<!-- Brazil - Googling adenomyosis: a systematic review of internet-based information Googling adenomyosis: a systematic review of internet-based information window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-MKLVK7B5B6'); .articleTxt{ top: -16px; } .scielo__border-top{ border-top: 1px solid #ccc !important; } @media (max-width: 575.98px) { .articleCtt > .container{ padding-left: 0; padding-right: 0; } .articleCtt .articleTxt{ padding-left: 16px !important; padding-right: 16px !important; } } @media (min-width: 768px){ .scielo__truncate{ display: block; max-width: 285px; } } menu Menu Brazil Journal list by title Journal list by subject area Search Metrics (abre em nova aba) Sobre o SciELO Brazil Contacts Report error SciELO.org - The SciELO Network (abre em nova aba) National and thematic collections (abre em nova aba) Journal list by title (abre em nova aba) Journal list by subject (abre em nova aba) Search (abre em nova aba) Metrics (abre em nova aba) OAI and RSS (abre em nova aba) About the SciELO Network (abre em nova aba) Contacts (abre em nova aba) Blog SciELO in Perspective (abre em nova aba) document.addEventListener('DOMContentLoaded', function () { const wrapper = document.getElementById('scieloMainMenu'); const toggle = document.getElementById('scieloMainMenuToggle'); const panel = document.getElementById('scieloMainMenuNav2'); if (!wrapper || !toggle || !panel) return; const icon = toggle.querySelector('.material-icons-outlined'); const focusableSelector = [ 'a[href]', 'button:not([disabled])', 'input:not([disabled])', 'select:not([disabled])', 'textarea:not([disabled])', '[tabindex]:not([tabindex="-1"])' ].join(','); function setIcon(iconName) { if (icon) { icon.textContent = iconName; } } function getFocusableItems() { return Array.prototype.slice.call(panel.querySelectorAll(focusableSelector)) .filter(function (item) { return item.offsetParent !== null; }); } function openMenu() { panel.hidden = false; toggle.setAttribute('aria-expanded', 'true'); wrapper.classList.add('is-open'); setIcon('close'); const focusableItems = getFocusableItems(); if (focusableItems.length) { focusableItems[0].focus(); } } function closeMenu(options) { const settings = options || {}; panel.hidden = true; toggle.setAttribute('aria-expanded', 'false'); wrapper.classList.remove('is-open'); setIcon('menu'); if (settings.restoreFocus) { toggle.focus(); } } function isMenuOpen() { return toggle.getAttribute('aria-expanded') === 'true'; } toggle.addEventListener('click', function (event) { event.preventDefault(); event.stopPropagation(); if (isMenuOpen()) { closeMenu({ restoreFocus: true }); } else { openMenu(); } }); panel.addEventListener('click', function (event) { event.stopPropagation(); }); document.addEventListener('click', function (event) { if (isMenuOpen() && !wrapper.contains(event.target)) { closeMenu(); } }); document.addEventListener('keydown', function (event) { if (!isMenuOpen()) return; if (event.key === 'Escape') { event.preventDefault(); closeMenu({ restoreFocus: true }); return; } if (event.key !== 'Tab') return; const focusableItems = getFocusableItems(); if (!focusableItems.length) return; const firstItem = focusableItems[0]; const lastItem = focusableItems[focusableItems.length - 1]; if (event.shiftKey && document.activeElement === firstItem) { event.preventDefault(); toggle.focus(); return; } if (!event.shiftKey && document.activeElement === toggle) { event.preventDefault(); firstItem.focus(); return; } if (!event.shiftKey && document.activeElement === lastItem) { closeMenu(); } }); }); Brazil language en English Português Español Revista da Associação Médica Brasileira Mostrar opções launch Submission of manuscripts info About the journal help_outline Política editorial people Editorial Board help_outline Instructions to authors email Contact show_chart Metrics home Table of contents navigate_before previous current next navigate_next (indisponível) Text (EN) Text (English) PDF Download PDF (English) article Conteúdo: Text (EN) Text (English) Download PDF (English) (abre em nova aba) share Whatsapp BlueSky Mastodon Facebook Mais home Table of contents share Whatsapp