Unified Field Theory of Genomic Dynamics: Data-Driven Reconstruction and Experimental Validation

Unified Field Theory of Genomic Dynamics: Data-Driven Reconstruction and Experimental Validation | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 17 September 2025 V1 Latest version Share on Unified Field Theory of Genomic Dynamics: Data-Driven Reconstruction and Experimental Validation Authors : Dongqi Liu and shifa liu 0009-0003-6570-2812 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.175812568.81172225/v1 281 views 130 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract 我们提出了一个基因组动力学的统一场论，该理论是根据 38 个涵盖量子到进化尺度的公共数据集重建的。该理论整合了三个基本定律：（1）量子退相干定律，f （t） = λe −Γt [1 + κ cos（ωqt）]，以0.7%的平均绝对误差（MAE）进行验证;（2）空间交互定律，⟨r −2 ⟩ eff = （2ξ 2） −1 ，MAE为0.3%;（3）自由能原理，∆G（T） = Ea（T −1 − T −1 0） + α（1 − T /Tc），与经典的伊辛和聚合物模型相比，参数降低了67%。实验验证表明，小鼠模型中的CRISPR-Cas9编辑效率为76.3%（p < 10 −5）和83%的肿瘤消退。统一算子 F（t， r， T） 整合了 32 个时间量级的动力学，总体 MAE 为 0.15%。这项工作为基因组学的跨尺度理解提供了基础框架。 Supplementary Material File (gen (1).pdf) Download 368.02 KB Information & Authors Information Version history V1 Version 1 17 September 2025 Copyright This work is licensed under a Creative Commons Attribution 4.0 International License Keywords chromatin interactions free energy landscape genomic dynamics multi-scale modeling quantum decoherence unified field theory Authors Affiliations Dongqi Liu The University of North Carolina at Chapel Hill Chapel Hill shifa liu Peking University View all articles by this author shifa liu 0009-0003-6570-2812 [email protected] View all articles by this author Metrics & Citations Metrics Article Usage 281 views 130 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Dongqi Liu, shifa liu. 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