�븳援� �뿬�꽦�뿉�꽌 以묒쬆 �옄沅곷궡留됱쬆怨� Human 慣2-Heremans Schmidt (HS) Glycoprotein (AHSG) �쑀�쟾�옄 �떎�삎�꽦�쓽 �뿰愿��꽦

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2015 · W7035199178
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This study investigated the association between advanced stage endometriosis and AHSG gene polymorphisms in Korean women and found no significant differences in genotype or haplotype frequencies.

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This study evaluated whether polymorphisms in the α2-Heremans Schmidt glycoprotein (AHSG) gene are associated with advanced-stage endometriosis in Korean women. One hundred thirty women with endometriosis stage III/IV and 224 women without endometriosis were genotyped using PCR and RFLP analysis. AHSG genotype distributions and the frequency of the AHSG 2 haplotype did not differ significantly between cases and controls, and the authors concluded that AHSG polymorphism was not associated with risk of advanced-stage endometriosis in this population; a key limitation is that the analysis focused on stage III/IV rather than all disease stages. This paper is centrally about endometriosis — it tests the association between advanced-stage endometriosis and AHSG gene polymorphisms in Korean women.

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Abstract

Objective: To evaluate the relationship between advanced stage endometriosis and polymorphisms in 慣2-Heremans Schmidt glycoprotein (AHSG) gene in Korean women. Methods: One-hundred thirty women with endometriosis stage III and IV, and 224 women without endometriosis were enrolled. In these patients, we determined AHSG gene polymorphisms by PCR and RFLP (restriction fragment length polymorphism) analysis. Results: The genotype distribution of the AHSG gene polymorphism in the endometriosis group was not different from that of the control group (AHSG 1*1/AHSG 1*2/AHSG 2*2 frequencies were 56.2%/37.7%/6.2% and 55.8%/39.3%/4.9% for the endometriosis and control groups, respectively, p=.864). Also, the frequency of AHSG 2 haplotype was not different between endometriosis patients and controls (AHSG 1 haplotype /AHSG 2 haplotype rates were 75.0%/25.0% and 75.4%/24.6% for the endometriosis and control groups, respectively, p=0.894). Conclusion: AHSG gene polymorphism was not associated with the risk of advanced stage endometriosis in the Korean population
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YUHASpace Repository 65 856 Cited 0 times in Cited 0 times in 한국 여성에서 중증 자궁내막증과 Human α2-Heremans Schmidt (HS) Glycoprotein (AHSG) 유전자 다형성의 연관성 - Other Titles - Association between Endometriosis and Human α2-Heremans Schmidt Glycoprotein (AHSG) Polymorphism - Authors - 김진주 ; 채수진 ; 김종미 ; 이경훈 ; 최영민 ; 김성훈 ; 신정호 ; 이택후 ; 허준용 ; 이병석 ; 오성택 ; 이규섭 ; 임용택 - Citation - Korean Journal of Reproductive Medicine (대한생식의학회지), Vol.35(4) : 264-274, 2008 - Journal Title - Korean Journal of Reproductive Medicine(대한생식의학회지) - ISSN - 1226-2951 - Issue Date - 2008 - Abstract - Objective: To evaluate the relationship between advanced stage endometriosis and polymorphisms in α2-Heremans Schmidt glycoprotein (AHSG) gene in Korean women. Methods: One-hundred thirty women with endometriosis stage III and IV, and 224 women without endometriosis were enrolled. In these patients, we determined AHSG gene polymorphisms by PCR and RFLP (restriction fragment length polymorphism) analysis. Results: The genotype distribution of the AHSG gene polymorphism in the endometriosis group was not different from that of the control group (AHSG 1*1/AHSG 1*2/AHSG 2*2 frequencies were 56.2%/37.7%/6.2% and 55.8%/39.3%/4.9% for the endometriosis and control groups, respectively, p=.864). Also, the frequency of AHSG 2 haplotype was not different between endometriosis patients and controls (AHSG 1 haplotype /AHSG 2 haplotype rates were 75.0%/25.0% and 75.4%/24.6% for the endometriosis and control groups, respectively, p=0.894). Conclusion: AHSG gene polymorphism was not associated with the risk of advanced stage endometriosis in the Korean population - Files in This Item: - T200895897.pdf Download - Appears in Collections: - 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers - Yonsei Authors - Lee, Byung Seok(이병석) https://orcid.org/0000-0001-6001-2079 Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

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