Renal Amyloidogenic Leukocyte Chemotactic Factor 2 Combined with Immunoglobulin A Nephropathy: 2 Case Reports and literature review

Abstract Amyloidogenic leukocyte chemotactic factor 2 (ALECT2) is a recently discovered pathological type of amyloidosis that primarily affects the kidney. Though immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease in China, the coexistence of IgAN and ALECT2-associated renal amyloidosis has rarely been reported. Herein, we present 2 patients with renal ALECT2 amyloidosis and mesangial IgA deposition. After traditional proteinuria reduction therapy, their serum creatinine increased slightly along with stable proteinuria. In conclusion, the management of renal ALECT2 amyloidosis in conjunction with IgAN is mostly centered on managing IgAN.