGhazaei C (2018) LeptospiraPathogenic: Advances in understanding the molecular pathogenesis and virulence. Open veterinary journal 8 (1):13\u0026ndash;24\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eAl Hariri Y, Sulaiman S, Khan A, Adnan A, Al Ebrahem S (2019) Mortality of leptospirosis associated acute kidney injury (LAKI) \u0026amp; predictors for its development in adults: A systematic review. Journal of infection and public health 12 (6):751\u0026ndash;759\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTaylor A, Paris D, Newton P (2015) A Systematic Review of the Mortality from Untreated Leptospirosis. PLoS Negl Trop Dis 9 (6):e0003866\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eTan W, Soelar S, Mohd Suan M, Hussin N, Cheah W, Verasahib K, Goh P (2016) LEPTOSPIROSIS INCIDENCE AND MORTALITY IN MALAYSIA. The Southeast Asian journal of tropical medicine and public health 47 (3):434\u0026ndash;440\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFabiani A, Dal Bo E, Di Bella S, Gabrielli M, Bologna A, Albert U, Sanson G (2021) Pica (Allotriophagy): An Underestimated Risk Factor for Severe Leptospirosis (Weil's Diseases)? Report of a Leptospira Septic Shock Successfully Managed with ECMO. Infect Dis Rep 13 (3):619\u0026ndash;626\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eMarquez A, Djelouadji Z, Lattard V, Kodjo A (2017) Overview of laboratory methods to diagnose Leptospirosis and to identify and to type leptospires. International microbiology: the official journal of the Spanish Society for Microbiology 20 (4):184\u0026ndash;193\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eAnonymous (2020) First NGS-based COVID-19 diagnostic. Nat Biotechnol 38 (7):777\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eWu H, Wei J, Yu D (2020) Application of NGS in Diagnosis of Tuberculous Pleurisy with Multiple Negative Tests: A Case Report. Infection and drug resistance 13:3543\u0026ndash;3550\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSimner P, Miller S, Carroll K (2018) Understanding the Promises and Hurdles of Metagenomic Next-Generation Sequencing as a Diagnostic Tool for Infectious Diseases. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 66 (5):778\u0026ndash;788\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eLu J, Hu J, Yu S, Li L (2021) Next Generation Sequencing for Diagnosis of Leptospirosis Combined With Multiple Organ Failure: A Case Report and Literature Review. Frontiers in medicine 8:756592\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSuputtamongkol Y, Pongtavornpinyo W, Lubell Y, Suttinont C, Hoontrakul S, Phimda K, Losuwanaluk K, Suwancharoen D, Silpasakorn S, Chierakul W, Day N (2010) Strategies for diagnosis and treatment of suspected leptospirosis: a cost-benefit analysis. PLoS Negl Trop Dis 4 (2):e610\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003e\u0026nbsp;Acknowledgements\u003c/strong\u003e\u0026nbsp; \u0026nbsp;This work was supported by the National Natural Science Foundation of China (82000018), the Fundamental Research Fund for the Central Universities (WK9110000089).\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor contribution\u003c/strong\u003e\u0026nbsp; \u0026nbsp;Xuqin Jiang and Xiaodong Mei designed the study. Hui Jiang, Yingying Xiong , Ming Fang and Bei Geng took responsibility for the integrity of data and accuracy of the data analysis. Xuqin Jiang wrote the draft of the paper. Xiaodong Mei and Huimei Wu revised and edited the paper. All authors contributed to writing or reviewing the paper.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData availability \u0026nbsp;\u0026nbsp;\u003c/strong\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCode availability \u0026nbsp;\u0026nbsp;\u003c/strong\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthics approval\u0026nbsp;\u003c/strong\u003e\u0026nbsp; The study was carried out in accordance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of The Affiliated First Hospital of USTC (Approval No: 2022-RE-067) .The demand for patient consent was waived due to the nature of a retrospective study.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent to participate\u003c/strong\u003e\u0026nbsp; \u0026nbsp;Written informed consent was obtained from all individuals involved in the study.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication \u0026nbsp;\u0026nbsp;\u003c/strong\u003eAll authors consent to publish.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflict of interest \u0026nbsp;\u0026nbsp;\u003c/strong\u003eThe authors declare no competing interests.\u003c/p\u003e"},{"header":"Tables","content":"\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;font-family:\"Times New Roman\",serif;'\u003eTable 1 Demographic features and clinical presentations of the patients\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 3.9e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:90.4pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:6.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:40.0pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:6.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;'\u003eCase1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:52.95pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:6.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;'\u003eCase2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:85.35pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:6.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;'\u003eCase3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.45pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:6.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;'\u003eCase4\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:46.45pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:6.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;'\u003eCase5\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:39.95pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.15pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:6.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;'\u003eCase6\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eGender\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eMale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eMale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eMale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eMale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eMale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eFemale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eDays from onset to admission\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eAge (yr)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e63\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e77\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e58\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e62\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e55\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;height: 21.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eUnderlying\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003c/span\u003e\u003cspan style=\"color:blue;text-decoration:underline;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003edisease\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003c/span\u003e\u003cspan style=\"color:blue;text-decoration:underline;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003es\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;height: 21.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"color:blue;text-decoration:underline;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style=\"color:windowtext;text-decoration:none;\"\u003eMalaria\u003c/span\u003e\u003c/a\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;height: 21.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;height: 21.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eHypertension\u003c/span\u003e\u003c/a\u003e\u003c/span\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e,\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eCerebral\u003c/span\u003e\u003c/a\u003e\u003c/span\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003einfarction\u003c/span\u003e\u003c/a\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;height: 21.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;height: 21.