Maternal and Live-birth Outcomes of Intrahepatic Cholestasis of Pregnancy after in vitro fertilization

Background: Intrahepatic cholestasis of pregnancy (ICP) is an idiopathic disease of pregnancy while knowledge about ICP after IVF outcomes is scarce, especially the exact maternal characteristics and pregnancy outcomes. Our aim is to evaluate the impact of in vitro fertilization (IVF) on the perinatal outcomes of intrahepatic cholestasis of pregnancy. Methods: A retrospective study of 242 patients with intrahepatic cholestasis of pregnancy enrolled between 2019–2021 was carried out. Data were analyzed from the medical archives of the Huazhong university of science and technology, Tongji Hospital. The data analysis was conducted with SPSS 20.0 statistical software, results below 0.05 indicated significance. Results: Numerical values of transaminases (ALT, AST) and TBA are significantly lower in the IVF group than that in the SC group (p < 0.05). The incidence of GDM was higher in the IVF group than in SC group (30.6% vs 16%, p < 0.05). The cesarean section rates are higher in the IVF group (97.2% vs 85.4%, p < 0.05). On the other hand, the prevalence of premature rupture of membranes was higher in the SC group (10.7%) while none was reported in the IVF-ICP group. Other maternal comorbidities and neonatal outcomes were similar between the two groups. Conclusion: ICP patients who underwent IVF did not experience adverse pregnancy outcomes compared with those who conceived spontaneously. Given that there was no significant difference in prognosis and stillbirth incidence in the third trimester for IVF women with ICP, we suggest following the routine management.