O-235 Techniques and outcomes of fertility preservation in patients with endometriosis

In: Human Reproduction · 2024 · vol. 39(Supplement_1) · doi:10.1093/humrep/deae108.278 · W4400308235
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Abstract

use, those with PPI use had higher rates and risks of any infection (49.7% vs 36.8%;adjusted RR 1.30, mild infection (20.9% vs 16.1%; adjusted RR 1.30,, moderate to severe infection (23.4% vs 15%; adjusted RR 1.47,, and infection-related pregnancy complications (11.2% vs 9.2; adjusted RR 1.12, 95%CI 1.09-1.15).Conclusion: Our results show an association between PPI use and an elevated risk of infection in pregnant women.Next steps include the further investigation into the infection types.PPI therapy has benefits and drawbacks that should be carefully weighed, especially in patients who are prone to infections.While our study highlights potential concerns, it does not imply that all pregnant women are at increased risk.More research is needed to understand the underlying mechanisms and assess potential preventive measures.Prescribing PPIs during pregnancy should be determined on a caseby-case basis, considering the patient's individual health state.We acknowledge the necessity for caution, particularly in vulnerable populations, and more research is needed to demonstrate clinical correlations.Limitations, reasons for caution: Potential confounding by indication due to underlying morbidities cannot be fully accounted for.Further research is required to establish clinical connections.Wider implications of the findings: Clinicians should carefully weigh the benefits of PPI therapy during pregnancy, particularly in patients prone to infections.

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endometriosis

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