The Ameliorative Effect of Lactobacillus Paracasei BEJ01 Against FB1 Induced Spermatogenesis Disturbance, Testicular Oxidative Stress and Histopathological Damage

Fumonisin B1 (FB1) was a possible carcinogenic molecule for humans as classified by the IARC on 2B group. In livestock, it was responsible for several mycotoxicosis and economic losses. Lactobacillus strains, inhabitants of a wide range of foodstuffs as well as our gastro-intestinal tract, were Generally Recognized as Safe (GRAS). Thus, the aim of this work was to evaluate the protective effect of Lactobacillus paracasei (LP) against FB1 induced reprotoxicities including testicular histopathology, sperm quality disturbance and testosterone level reduction. Pubescent mice were divided randomly into four groups as bellow: Group1: Control; Group 2: FB1 (100 µg/kg b.w); Group 3: LP (2× 10 9 CFU/kg b.w); Group 4: LP (2× 10 9 CFU/kg b.w) and FB1 (100 µg/kg b.w) to be then treated for 10 days. After the end of the treatment, animals were sacrificed; the plasma and epididyms and testicles were harvested to the reproductive system studies. Our results highlighted that LP counteracted the harmful effect generated by FB1. Indeed; it induced sperm quality reduction, oxidative stress generation and histological alterations. In conclusion, the used strain was able to prevent FB1-reproductive system damages of in balb/c mice and could be valorised as an anti-cating agent in animal FB1-contaminated diet.