BlueSky Mastodon Facebook Mais Text (EN) Text (English) PDF Download PDF (English) (abre em nova aba) REVIEW ARTICLE • Rev. Assoc. Med. Bras. 72 (4) • 2026 • https://doi.org/10.1590/1806-9282.20251982 link copy Googling adenomyosis: a systematic review of internet-based information Authorship SCIMAGO INSTITUTIONS RANKINGS INTRODUCTION Adenomyosis is characterized by the presence of endometrial tissue in the myometrium, associated with hypertrophy and hyperplasia in the adjacent myometrial tissue 1 . With an estimated prevalence of 20–34%, adenomyosis is the most common uterine disorder in women of reproductive age worldwide and is known to be a contributing factor to dysmenorrhea, pelvic pain, heavy menstrual bleeding, and subfertility 2 . Globalization and the advent of the internet have granted widespread access to a vast array of content and information. This content encompasses multiple areas of knowledge, including health-related topics. Today, the internet has become a significant source of research for a large number of women seeking immediate clarification regarding their medical conditions 3 , 4 . However, a crucial question arises: is this information truly reliable? It is essential that health consumers have access to high-quality, evidence-based information. In the healthcare context, lay texts discussing symptoms, treatments, and prognoses may inadvertently cause emotional distress and negatively affect the doctor–patient relationship 3 . The lack of clarity in such texts may foster distrust among women, leading them to question the medical diagnosis, proposed management, and treatment options 4 , 5 , 6 , 7 . Poorly written lay texts that present adenomyosis treatments in a generalized and confusing manner can induce insecurity and anxiety in patients. Furthermore, women may be induced to initiate self-treatment without medical guidance, resulting in ineffective care, false expectations, and unnecessary financial burden 4 , 5 , 6 , 7 . Given this context, the present study aims to evaluate the quality and accuracy of online medical information regarding the characteristics of adenomyosis. METHODS A protocol was registered in the International Prospective Register of Systematic Reviews, number: CRD42023395332. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement 8 . Selection of publications A systematic review was conducted of publications related to the term “Adenomyosis,” in both English and Portuguese, on World Wide Web websites during the period from January 1, 2023, to March 31, 2023, using a lay literature search platform (Google). Exclusion criteria The following were excluded from analysis: duplicate texts, scientific or medical literature, advertisements, content from social media, unavailable or paid-access pages, exam-related questions, news articles, texts in other languages, repeated entries, and personal narratives, such as case reports. Classification of publications Two reviewers (BPA and CLSA) were trained in the use of quality assessment tools. Accuracy was assessed based on a prioritized list of recommendations included in the Brazilian Federation of Gynecology and Obstetrics guidelines. All recommendations were extracted by two authors independently. Discrepancies were resolved by discussion. The lay literature texts were evaluated based on six key domains related to adenomyosis: definition, risk factors, signs and symptoms, diagnosis, clinical treatment, and surgical treatment. These domains were cross-referenced with current clinical guidelines ( Table 1 ). Notably, two reviewers independently reviewed each website, assessing the accuracy of the information. Each domain was scored as follows: 0 (absent or incorrect), 1 (incomplete), or 2 (complete). Accuracy assessment was anchored between 0 and 12. Discrepancies were resolved by discussion. Thumbnail Table 1 Key domains in adenomyosis. Notably, two reviewers independently assessed each website using validated instruments, including assessments of credibility assessed by the White instrument, with a score between 0 (poor) and 10 (excellent); quality assessed by the DISCERN instrument; and readability