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;height: 21.85pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eConsciousness\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eAlert\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eLight coma\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eLight coma\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eAlert\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eAlert\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eComa\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eShock\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eFever\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eChest\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003c/span\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003edistress\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eDyspnea\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eHemoptysis\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style=\"font-size:15px;color:#2E75B5;\"\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eDiarrhea\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eConjunctival suffusion\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eMyalgia\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eArthralgia\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 90.4pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eJaundice\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 40pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.95pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85.35pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 33.45pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.45pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 39.95pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNo\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;line-height:11.0pt;'\u003e\u003cstrong\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;font-family:\"Times New Roman\",serif;'\u003eTable 2 Laboratory examinations of the patients\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.4e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:1.65in;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase4\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase5\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase6\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.5pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eRef. values\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBlood routine\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;White blood cell (\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L )\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e19.87\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e12.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e10.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e15.40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e14.44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e14.88\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e3.50 to 9.50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Neutrophil count(\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L )\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e17.50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e10.70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e9.10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e12.80\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e11.95\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e13.9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1.80 to 6.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Hemoglobin (g/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e108.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e66.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e120.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e75.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e117\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e107\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e130.0 to 175.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Platelets (\u0026times;10\u003csup\u003e9\u003c/sup\u003e/L )\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e34\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e33\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e120\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e24\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e125-350\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBiochemistry examinations\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;height: 9.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;ALT (U/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 9.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e23.3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 9.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e47.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 9.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e64.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 9.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e57.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 9.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e52.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 9.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e286.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;height: 9.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e5.0-50.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;AST (U/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e46.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e186.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e100.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e85.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e114.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e495.9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e15.0-45.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;GGT (U/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e41.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e30.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e35.9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e45.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e46.2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e10.0-60.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Albumin (g/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e35.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e24.2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e28.3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e25.6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e21.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e40.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e40.0-55.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;height: 0.15in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Creatinine (umol/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 0.15in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e164.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 0.15in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e230.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 0.15in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e134.1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 0.15in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e89.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 0.15in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e302.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 0.15in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e405.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;height: 0.15in;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e57.0-111.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Urea nitrogen (mmol/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e28.80\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e15.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7.90\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e9\u003c/span\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e.\u003c/span\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e10\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e19.60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e18.60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e3.10-8.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Total bilirubin (umol/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e21.6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e67.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e27.3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e17.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e44.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e14.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e3.4-21.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Direct bilirubin (umol/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e10.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e58.60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e17.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e10.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e32.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e9.60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.00-5.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eIndirect\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family: \"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003ebilirubin\u003c/span\u003e\u003c/strong\u003e\u003c/a\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;(umol/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e11.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e8.90\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e10.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e6.80\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.00-18.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;LDH (U/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1269\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e381\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e363\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e459\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e303\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2766.2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e120-250\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;CK U/L\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e136\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e3642\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1180\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e98\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e497\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e940\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e39-308\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;height: 7.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCoagulation parameters\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 7.