The diversity of lesion network mapping findings

This paper comments on the lesion network mapping (LNM) framework, which uses lesion location and a normative brain connectome to infer network mechanisms in brain disorders, responding to a prior critique by Van den Heuvel et al. The authors argue that methodological errors and visualization biases in the earlier study affected its conclusions, specifically disputing the claim that LNM maps diverse circumscribed brain changes mostly to one outcome. They state that the earlier study’s conclusion is not supported by its own presented data, but the excerpt does not provide additional quantitative analyses or specific evidence details. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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