Rectal Metastasis from Early-Stage Endometrial Carcinoma Not Associated with Endometriosis: A Case Report and Literature Review

Blagica Krsteska, Vladimir Risteski, Ana Jovceva, Svetozar Antovic, Svetozar Antović
The Kurume medical journal · 2024 · vol. 71(3.4) , pp. 163–166 · doi:10.2739/kurumemedj.ms7134005 · PMID:40518309 · W4411225177
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case report describes rectal metastasis from early-stage endometrial cancer occurring 8 years post-diagnosis in a patient without endometriosis, highlighting the importance of considering gynecologic history in rectal tumor evaluation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This 2024 case report describes a 59-year-old woman who developed a rectal tumor 8 years after initial surgical treatment for stage IA endometrial carcinoma with hysterectomy and bilateral salpingo-oophorectomy. The rectal mass was resected by ultra-low anterior resection, and histology plus immunohistochemistry (CK7, ER, PAX8, and vimentin) supported an endometrial origin; endometriosis was not found. The authors note that a literature review identified only six previously published cases of rectal metastasis/recurrence from endometrial cancer in this context. Limitations are inherent to the single-case design and the small number of reports, and the authors call for further genetic analysis in larger series. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

OBJECTIVE: Endometrial cancer (EC) is the third most common malignancy in woman with excellent prognosis when diagnosed in early-stage. Recurrences are extremely rare in Stage I EC especially in rectum when not associated with endometriosis. We present a case of rectal metastasis from endometrial carcinoma after 8 years of primary diagnosis. A review of the literature showed only 6 published cases. CASE PRESENTATION: Herein we present a 59-year-old woman with a rectal tumor mass. The patient before 8 years was surgically treated for EC Stage IA with bilateral salpingo-oophorectomy and hysterectomy. After ultra-low anterior resection rectum was removed with the tumor. Histology revealed adenocarcinoma with positive immunohistochemistry for CK7, ER, PAX8, Vimentin which confirmed endometrial origin. Endometriosis was not found. CONCLUSION: Although rectum is a rare site of recurrence from endometrial cancer, rectal tumors should be sampled carefully. Previous patient history and positive immunohistochemistry for EC are in favor of recurrent disease. Screening of colorectal carcinoma should be performed in patients with previous gynecologic diagnosis. Further genetic analysis in bigger case series is needed in order to explain the time and the site of recurrence of early-stage endometrial carcinoma.
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Abstract

Summary: Objective: Endometrial cancer (EC) is the third most common malignancy in woman with excellent prognosis when diagnosed in early-stage. Recurrences are extremely rare in Stage I EC especially in rectum when not associated with endometriosis. We present a case of rectal metastasis from endometrial carcinoma after 8 years of primary diagnosis. A review of the literature showed only 6 published cases. Case presentation: Herein we present a 59-year-old woman with a rectal tumor mass. The patient before 8 years was surgically treated for EC Stage IA with bilateral salpingo-oophorectomy and hysterectomy. After ultra-low anterior resection rectum was removed with the tumor. Histology revealed adenocarcinoma with positive immunohistochemistry for CK7, ER, PAX8, Vimentin which confirmed endometrial origin. Endometriosis was not found.

Conclusion

Although rectum is a rare site of recurrence from endometrial cancer, rectal tumors should be sampled carefully. Previous patient history and positive immunohistochemistry for EC are in favor of recurrent disease. Screening of colorectal carcinoma should be performed in patients with previous gynecologic diagnosis. Further genetic analysis in bigger case series is needed in order to explain the time and the site of recurrence of early-stage endometrial carcinoma. © Kurume University School of Medicine Favorites & Alerts Recently viewed articles

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma

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References (11)

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