Agreement of Corneal Aberrometry Between a New Pyramid Wavefront Aberrometer and a Scheimpflug-Based System

Agreement of Corneal Aberrometry Between a New Pyramid Wavefront Aberrometer and a Scheimpflug-Based System | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Agreement of Corneal Aberrometry Between a New Pyramid Wavefront Aberrometer and a Scheimpflug-Based System Armin Doostparast, Maryam Ghandhari, Amir Hossein Khosronejad, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6896532/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose: To compare corneal aberrometry between Pentacam HR, a Scheimpflug-based imaging system, and Peramis, an aberrometer that combines a pyramidal wavefront sensor with Placido-disk topography. Methods: Bilateral eyes of 111 healthy participants were included. Corneal aberration terms—including total aberrations (TAs), lower-order aberrations (LOAs), higher-order aberrations (HOAs), trefoil ( \(\:{\text{C}}_{3}^{\pm\:3}\) ), coma ( \(\:{\text{C}}_{3}^{\pm\:1}\) ), and spherical ( \(\:{\text{C}}_{4}^{0}\) ) aberrations—were recorded. The agreement between the systems was assessed using Bland-Altman analysis and two types of intraclass correlation coefficients (ICC): ICC-Abs for absolute agreement and ICC-Cs for consistency. Additionally, the mean measurements were compared. Results: TAs and LOAs demonstrated moderate to good agreement (ICC-Abs and ICC-Cs = 0.66–0.81). Similarly, Coma aberrations showed moderate agreement (ICC-Abs = 0.41–0.64, ICC-Cs = 0.44–0.64). In contrast, HOAs, trefoil, and spherical aberrations showed poor agreement (ICC-Abs ≤ 0.48, ICC-Cs ≤ 0.52). Except for HOAs (P-values = 0.08 and 0.06), there were significant differences between the systems for all aberration terms (P-values < 0.05). Differences were medium for TAs, LOAs, horizontal coma, and spherical aberrations (Hedges = 0.31–0.48) and mostly negligible otherwise. Limits of agreement (LoA) ranges were 1.67 to 2.33 D (diopters) for TAs, 1.68 to 2.33 D for LOAs, 0.61 to 0.69 D for HOAs, 0.76 to 0.86 D for trefoil, 0.70 to 0.82 D for coma, and 0.31 to 0.43 D for spherical aberrations. Conclusions: The Inter-device agreement was moderate to good for TAs, LOAs, and coma aberrations, and poor for HOAs, trefoil, and spherical aberrations. Therefore, these systems should not be used interchangeably for refractive surgery planning or follow-up. Inter-rater reliability agreement consistency aberrometry Peramis Pentacam HR Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6896532","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":490484090,"identity":"c3a388e5-fa2b-4b83-b805-bbfa87bae615","order_by":0,"name":"Armin Doostparast","email":"","orcid":"","institution":"Mashhad University of Medical Sciences","correspondingAuthor":false,"prefix":"","firstName":"Armin","middleName":"","lastName":"Doostparast","suffix":""},{"id":490484091,"identity":"80f93506-e213-4183-9a2c-a15c4a7d8d65","order_by":1,"name":"Maryam Ghandhari","email":"","orcid":"","institution":"Mashhad University of Medical 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Eslampoor","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA60lEQVRIiWNgGAWjYBACezBZAOV9AGI2dgJaDBtApAGEwzgDpIWZgBaDA0hamHnAJCEttw8wPvxhYBdtzt587LPNr23yfMwMjB8+5uDRci6B2ZjHIDl3Z8+x5Nm5fbcN25gZmCVnbsOj5QwDmzSDAXPuhhs5xsy5PbcZgVrYmHnxa2H/+cOgHqLFsue2PTFa2Bh4DA5DtDD8uJ1IUIthD2OzNI/BcbBfGHsbbie3MTM24/WLPQ/zwY8/Kqpzt7M3H2b48ee27fz25oMfPuLRAoy/BogLwew2JBGCABKbf4hTPApGwSgYBSMLAADFPk1B18VRrQAAAABJRU5ErkJggg==","orcid":"","institution":"Mashhad University of Medical Sciences","correspondingAuthor":true,"prefix":"","firstName":"Alireza","middleName":"","lastName":"Eslampoor","suffix":""}],"badges":[],"createdAt":"2025-06-15 05:08:08","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6896532/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6896532/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":89798830,"identity":"9e6bcff0-4df1-4e24-8053-6f02d6c997ca","added_by":"auto","created_at":"2025-08-25 07:39:30","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":725607,"visible":true,"origin":"","legend":"","description":"","filename":"BMCOphthalmologyManuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6896532/v1_covered_598d62dc-d82e-4d66-9dcd-28e9ea95d95f.