assessed by the Flesch-Kincaid instrument, with a score between 0 (poor) and 100 (excellent). Discrepancies were resolved by a third reviewer (DAY). The credibility of the websites was assessed by two reviewers independently using the validated instrument. This instrument, developed for consumers of health information, provides a set of criteria that can be used to accurately and reliably assess the quality of health information on the internet. Credibility was assessed using 10-point criteria: (1) source; (2) context; (3) currency; (4) usefulness; (5) editorial review process; (6) hierarchy of evidence; (7) statement of original source; (8) disclaimer, which included ownership, sponsorship, funding, and advertising; (9) omissions; and (10) feedback 9 . Following the comparison, the quality level of each text was assessed using the DISCERN tool, which provides a score from 1 to 5 across 16 questions that evaluate the quality of health information provided. Based on DISCERN’s guidelines 10 , 11 , publications were classified as: High (scores 4 and 5): indicates the publication is of “good” quality—a useful and appropriate source of information regarding treatment options; Moderate (score 3): indicates the publication is of “fair” quality—a generally useful source of information but with notable limitations; additional information or support would clearly be required; and Low (scores 1 and 2): indicates the publication is of “poor” quality—contains serious shortcomings and is neither useful nor appropriate as a source of treatment-related information; unlikely to provide any benefit and should not be used. Websites’ readability was assessed using the Flesch-Kincaid Reading Ease Test 12 . The Flesch-Kincaid score is generated from the following equation: 206.835 and 1.015 (total words/total sentences) and 84.6 (total syllables/total words) ( www.readabilityscore.com ). The scores were anchored between 0 (complex language) and 100 (simple language) and could be categorized by reading age or educational status: 90–100 (5th grade); 80–90 (6th grade); 70–80 (7th grade); 60–70 (8th and 9th grade); 50–60 (10th, 11th, and 12th grade); 30–50 (college); or 0–30 (college graduate). Discrepancies were resolved through discussion among reviewers. RESULTS In the Portuguese language, 249 websites were analyzed, of which 216 were excluded by the initial reviewers. Of the remaining websites, 14 had disagreements and were excluded by a third reviewer. In total, 230 websites were excluded. The reasons for exclusion, in order of frequency, are listed below. In the English language, 202 websites were analyzed, of which 161 were excluded by the initial reviewers. Of the remaining websites, 9 had disagreements and were excluded by a third reviewer. In total, 170 websites were excluded. The reasons for exclusion, in order of frequency, are listed in Figure 1 . Figure 1 Flowchart of the selection of websites in the Portuguese and English language. Of the 19 included websites, 12 sites (63.16%) received a score of 1 on DISCERN (low quality), 6 sites (31.58%) received a score of 3 (moderate quality), and only 1 site (5.26%) received a score of 5 (high quality). As for readability, all sites required a higher education level, with 12 sites requiring ongoing college and 7 sites requiring college graduates. Only 6 out of 19 sites (31.6%) were considered accurate, while the other 13 were not accurate. Among the sites considered accurate (score of 8 or higher), 3 sites received a score of 10 (out of 12), 1 site scored 9, and 2 sites scored 8. Among the sites considered not accurate, 4 sites received a score of 7, 5 sites scored 6, 1 site scored 5, 1 site scored 4, and 2 sites scored 2. The average accuracy score of the sites in Portuguese was 6.631. Of the 19 sites, only 2 were considered credible, with 1 site scoring 8 (out of 10) and 1 site scoring 7. The remaining 17 sites were considered not credible: 3 sites scored 6, 2 sites scored 5, 9 sites scored 4, 2 sites scored 3, and 1 site scored 2. The average credibility score of the sites in Portuguese was 4.578. All Portuguese-language websites included a definition