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 7.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 7.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 7.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 7.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 7.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;height: 7.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Prothrombin time(seconds)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e11.60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e16.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e15.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e11.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e13.60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e12.60\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e8.00-14.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;APTT (seconds)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e20.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e54.50\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e39.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e43.90\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e33.8\u003c/span\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e35.70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e20.00-40.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;INR\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.99\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1.42\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.86\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1.17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1.08\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u0026gt; 1.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Troponin I (ug/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.096\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.130\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2.24\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.020\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026lt;0.05\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1.710\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.000-0.034\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eArterial blood gases analysis\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;PH\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7.495 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7.2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7.26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7.439\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7.05\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7.395\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7.35-7.45\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;PaO2 (mmHg)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e72.2 \u0026nbsp; \u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e45.9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e91.30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e58.1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e180\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e90.3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e70-100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;PaCO2 (mmHg)\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e36.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e41.6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e35.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e16.3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e27\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e33.2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e32-45\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;PaO2/FiO2 (mmHg)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e180.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e218.6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e130.4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e96.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e180.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e180.6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026gt;300\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eOthers\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;CRP (mg/L)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e210.46\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e216.26\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e256.78\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e135.86\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e242.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e165.7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.00 to 10.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;PCT (ng/ml)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e26.020\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e11.176\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026gt;100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.558\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e18.23\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026gt;100\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0.000-0.500\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;Urine erythrocyte (/ul)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e48.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2915.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e799.9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e296\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e182\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0-17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;NT-proBNP (pg/ml)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e4305\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e28727\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e5579\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1440\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e12179.9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e8490\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0-125,0-900.0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;CD3+CD4+%\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e22.9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e35.4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e23.8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e37.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e28.5-60.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;P-ANCA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 1.65in;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;C-ANCA\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.8pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:16px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;font-family:\"Times New Roman\",serif;'\u003eTable 3 Microbiological examination results of the patients\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.0e+2pt;margin-left:-15.25pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:95.15pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.85pt;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:67.65pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.85pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.15pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.85pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.85pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.5pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.85pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase4\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:42.55pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.85pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase5\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:19.85pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase6\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003emNGS \u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; Samples used\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBALF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBlood\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBlood\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBALF\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBlood\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBlood\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; Reads for leptospira\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e188233\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; Results judgment\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; Others reported\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eAspergillus\u003c/span\u003e\u003c/a\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eRoseomonas\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp; \u0026nbsp;Days\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003ebefore sampling\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border: medium none;padding: 0in 5.4pt;height: 9.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-top:0in;margin-right:0in;margin-bottom:7.8pt;margin-left:32.15pt;text-indent:-32.15pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp; \u0026nbsp; Days\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003ebefore diagnosis\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: medium none;padding: 0in 5.4pt;height: 9.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium none;padding: 0in 5.4pt;height: 9.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;height: 9.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 9.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 9.