MODERN DIAGNOSTICS, ETIOPATHOGENETIC ASPECTS, AND STRATEGIC DIRECTIONS OF COMPLEX THERAPY FOR ENDOMETRIOSIS IN WOMEN OF REPRODUCTIVE AGE

MODERN DIAGNOSTICS, ETIOPATHOGENETIC ASPECTS, AND STRATEGIC DIRECTIONS OF COMPLEX THERAPY FOR ENDOMETRIOSIS IN WOMEN OF REPRODUCTIVE AGE Authors/Creators - 1. Kokand University, Andijan Branch, Faculty of Medicine, General Medicine, Student of Group 113 Description This fundamental research paper is dedicated to one of the most pressing and socio-medical challenges in modern gynecology, reproductology, and endocrinology—endometriosis pathology. The article provides a fundamental analysis of the molecular-biological basis, hormonal-metabolic dysfunctions, epigenetic modifications of the disease, and their pathological impact on various systems of the female organism. Within the framework of the study, the latest achievements of the obstetric-gynecological schools of the Republic of Uzbekistan are examined, specifically the principles of organ-preserving minimal invasive (laparoscopic) surgery, long-term anti-proliferative hormonal therapy, immunomodulation, and the integrated model of postoperative psycho-social rehabilitation. The primary objective of the research is to improve the methodology for early (pre-clinical) detection of endometriosis in reproductive-aged women presenting with chronic pelvic pain, various degrees of infertility, and hormonal imbalance. Additionally, the article is enriched with scientifically grounded statistical data regarding differential diagnosis algorithms, modern tumor markers (CA-125, HE4), and the pharmacological efficacy of hormonal modulators. The results demonstrate the superiority of innovative diagnostic-therapeutic approaches in preserving the fertile health of women in the conditions of Uzbekistan. Files 470-472.pdf Files (197.3 kB) | Name | Size | Download all | |---|---|---| | md5:6310079259bd059fad55a8faac61ce42 | 197.3 kB | Preview Download | Additional details References - 1. Ayupova F.M. Gynecology: Textbook for Higher Medical Institutions. Tashkent: "Yangi asr avlodi", 2021. – 450 p. - 2. Kurbanova Z.Sh. "Immunological Dysfunctions of Endometriosis and Their Pathogenetic Significance." Surgery of Uzbekistan Journal, 2022. No. 2. pp. 15-25. - 3. Negmatullaeva M.N. "Coexistence of Endometriosis and Metabolic Syndrome in Reproductive-Aged Women." Bulletin of the Bukhara State Medical Institute, 2023. No. 4. pp. 30-40. - 4. Sultonov S.N. Laparoscopy in Operative Gynecology: A Practical Guide. Tashkent: "Abu Ali ibn Sino", 2020. – 300 p. - 5. Ahmedov F.K. "Analysis of the Quality of Life in Patients with Endometriosis." A New Day in Medicine Journal, 2024. No. 1. pp. 110-120.