Identification of key molecules and significant signaling pathways in LINC00958 mediated endometrial cancer cells

Endometrial cancer is the most common gynecologic cancer in the United States. Since the cancers of the same stage and histology have very distinct molecular and genomic profiles, the therapy is quite limited. Current Long noncoding RNAs (lncRNAs) LINC00958 showed some benefit to this cancer, but the mechanism is unknown. In this study, we aim to identify the key molecules and signaling pathways by analyzing the RNA-seq data. The GSE198619 was created by the DNBSEQ-T7 (Homo sapiens). The KEGG and GO analyses indicated "Human T − cell leukemia virus 1 infection" and "Hippo signaling pathway" were the main affected biological processes. Moreover, we further figured out several interactive genes including CDK1, CDC42, JUN, FOS, CCNA2, KIF11, CCND1, KAT2B, MAD2L1, and NRAS. Our study may benefit the study of endometrial cancer treatment.