Dual beam optical coherence tomography angiography for decoupling axial velocity gradient

Dual beam optical coherence tomography angiography for decoupling axial velocity gradient | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Dual beam optical coherence tomography angiography for decoupling axial velocity gradient Zhengyang Xu, Yukun Wang, Xi Chen, Kan Lin, Linbo Liu This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4169714/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 22 Aug, 2024 Read the published version in Scientific Reports → Version 1 posted 12 You are reading this latest preprint version Abstract Axial velocity gradient (AVG) in the optical coherence tomography angiography (OCTA) signal affects measurement accuracy when the flow is not perpendicular to the scanning beam. We developed a dual beam OCTA method to decouple the contribution of AVG from the decorrelation signal. Decoupling is first verified by phantom experiments which reduces measurement uncertainty from 8% to 0.4% (standard deviation). We also tested the method in human skin in vivo and the results indicate that the contribution of AVG to decorrelation signal is reduced. Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 22 Aug, 2024 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 05 Jun, 2024 Reviews received at journal 04 Jun, 2024 Reviews received at journal 13 May, 2024 Reviewers agreed at journal 12 May, 2024 Reviews received at journal 25 Apr, 2024 Reviewers agreed at journal 17 Apr, 2024 Reviewers agreed at journal 17 Apr, 2024 Reviewers invited by journal 15 Apr, 2024 Editor assigned by journal 15 Apr, 2024 Editor invited by journal 05 Apr, 2024 Submission checks completed at journal 05 Apr, 2024 First submitted to journal 26 Mar, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4169714","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":288982433,"identity":"13b63e58-7ca0-4ded-8392-98005a5c85de","order_by":0,"name":"Zhengyang Xu","email":"","orcid":"","institution":"Nanyang Technological University","correspondingAuthor":false,"prefix":"","firstName":"Zhengyang","middleName":"","lastName":"Xu","suffix":""},{"id":288982434,"identity":"97a38646-a0eb-49ee-93d1-ebf0c64f4c94","order_by":1,"name":"Yukun Wang","email":"","orcid":"","institution":"Nanyang Technological University","correspondingAuthor":false,"prefix":"","firstName":"Yukun","middleName":"","lastName":"Wang","suffix":""},{"id":288982435,"identity":"1b0b8733-2918-4a4b-81dc-3456d9422b81","order_by":2,"name":"Xi Chen","email":"","orcid":"","institution":"Nanyang Technological University","correspondingAuthor":false,"prefix":"","firstName":"Xi","middleName":"","lastName":"Chen","suffix":""},{"id":288982436,"identity":"98ecd1b4-6d3a-4bb0-bbec-73d1c87408ad","order_by":3,"name":"Kan Lin","email":"","orcid":"","institution":"Nanyang Technological University","correspondingAuthor":false,"prefix":"","firstName":"Kan","middleName":"","lastName":"Lin","suffix":""},{"id":288982437,"identity":"5a8cf609-0d20-401b-b6b9-ad813126360c","order_by":4,"name":"Linbo Liu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAzElEQVRIiWNgGAWjYBACA/4zZow/2/7I8UP4zERoYeYxY0g8dsxYsoGZJC3PDiduOECilmOJm2/3H5NgqLBObOA/foEILdv+JG67c5hNguFMemKDRE4BMVqOJW67kcwmwdh2GKiFJ4EILfMOJ26eAdLyD6iF/wwxWvqA3pcAaWkAamFIP0BAC1saUMsxY4kbycYWCcfSjdskcvDqYLDvP3z8IzgqZyQ+vPGhxlq2n//4A/x6UADIE2wMPAYkaIEAdlJsGQWjYBSMghEAAO8rSQjtu75tAAAAAElFTkSuQmCC","orcid":"","institution":"Nanyang Technological University","correspondingAuthor":true,"prefix":"","firstName":"Linbo","middleName":"","lastName":"Liu","suffix":""}],"badges":[],"createdAt":"2024-03-26 12:11:57","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4169714/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4169714/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41598-024-68924-4","type":"published","date":"2024-08-22T15:57:03+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":63300034,"identity":"43ee8e07-ed77-4252-9a47-5f584ba18b74","added_by":"auto","created_at":"2024-08-26 16:10:14","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1214318,"visible":true,"origin":"","legend":"","description":"","filename":"DualbeamopticalcoherencetomographyangiographyfordecouplingaxialvelocitygradientZhengyangXuv2.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4169714/v1_covered_e7a58e76-d358-4832-b266-41a7b7176a41.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Dual beam optical coherence tomography angiography for decoupling axial velocity gradient","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4169714/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4169714/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Axial velocity gradient (AVG) in the optical coherence tomography angiography (OCTA) signal affects measurement accuracy when the flow is not perpendicular to the scanning beam. 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