of adenomyosis and the symptoms. The risk factors were described in 16 of them. Diagnosis was mentioned on 16 websites. Regarding treatment, medical management was described on all websites, while surgical treatment was mentioned in 18. While in Portuguese the main reason for exclusion was “social media,” in English it was “medical literature.” Of the 32 included websites, 18 sites (56.25%) received a score of 1 on DISCERN (low quality), 10 sites (31.25%) received a score of 3 (moderate quality), and 4 sites (12.5%) received a score of 5 (high quality) ( Table 2 ). As for readability, all sites required a higher education level, with 10 sites requiring ongoing college and 22 sites requiring college graduates. Thumbnail Table 2 Included websites in Portuguese and English language - DISCERN score. Of the 32 sites, only 10 were considered accurate (31.25%), while the other 22 were not accurate. Among the sites considered accurate (score of 8 or higher), 1 site received a score of 11 (out of 12), 3 sites scored 10, 4 sites scored 9, and 2 sites scored 8. Among the sites considered not accurate, 8 sites received a score of 7, 4 sites scored 6, 9 sites scored 5, and 1 site scored 3. The average accuracy score of the sites in English was 6.9, which was higher than the average of the sites in Portuguese. Of the 32 sites, only 2 were considered credible, both scoring 9 (out of 10). The remaining 30 sites were considered not credible: 5 sites scored 6, 3 sites scored 5, 9 sites scored 4, 6 sites scored 3, 4 sites scored 2, 2 sites scored 1, and 1 site scored 0. The average credibility score of the sites in English was 3.968, which was lower than the average of the sites in Portuguese. All English-language websites included a definition of endometriosis. The risk factors were described on 29 websites. Regarding symptoms, all websites provided a description, and diagnosis was addressed on 26 websites. Medical treatment was described on 28 websites, while surgical treatment was mentioned on 25. A total of 451 sites were analyzed, considering the sites in English and Portuguese, with 51 included and 400 excluded, mainly due to social media. The average credibility score was 4.196, with 47 sites lacking credibility (92.15%). All included sites were rated as very difficult or difficult to read, requiring higher education (22 sites required ongoing college, 29 sites required a college graduate). Only 5 sites were deemed of good quality according to DISCERN. Of these, 30 sites received a score of 1, 16 sites received a score of 3, and 5 sites received a score of 5. The average accuracy was 6.803, with 16 sites considered accurate and 35 not. DISCUSSION The search for online information is often a first step for patients seeking clarification of their symptoms, particularly in resource-limited places or where access to specialist care is delayed. When the available information is inaccurate or lacking in scientific rigor, it not only delays diagnosis and treatment but may also foster anxiety, lead to harmful self-management practices, and impair trust in healthcare professionals 4 , 6 . In the Portuguese websites, the main reason for exclusion was social media content, suggesting a possible prevalence of social media as a primary platform for discussing medical conditions. In contrast, most of the excluded English websites were categorized as medical literature, which may hinder comprehension and even lead to readers abandoning the content altogether. This study evaluated the quality, credibility, and accuracy of online lay literature on adenomyosis, revealing an alarming prevalence of low-quality information. Out of 451 analyzed websites, only 5 (1.1%) were rated as high-quality according to the DISCERN instrument, while the vast majority (92.1%) lacked credibility. These findings align with prior research on other gynecological conditions, which consistently highlights the widespread presence of misleading or incomplete health content on the internet 5 , 7 . The results of this study are consistent with the existing literature. A meta-analysis of 153 studies evaluating the quality of 11,785 health-related