Effects of PKF 115–584 on total and active forms of MMP-2 and MMP-9.

Sachiko Matsuzaki (405488), Claude Darcha (405489)
2015 · doi:10.1371/journal.pone.0061690.g009 · W6904259042
other OA: green CC0
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The study investigated the in vitro effects of PKF 115–584, a small-molecule antagonist of the Tcf/ß-Catenin complex, on endometrial and endometriotic cells derived from patients with endometriosis. Researchers analyzed the levels of total and active matrix metalloproteinases MMP-2 and MMP-9 in both epithelial and stromal cells after treatment with the compound. The results indicated significant changes in these protease forms in response to the antagonist, highlighting its potential impact on cell behavior associated with the disease. This paper is centrally about endometriosis — specifically examining molecular mechanisms involving matrix metalloproteinases in endometriotic tissue samples.

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Abstract

A, B: Total and active forms of MMP-2 in non-treated and PKF 115–584–treated epithelial (A) and stromal (B) cells of endometriotic tissue and matched eutopic endometrium of patients with endometriosis. C, D: Total and active forms of MMP-9 in non-treated and PKF 115–584–treated epithelial (C) and stromal (D) cells of endometriosis and matched eutopic endometrium of patients with endometriosis. Values are normalized to the total protein content of the culture supernatants. Results are presented as the mean +SEM. Endo: endometriosis, EE: matched eutopic endometrium. Endo: (epithelial cells: n = 6, stromal cells: n = 6). EE: (epithelial cells: n = 6, stromal cells: n = 6). a: p<.05 versus PKF 115–584–treated endometrial epithelial or stromal cells.
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In Vitro Effects of a Small-Molecule Antagonist of the Tcf/ß-Catenin Complex on Endometrial and Endometriotic Cells of Patients with Endometriosis Figure 9 Effects of PKF 115–584 on total and active forms of MMP-2 and MMP-9. A, B: Total and active forms of MMP-2 in non-treated and PKF 115–584–treated epithelial (A) and stromal (B) cells of endometriotic tissue and matched eutopic endometrium of patients with endometriosis. C, D: Total and active forms of MMP-9 in non-treated and PKF 115–584–treated epithelial (C) and stromal (D) cells of endometriosis and matched eutopic endometrium of patients with endometriosis. Values are normalized to the total protein content of the culture supernatants. Results are presented as the mean +SEM. Endo: endometriosis, EE: matched eutopic endometrium. Endo: (epithelial cells: n = 6, stromal cells: n = 6). EE: (epithelial cells: n = 6, stromal cells: n = 6). a: p<.05 versus PKF 115–584–treated endometrial epithelial or stromal cells.

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endometriosis

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