Metabolomics for the Identification of Biomarkers in Rheumatoid Arthritis.

Swarnima Pandey
Phenomics (Cham, Switzerland) · 2025 · doi:10.1007/s43657-025-00242-9 · PMID:40895320 · PMC12390890
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⚙ AI-generated summary by qwen3.7-flash, 2026-09-10 ⓘ

This paper utilizes metabolomics to identify biomarkers specifically for rheumatoid arthritis, without establishing a connection to endometriosis or adenomyosis.

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This review article examines the utility of metabolomics in identifying biomarkers for rheumatoid arthritis, focusing on metabolic disruptions in amino acids and lipids that reflect disease progression and drug response. The authors highlight that current serological markers like ACPA and RF lack specificity, leading to diagnostic challenges, particularly in seronegative patients. They discuss how techniques such as NMR and mass spectrometry can detect distinct metabolic profiles associated with inflammation and treatment efficacy from agents like methotrexate and Janus kinase inhibitors. Relevance to endometriosis: listed as one indication for metabolomic studies alongside other conditions, though the paper's main focus is rheumatoid arthritis.

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Acknowledgements

N/A. Author Contributions Pandey conceptualized, drafted, and reviewed the manuscript. Funding N/A. Data Availability N/A. Declarations Ethics Approval and Consent to Participate N/A. Consent for Publication Yes. Competing Interests There are no competing interest.

References

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