websites aimed at the general public found that none of the sources were rated as “excellent” according to the DISCERN criteria. Between 37 and 79% were considered to be of good quality, while the remainder were classified as poor 13 . In that study, websites were categorized by medical specialty, and in addition to DISCERN, the HONcode—a code of ethics developed to guide site managers in providing high-quality, objective, and transparent medical information online—was also used to assess website quality. Among the evaluated websites, those related to oncology and internal medicine had the highest rate of HONcode certification (30%), whereas gynecology and obstetrics had the lowest (11%). This is particularly concerning, as it suggests that conditions such as adenomyosis, along with other gynecological disorders, are being inadequately addressed on the internet, potentially undermining women’s healthcare. Another cross-sectional literature review of published studies on online health information, which examined trends in the use of health-related websites, concluded that the individuals most likely to seek health information online were women, younger people, students, and working professionals 14 . This highlights how women, in particular, may be especially vulnerable in this context. The quality of online health information requires significant improvement—an issue that should be prioritized by policymakers as well as public and private institutions. Moreover, the readability analysis indicated that most texts required a high level of formal education, further limiting accessibility. A systematic review investigating differences in how people with varying levels of health literacy evaluate online information found that low health literacy, education level, and related skills are negatively associated with both the ability to critically assess and the trust placed in online health information 15 . These barriers affect mainly vulnerable populations and contradict recommendations from international institutions advocating for inclusive, patient-centered communication in women’s health 16 . CONCLUSION The majority of sites found in English and Portuguese on Google are unreliable sources regarding adenomyosis, often classified as “low quality,” primarily failing to address treatment comprehensively. DATA AVAILABILITY STATEMENT The datasets generated and/or analyzed during the current study are available from the corresponding author upon reasonable request. REFERENCES 1. Andres MP, Borrelli GM, Ribeiro J, Baracat EC, Abrão MS, Kho RM. Transvaginal ultrasound for the diagnosis of adenomyosis: systematic review and meta-analysis. J Minim Invasive Gynecol. 2018;25(2):257-64. https://doi.org/10.1016/j.jmig.2017.08.653 » https://doi.org/10.1016/j.jmig.2017.08.653 2. Kho KA, Chen JS, Halvorson LM. Diagnosis, evaluation, and treatment of adenomyosis. JAMA. 2021;326(2):177-8. https://doi.org/10.1001/jama.2020.26436 » https://doi.org/10.1001/jama.2020.26436 3. Rosa CAP, Picarelli C, Ortona C. Relação médico-paciente: um encontro. São Paulo: Conselho Regional de Medicina do Estado de São Paulo; 2017. 4. Crocco AG, Villasis-Keever M, Jadad AR. Analysis of cases of harm associated with use of health information on the internet. JAMA. 2002;287(21):2869-71. https://doi.org/10.1001/jama.287.21.2869 » https://doi.org/10.1001/jama.287.21.2869 5. Swire-Thompson B, Lazer D. Public health and online misinformation: challenges and recommendations. Annu Rev Public Health. 2020;41:433-51. https://doi.org/10.1146/annurev-publhealth-040119-094127 » https://doi.org/10.1146/annurev-publhealth-040119-094127 6. Fergus TA, Dolan SL. Problematic internet use and internet searches for medical information: the role of health anxiety. Cyberpsychol Behav Soc Netw. 2014;17(12):761-5. https://doi.org/10.1089/cyber.2014.0169 » https://doi.org/10.1089/cyber.2014.0169 7. Hirsch M, Aggarwal S, Barker C, Davis CJ, Duffy JMN. Googling endometriosis: a systematic review of information available on the Internet. Am J Obstet Gynecol. 2017;216(5):451-8.e1. https://doi.org/10.1016/j.ajog.2016.11.1007 » https://doi.org/10.1016/j.ajog.2016.11.1007 8. