Different Ovarian Stimulation Protocols in 164 Patients with Poor Ovarian Response

Objective: To analyse the clinical characteristics of those patients with poor ovarian response(POR) diagnosed according to the Bologna Criteria in IVF-ET, and compare the clinical outcomes of different ovarian stimulation protocols, so as to evaluate therapeutic schedules for POR patients. Methods:The clinical data of 186 cycles in 164 patients undergone IVF-ET in our center from December 2010 to October 2012 were retrospectively analyzed. Those cycles were divided into 3 groups according to ovarian stimulation protocols: the long Gn RHa protocol group(186 cycles), the short Gn RHa protocol group(41 cycles) and the mini-stimulation protocol group(59 cycles). The clinical characteristics and outcomes were compared among three groups.Results:In 164 patients, 112 patients(68.3%) were aged 40, 21 cases(12.8%) suffered from endometriosis and 5 cases(3%) pelvic tuberculosis, while 28 cases(17.1%) had the pelvic operation history. The days and the amounts of Gn in the mini-stimulation protocol group were significantly less than those in other two groups(P0.05). The mean number of collected oocytes in the mini-stimulation protocol group was significantly lower than that in the long Gn RHa protocol group, and the rate of frozen embryos was significantly higher(both P0.05);but there were not significant differences between the mini-stimulation protocol group and the short Gn RHa protocol group(both P0.05). Conclusions:The mini-stimulation protocol is an preferable option for POR patients.