The pentraxin 3 level profile of ovarian follicle fluid in infertile patients with endometriosis

Wisnumurti D.P., Primariawan RY, Hendy Hendarto, 090315218 D
2012 · W6995780059
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This study found significantly higher Pentraxin-3 levels in the ovarian follicle fluid of infertile women with severe endometriosis compared to those with mild disease or no endometriosis.

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This study investigated the concentration of pentraxin 3 within the ovarian follicle fluid of infertile women diagnosed with endometriosis. The researchers compared these levels against those found in control groups to assess the potential role of this inflammatory marker in endometriosis-associated infertility. The findings indicated that pentraxin 3 levels were significantly altered in the follicular environment of affected patients, suggesting a link between local inflammation and reproductive dysfunction. This paper is centrally about endometriosis — specifically examining biomarkers in the ovarian follicle fluid of infertile patients with the condition.

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Abstract

Endometriosis gives the most proportion as the cause of infertility. One of the factor in endometriosis suspected to be the cause of infertility is the decrease of oocyte quality, which is determined by cumulus expansion. Cumulus cell expansion indirectly causes the production of hyaluronic acid (HA), prostaglandin E2 (PGE2), pentraxin (PTX3), and tumor necrosis factor alpha-induced protein 6 (TNF-aIP6). The objective of this study was to prove the difference in Pentraxin3 level of ovarian follicle fluid in infertile patients with severe stage endometriosis, mild stage endometriosis and without endometriosis. This study was held in Fertility Clinic of Graha Amerta dr. Sutomo Hospital, Surabaya, and Biochemistry Laboratory of Science Faculty Brawijaya University, Malang. This study was an analytic-observational study in human with cross-section study design on follicle fluid samples by observing and measuring the variable from study subject follicle fluid of infertile women that is diagnosed using laparoscopy. The measurement of Pentraxin-3 level on ovarian follicle fluid was done by ELISA. We obtained 300 samples based on laparoscopic findings, The sample were categorized into three groups: Non-endometriosis infertile/control, mild endometriosis infertile and severe endometriosis infertile. The total mean PTX level was -3 3.96 ± 2.71 ng/ml. With the level of PTX-3 on control group 1.21 ± 0.23 ng/ml, mild endometriosis 3.47 ± 0.38 ng/ml, and severe endometriosis 7.21 ± 1.73 ng/ml. Correlation analysis between Pentraxin-3 level with endometriosis severity rs = 0.943 and p = 0.001, showed high correlation. In conclusion, the more severe endometriosis is the level of Pentraxin-3 is also higher. (MOG 2012;20:8-13)
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The pentaxin 3 level profile of ovarian follicle fluid in infertile patients with endometriosis by Hendy Hendarto Submission date: 01-Mar-2019 11:58AM (UTC+0800) Submission ID: 1085783984 File name: 22._The_Pentaxin_3.pdf (132.32K) Word count: 3666 Character count: 19703 8 % SIMILARITY INDEX 6 % INTERNET SOURCES 4 % PUBLICATIONS 1 % STUDENT PAPERS 1 2 % 2 2 % 3 1 % 4 1 % 5 < 1 % 6 < 1 % 7 The pentaxin 3 level profile of ovarian follicle fluid in infertile patients with endometriosis ORIGINALITY REPORT PRIMARY SOURCES www.journal.unair.ac.id Internet Source repository.unair.ac.id Internet Source A RAJKOVIC. "Follicular DevelopmentMouse, Sheep, and Human Models", Knobil and Neill s Physiology of Reproduction, 2006 Publication Mafra, F.A.. "Luteinizing hormone @b-subunit gene (LH@b) polymorphism in infertility and endometriosis-associated infertility", European Journal of Obstetrics and Gynecology, 201007 Publication dspace.lboro.ac.uk Internet Source www.lcrcientifica.com Internet Source id.123dok.com Internet Source < 1 % 8 < 1 % 9 < 1 % 10 < 1 % 11 < 1 % Exclude quotes On Exclude bibliography On Exclude matches Off Ortega-Hernandez, O.D.. "The Long Pentraxin 3 and Its Role in Autoimmunity", Seminars in Arthritis and Rheumatism, 200908 Publication www.medun.acad.bg Internet Source www.frontiersin.org Internet Source X. He. "Long pentraxin 3 in pulmonary infection and acute lung injury", AJP Lung Cellular and Molecular Physiology, 02/02/2007 Publication FINAL GRADE /100 The pentaxin 3 level profile of ovarian follicle fluid in infertile patients with endometriosis GRADEMARK REPORT GENERAL COMMENTS Instructor PAGE 1 PAGE 2 PAGE 3 PAGE 4 PAGE 5 PAGE 6

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