Proliferative characteristics of eutopic and ectopic endometrium in adenomyosis using AgNOR technology

Proliferative characteristics of eutopic and ectopic endometrium in adenomyosis using AgNOR technology Downloads Adenomyosis is a benign lesion of the uterus, which is characterized by the presence and pathological growth of endometrial glands and stroma in the myometrium. During adenomyosis, endometrial tissue abnormally grown in the myometrium is called ectopic endometrium, and endometrial tissue in the uterine cavity is called eutopic endometrium. Women with adenomyosis may experience abnormal uterine bleeding, dysmenorrhea, dyspareunia, and infertility, although, in one-third of women, the lesion is asymptomatic. Adenomyosis is the most frequently diagnosed pathology after hysterectomy in perimenopausal women due to heavy bleeding or pain. AgNOR is used as an aid for evaluating the proliferative activity of cells. Certain types of studies have demonstrated their effectiveness in differentiating various benign or malignant processes, as well as in determining the histological grade of intraepithelial neoplastic processes. Within the framework of this study, the proliferative activity of the eutopic and ectopic endometrium, as well as their stroma and normal myometrium, was evaluated on archival blocks fixed in formalin and embedded in paraffin (FFPE), diagnosed in cases of adenomyosis, using AgNOR technology. In the studied system, eutopic endometrium - basal endometrium - in both the glandular and stromal components of ectopic endometrium, the highest proliferative activity is manifested in ectopic endometrium, which is why it can probably represent a risk for the development of neoplasms. Downloads Antero MF, Ayhan A, Segars J, Shih IM. Pathology and Pathogenesis of Adenomyosis. Semin Reprod Med. 2020 May 1;38(2–3):108–18. Devlieger R, D’Hooghe T, Timmerman D. 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