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Agreement of Corneal Aberrometry Between a New Pyramid Wavefront Aberrometer and a Scheimpflug-Based System","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Inter-rater reliability, agreement, consistency, aberrometry, Peramis, Pentacam HR","lastPublishedDoi":"10.21203/rs.3.rs-6896532/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6896532/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003ePurpose:\u003c/h2\u003e\u003cp\u003eTo compare corneal aberrometry between Pentacam HR, a Scheimpflug-based imaging system, and Peramis, an aberrometer that combines a pyramidal wavefront sensor with Placido-disk topography.\u003c/p\u003e\u003ch2\u003eMethods:\u003c/h2\u003e\u003cp\u003eBilateral eyes of 111 healthy participants were included. Corneal aberration terms\u0026mdash;including total aberrations (TAs), lower-order aberrations (LOAs), higher-order aberrations (HOAs), trefoil (\u003cspan class=\"InlineEquation\"\u003e\u003cspan class=\"mathinline\"\u003e\\(\\:{\\text{C}}_{3}^{\\pm\\:3}\\)\u003c/span\u003e\u003c/span\u003e), coma (\u003cspan class=\"InlineEquation\"\u003e\u003cspan class=\"mathinline\"\u003e\\(\\:{\\text{C}}_{3}^{\\pm\\:1}\\)\u003c/span\u003e\u003c/span\u003e), and spherical (\u003cspan class=\"InlineEquation\"\u003e\u003cspan class=\"mathinline\"\u003e\\(\\:{\\text{C}}_{4}^{0}\\)\u003c/span\u003e\u003c/span\u003e) aberrations\u0026mdash;were recorded. The agreement between the systems was assessed using Bland-Altman analysis and two types of intraclass correlation coefficients (ICC): ICC-Abs for absolute agreement and ICC-Cs for consistency. Additionally, the mean measurements were compared.\u003c/p\u003e\u003ch2\u003eResults:\u003c/h2\u003e\u003cp\u003eTAs and LOAs demonstrated moderate to good agreement (ICC-Abs and ICC-Cs\u0026thinsp;=\u0026thinsp;0.66\u0026ndash;0.81). Similarly, Coma aberrations showed moderate agreement (ICC-Abs\u0026thinsp;=\u0026thinsp;0.41\u0026ndash;0.64, ICC-Cs\u0026thinsp;=\u0026thinsp;0.44\u0026ndash;0.64). In contrast, HOAs, trefoil, and spherical aberrations showed poor agreement (ICC-Abs\u0026thinsp;\u0026le;\u0026thinsp;0.48, ICC-Cs\u0026thinsp;\u0026le;\u0026thinsp;0.52). Except for HOAs (P-values\u0026thinsp;=\u0026thinsp;0.08 and 0.06), there were significant differences between the systems for all aberration terms (P-values\u0026thinsp;\u0026lt;\u0026thinsp;0.05). Differences were medium for TAs, LOAs, horizontal coma, and spherical aberrations (Hedges\u0026thinsp;=\u0026thinsp;0.31\u0026ndash;0.48) and mostly negligible otherwise. Limits of agreement (LoA) ranges were 1.67 to 2.33 D (diopters) for TAs, 1.68 to 2.33 D for LOAs, 0.61 to 0.69 D for HOAs, 0.76 to 0.86 D for trefoil, 0.70 to 0.82 D for coma, and 0.31 to 0.43 D for spherical aberrations.\u003c/p\u003e\u003ch2\u003eConclusions:\u003c/h2\u003e\u003cp\u003eThe Inter-device agreement was moderate to good for TAs, LOAs, and coma aberrations, and poor for HOAs, trefoil, and spherical aberrations. Therefore, these systems should not be used interchangeably for refractive surgery planning or follow-up.\u003c/p\u003e","manuscriptTitle":"Agreement of Corneal Aberrometry Between a New Pyramid Wavefront Aberrometer and a Scheimpflug-Based System","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-07-25 16:33:47","doi":"10.21203/rs.3.rs-6896532/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"9aa5ac94-96aa-4171-8953-6e8ee2cc7043","owner":[],"postedDate":"July 25th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-08-25T07:39:14+00:00","versionOfRecord":[],"versionCreatedAt":"2025-07-25 16:33:47","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6896532","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6896532","identity":"rs-6896532","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}