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and metaanalyses: the PRISMA statement. BMJ. 2009;339:b2535. https://doi.org/10.1136/bmj.b2535 » https://doi.org/10.1136/bmj.b2535 9. Ambre J, Guard R, Perveiler FM, Renner J, Rippen H. Criteria for assessing the quality of health information on the Internet. 1997. [cited on 2023 Feb]. Available from: http://hitiWeb.mitretek.org/docs/criteria.html » http://hitiWeb.mitretek.org/docs/criteria.html 10. Charnock D. The DISCERN handbook. Oxford: Radcliffe Medical Press; 1998. 11. Charnock D, Shepperd S. Aprendendo a DISCERNIR online: aplicação de uma ferramenta de avaliação a sítios Web de saúde num ambiente de workshop. Pesquisa Educação Saúde. 2004;19:440-6. 12. Kincaid JP, Fishburne RP Jr, Rogers RL, Chissom BS. Derivation of new readability formulas (Automated Readability Index, Fog Count and Flesch Reading Ease Formula) for Navy enlisted personnel. Memphis (TN): Naval Air Station; 1975. 13. Daraz L, Morrow AS, Ponce OJ, Beuschel B, Farah MH, Katabi A, et al. Can patients trust online health information? A meta-narrative systematic review addressing the quality of health information on the internet. J Gen Intern Med. 2019;34(9):1884-91. https://doi.org/10.1007/s11606-019-05109-0 » https://doi.org/10.1007/s11606-019-05109-0 14. Battineni G, Baldoni S, Chintalapudi N, Sagaro GG, Pallotta G, Nittari G, et al. Factors affecting the quality and reliability of online health information. Digit Health. 2020;6:2055207620948996. https://doi.org/10.1177/2055207620948996 » https://doi.org/10.1177/2055207620948996 15. Diviani N, Putte B, Giani S, Weert JC. Low health literacy and evaluation of online health information: a systematic review of the literature. J Med Internet Res. 2015;17(5):e112. https://doi.org/10.2196/jmir.4018 » https://doi.org/10.2196/jmir.4018 16. World Health Organization (WHO). WHO guideline: recommendations on digital interventions for health system strengthening. Geneva: World Health Organization; 2019. Funding: None. Edited by Scientifıc Editor: Roseli Nomura https://orcid.org/0000-0002-6471-2125 Publication Dates Publication in this collection 15 June 2026 Date of issue 2026 History Received 05 Oct 2025 Accepted 06 Jan 2026 This is an article published in open access under a Creative Commons license. Authorship .author-card { border-bottom: 1px solid #ccc; padding: 1rem 0; } .author-card:last-child { border-bottom: 0px; } .author-name { font-weight: 600; } .orcid-button { padding-left: 2.5rem; } .modal-body { padding-bottom: 3rem; } .orcid-button::before { content: ""; position: absolute; background-image: url(https://ds.scielo.org/img/logo-orcid.svg); background-repeat: no-repeat; background-size: 1.5em auto; background-position: .5em center; display: block; width: 60px; height: 60px; top: -10px; left: 0; } person Beatriz Piaulino de Araújo Data curation · Formal Analysis · Writing – original draft school Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. Universidade de Campinas Brazil Campinas, SP, Brazil Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. 0009-0007-2393-5609 person Clarissa Suzart Lopes da Silva Data curation · Formal Analysis · Writing – original draft school Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. Universidade de Campinas Brazil Campinas, SP, Brazil Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. 0009-0003-1871-6533 person Cristina Laguna Benetti-Pinto Writing – review & editing school Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. Universidade de Campinas Brazil Campinas, SP, Brazil Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. 0000-0001-6198-5593 person Daniela Angerame Yela * Conceptualization · Supervision · Writing – review & editing school Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. Universidade de Campinas Brazil Campinas, SP, Brazil Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. 0000-0003-3889-4778 person *Corresponding author: email
