Effect of CLIMEN~? Combined with Leuprorelin Acetate in the Treatment of Endometriosis and Its Effect on Serum Flk-1,VEGF and Long-term Recurrence

OBJECTIVE To investigate the effect of CLIMEN? combined with leuprorelin acetate in the treatment of endometriosis and the effect on serum flk-1,VEGF and long-term recurrence.METHODS 140 patients with endometriosis who were treated in our hospital from January 2016 to December 2018 were divided into 2 groups according to the random number table,70 cases in each group.Group A patients were treated with leuprorelin acetate,group B patients were treated with CLIMEN? combined with leuprorelin acetate.After 6 months of treatment,the therapeutic effect, sex hormone level,symptoms,serum Flk-1,VEGF level of the two groups were observed.RESULTS The effective rate of group B was significantly higher than that of group A,and the recurrence rate was significantly lower than that of group B（P<0.05）.After treatment,E2,LH,FSH,EMAb,CA125 levels,endometrial thickness and Kupperman scores of the two groups were all improved,and the improvement of group B was significantly better than that of group A（P<0.05）.After treatment,the levels of VEGF,flk-1,il-6 and il-8 in the two groups decreased significantly,and the reduction in group B was significantly lower than that in group A（P<0.05）.Adverse reactions in group B were significantly lower than those in group A（P<0.05）.CONCLUSION CLIMEN? combined with leuprorelin acetate has a good therapeutic effect on endometriosis,with a low recurrence rate.It can significantly improve the hormone level of the body,reduce the levels of VEGF,flk-1,il-6 and il-8,and has fewer adverse reactions,so it can be widely used in clinical practice.