Endocrine Disruptors and Endometriosis Risk
Endometriosis pathogenesis involves hormonal influence, which may be linked to endocrine disruptors' effects on hormone-sensitive tissues.
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This paper reviews evidence on whether endocrine-disrupting chemicals contribute to endometriosis risk, framing endometriosis pathogenesis as involving hormonal influences alongside inflammatory theories. It summarizes findings across environmental epidemiology and mechanistic studies, including associations between in utero or biomarker-based exposure to compounds such as bisphenol A and phthalates (and also dioxin-related pathways) and endometriosis, as well as animal and in vitro data showing estrogenic activity, immune/inflammatory effects, and endometrial receptor changes. A key caveat is that the chapter does not establish a single consensus pathogenic mechanism and synthesizes heterogeneous study designs and exposure measures. This paper is centrally about endometriosis — it specifically reviews endocrine-disruptor exposures (e.g., bisphenol A, phthalates, and dioxin-related factors) and their links to endometriosis risk and pathogenesis.
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References (35)
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