[email protected] Conflicts of interest: the authors declare there is no conflicts of interest. Scientifıc Editor: Roseli Nomura https://orcid.org/0000-0002-6471-2125 SCIMAGO INSTITUTIONS RANKINGS Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. Universidade de Campinas Brazil Campinas, SP, Brazil Universidade de Campinas, School of Medical Sciences, Department of Obstetrics and Gynecology – Campinas (SP), Brazil. Figures | Tables Figures (1) Tables (2) Thumbnail Figure 1 Flowchart of the selection of websites in the Portuguese and English language. Thumbnail Table 1 Key domains in adenomyosis. Thumbnail Table 2 Included websites in Portuguese and English language - DISCERN score. image Figure 1 Flowchart of the selection of websites in the Portuguese and English language. open_in_new table_chart Table 1 Key domains in adenomyosis. Definition A gynecological condition characterized by the infiltration of endometrial tissue into the myometrium, leading to an increase in uterine volume. These infiltrations may present in a diffuse or nodular pattern, the latter forming what are known as adenomyomas. Risk factors Age between 40 and 50 years; Prolonged estrogen exposure: early menarche (≤10 years), short menstrual cycles (≤24 days); use of combined oral contraceptives; body mass index (BMI) ≥25; parity ≥2 deliveries; use of tamoxifen; and history of uterine surgeries (e.g., cesarean section, curettage). Clinical presentation Abnormal uterine bleeding, dysmenorrhea, chronic pelvic pain, dyspareunia, infertility. Some women may remain asymptomatic. Diagnosis Clinical signs: enlarged and softened uterus on physical examination. Gold standard: histopathological evaluation, typically performed via hysterectomy specimen or biopsy obtained through hysteroscopy or laparoscopy. Adenomyosis is confirmed when endometrial tissue is observed within the myometrium at a minimum depth of 1–4 mm from the endometrial-myometrial junction, or when at least 25–33% of the myometrial thickness is involved. Imaging findings: In 2D TVUS, heterogeneous myometrial echotexture is noted, with poorly defined foci that generate echogenic striations on ultrasound, myometrial cysts, globular uterus, asymmetry between the anterior and posterior walls, and poor definition of the myometrial-endometrial junction. In 3D TVUS, enlargement or hyperplasia of the junctional zone is observed, which is an important finding for the early diagnosis of adenomyosis. In MRI, the most common findings are an enlarged and asymmetric uterus, abnormal myometrial signal intensity, thickening of the junctional zone, and T1 hyperintense foci indicating hemorrhage, and T2 hypointense areas indicating junctional zone thickening. Pharmacological treatment Nonsteroidal anti-inflammatory drugs (NSAIDs), continuous use of combined oral contraceptives or progestin-only therapies, levonorgestrel-releasing intrauterine device (IUD), gonadotropin-releasing hormone (GnRH) agonists (short-term use, up to 6 months, due to hypoestrogenic side effects), aromatase inhibitors, and danazol. Surgical treatment Specific information on: Hysteroscopic endometrial ablation and resection. Uterine artery embolization (devascularization of adenomyotic areas of the myometrium leads to symptom improvement). Myometrial electrocoagulation via laparoscopy or hysteroscopy (promotes reduction of adenomyotic foci through necrosis. Its advantage is that it can be used both in localized and disseminated disease). Ultrasound-guided MRI (ExAblate). HTA—definitive treatment: hysterectomy is the first option for patients who have completed their reproductive cycle and present with severe symptoms. Uterine removal can be performed via vaginal, laparoscopic, or abdominal approach. table_chart Table 2 Included websites in Portuguese and English language - DISCERN score. Portuguese websites Score English websites Score https://www.procriar.com.br/blogprocriar/adenomiose-o-que-e-qual-tratamento/ 1 https://www.uabmedicine.org/specialties/adenomyosis/# 1 https://educa.cetrus.com.br/adenomiose-o-diferencial-do-us-no-diagnostico/#:~:text=A%20 adenomiose%20%C3%A9%20uma%20 modifica%C3%A7%C3%A3o,endometriais%20 envoltos%20por%20hiperplasia%20e 1 https://www.shreeivfclinic.com/blogs/stages-of-adenomyosis/ 1 https://drlucassantana.com/adenomiose/ 1 https://sonacare.com.au/adenomyosis 