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;height: 9.75pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBlood PCR assay results\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border: medium none;padding: 0in 5.4pt;height: 7.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eSputum culture\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border: medium none;padding: 0in 5.4pt;height: 7.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border: medium none;padding: 0in 5.4pt;height: 7.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;height: 7.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border: medium none;padding: 0in 5.4pt;height: 7.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border: medium none;padding: 0in 5.4pt;height: 7.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;height: 7.5pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width: 112.8pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eBlood culture\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 50pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.15pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.5pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 42.55pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd style=\"border:none;\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:16px;font-family:\"Times New Roman\",serif;'\u003eTable 4 Treatment modulation base on mNGS results and outcome of the patients\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003ctable style=\"width: 4.2e+2pt;border-collapse:collapse;border:none;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:99.25pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase1\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase2\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase3\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase4\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:56.7pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase5\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;border-top:solid windowtext 1.5pt;border-left:none;border-bottom:solid windowtext 1.5pt;border-right:none;padding:0in 5.4pt 0in 5.4pt;height:20.0pt;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCase6\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: medium none;padding: 0in 5.4pt;height: 54.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eInitial antibiotics regime\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;height: 54.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCefoperazone\u003c/span\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;sulbactam\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;height: 54.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eImipenem-Cilastatin Sodium\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;height: 54.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eImipenem-Cilastatin Sodium\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;height: 54.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eMeropenem\u003c/span\u003e\u003c/a\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e,\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eVancomycin\u003c/span\u003e\u003c/a\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e,\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eAcyclovir\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;height: 54.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eMeropenem\u003c/span\u003e\u003c/a\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e,\u003c/span\u003e\u003c/p\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eMoxifloxacin\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border: medium none;padding: 0in 5.4pt;height: 54.95pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eMeropenem\u003c/span\u003e\u003c/a\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eModulation on mNGS\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eCeftriaxone\u003c/span\u003e\u003c/a\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e,\u0026nbsp;\u003c/span\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eVoriconazole\u003c/span\u003e\u003c/a\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eCeftriaxone\u003c/span\u003e\u003c/a\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eCeftriaxone\u003c/span\u003e\u003c/a\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eCeftriaxone\u003c/span\u003e\u003c/a\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e/\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003ca href=\"javascript%3A;\"\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;color:windowtext;text-decoration:none;'\u003eCeftriaxone\u003c/span\u003e\u003c/a\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eAdmitted to ICU\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: medium none;padding: 0in 5.4pt;height: 2.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eInvasive ventilation\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;height: 2.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;height: 2.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;height: 2.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;height: 2.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;height: 2.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border: medium none;padding: 0in 5.4pt;height: 2.65pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eYes\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eVentilation time (days)\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eDays of hospitalization\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e13\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e6\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border: medium none;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003e16\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 99.25pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cstrong\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eOutcomes\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCured\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCured\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCured\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCured\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.7pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eDied\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;border-color: currentcolor currentcolor windowtext;border-style: none none solid;border-width: medium medium 1.5pt;border-image: none 100% / 1 / 0 stretch;padding: 0in 5.4pt;vertical-align: top;\"\u003e\n \u003cp style='margin:0in;text-align:center;font-size:14px;font-family:\"Calibri\",sans-serif;margin-bottom:7.8pt;'\u003e\u003cspan style='font-size:11px;font-family:\"Times New Roman\",serif;'\u003eCured\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style='margin:0in;text-align:justify;font-size:14px;font-family:\"Calibri\",sans-serif;'\u003e\u003cspan style='font-family:\"Times New Roman\",serif;'\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[{"identity":"6d9c7f69-a8e9-44d4-b785-9af1f9708f2e","identifier":"10.13039/501100001809","name":"National Natural Science Foundation of China","awardNumber":"82000018","order_by":0}],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"The first Affiliated Hospital of UStC,Division of Life Sciences and Medicine,University of Science and Technology of China","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Metagenomics next generation sequencing, Leptospirosis, Diagnosis, Prognosis, Treatment","lastPublishedDoi":"10.21203/rs.3.rs-2108428/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-2108428/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003ePurposes\u003c/strong\u003eTo evaluate the diagnostic efficiency of metagenomics next generation sequencing (mNGS) assay in severe leptospirosis and its role on prognosis.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e We retrospectively reviewed the medical records of patients with confirmed leptospirosis from Jan. 1, 2019 to Dec. 31, 2021 from three hospitals. Detailed data including socio-demographic data, clinical manifestations, laboratory examination results, CT images etc. were collected and analyzed.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults \u003c/strong\u003eSix severe cases were included in this study. All were diagnosed by positive mNGS results. Three of the patients were also polymerase chain reaction examined and presented negative results. Five patients were diagnosed by mNGS assay within two or three days and antibiotics were down-graded to ceftriaxone in them. All of them were cured finally. One case, who was diagnosed by mNGS late on day 5, died.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions \u003c/strong\u003emNGS is highly efficient in diagnosing leptospirosis and could possibly reduce the mortality rate if used at an early stage.\u003c/p\u003e","manuscriptTitle":"Early diagnosis by mNGS could improve the prognosis for severe leptospirosis patients","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2022-09-30 17:51:34","doi":"10.21203/rs.3.rs-2108428/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"91963460-d62b-4566-9660-ecc1ea97b4e7","owner":[],"postedDate":"September 30th, 2022","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":15866585,"name":"General Microbiology"}],"tags":[],"updatedAt":"2022-09-30T17:51:34+00:00","versionOfRecord":[],"versionCreatedAt":"2022-09-30 17:51:34","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-2108428","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-2108428","identity":"rs-2108428","version":["v1"]},"buildId":"rHA-KDH7Qsr4HCuvH75dn","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}