1 https://www.msdmanuals.com/pt-br/profissional/ginecologia-e-obstetr%C3%ADcia/doen%C3%A7as-ginecol%C3%B3gicas-diversas/adenomiose-uterina 1 https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/suffering-from-endometriosis-or-adenomyosis-heres-the-difference/photostory/98910929.cms 1 https://drauziovarella.uol.com.br/mulher/adenomiose-causas-sintomas-e-possiveis-tratamentos/ 1 https://www.milann.co.in/blogs/adenomyosis 1 https://drbrunobonilha.com.br/procedimento-adenomiose/ 1 https://www.glamourmagazine.co.uk/article/difference-between-endometriosis-and-adenomyosis 1 https://www.terra.com.br/vida-e-estilo/saude/uma-em-cada-10-mulheres-tem-adenomiose-conheca-endometriose-do-utero,bfd14c8558580242c5ea503a7 9f7eaed0ma8g25v.html 1 https://ferticity.com/endometriosis-adenomyosis-treatment-in-delhi 1 https://clinicabuzzini.com.br/ja-ouviu-falar-em-adenomiose/ 1 https://carnegiewomenshealth.com/blog/the-difference-between-adenomyosis-and-endometriosis/ 1 https://drathaisvazquez.com.br/2023/02/13/adenomiose-o-que-e-isso/ 1 https://www.newlife-ivf.co.uk/blog/what-is-adenomyosis 1 href="https://artmedicina.com.br/utero-com-adenomiose/">https://artmedicina.com.br/utero-com-adenomiose/">href="https://artmedicina.com.br/utero-com-adenomiose/ 1 https://www.fertilitytexas.com/endometriosis-versus-adenomyosis/ 1 https://sogimig.org.br/adenomiose/conteudo-para-pacientes/ 1 https://fertiltree.com/blogs/bulky-uterus/ 1 https://feitoparaela.com.br/2023/04/25/adenomiose-voce-sabe-o-que-e-esta-doenca-que-pode-causar-infertilidade/ 1 https://timesofindia.indiatimes.com/blogs/voices/adenomyosis-causes-and-treatment/ 1 https://drapriscilamatsuoka.com.br/a-adenomiose-pode-virar-cancer-uterino/ 3 https://www.chandigarhayurvedcentre.com/blog/adenomyosis-ayurvedic-treatment/ 1 https://oscarduarte.com.br/adenomiose.html 3 https://womensclinicbtm.com/adenomyosis/ 1 https://unih.clinic/adenomiose-causas-sintomas-e-tratamentos/ 3 https://www.centerofendometriosis.com/blog/endometriosis-vs-adenomyosis-understanding-the-difference/ 1 https://www.tuasaude.com/adenomiose/ 3 https://www.lotusmedics.com.au/blog/adenomyosis-vs-fibroids/ 1 https://www.mdsaude.com/ginecologia/menstruacao/adenomiose/ 3 https://www.prepladder.com/neet-pg-study-material/obstetrics-and-gynaecology/endometriosis-and-adenomyosis-neet-pg 1 https://adrianadegoes.med.br/adenomiose/ 3 https://www.brahmhomeo.com/disease-details/adenomyosis-treatment-in-homeopathy/161 1 https://ipgo.com.br/adenomiose-completo/#:~:text=8%3A27%20pm-,O%20que%20 %C3%A9%20a%20Adenomiose%3F,da%20Zona%20 Juncional%20(ZJ) . 5 https://www.verywellhealth.com/adenomyosis-vs-endometriosis-5248776 3 https://www.shreeivfclinic.com/blogs/what-is-the-meaning-of-adenomyosis/ 3 https://www.indiraivf.com/infertility-problems/adenomyosis 3 https://www.msdmanuals.com/home/women-s-health-issues/miscellaneous-gynecologic-abnormalities/uterine-adenomyosis 3 https://www.theendometriosisfoundation.org/adenomyosis 3 https://www.drharris.com.au/adenomyosis-obstetrician-gynaecologist-perth/ 3 https://www.cosmopolitan.com/uk/body/health/a40252558/adenomyosis-vs-endometriosis/ 3 https://ayu.health/blog/distinguishing-endometriosis-and-adenomyosis-understanding-differences/ 3 https://insixteenyears.com/adenomyosis/ 3 https://www.nhsinform.scot/healthy-living/womens-health/girls-and-young-women-puberty-to-around-25/periods-and-menstrual-health/adenomyosis/ 3 https://my.clevelandclinic.org/health/diseases/14167-adenomyosis 5 https://www.kegel8.co.uk/help-and-advice/adenomyosis 5 https://www.epworth.org.au/our-services/endometriosis-centre/related/adenomyosis 5 https://momotaroapotheca.com/blogs/vaginal-wellness/chronic-pelvic-pain-adenomyosis-symptoms-treatment-diagnosis 5 How to cite link copy function currentDate() { var today = new Date(); var months = ['January', 'February', 'March', 'April', 'May', 'June', 'July', 'August', 'September', 'October', 'November', 'December'] today.setTime(today.getTime()); return today.getDate() + " " + months[today.getMonth()] + " " + today.getFullYear(); } var citation = 'Araújo, Beatriz Piaulino de et al. 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