Evaluation of platelet parameters as a marker of preeclampsia: A retrospective case-controlled study

Introduction: Preeclampsia (PE) is characterized by proteinuria and gestational hypertension, and is a leading global cause of maternal mortality and perinatal morbidity. This study aims to investigate the diagnostic value of platelet indices, namely platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), Platelet large cell ratio (P-LCR), platelet to lymphocyte ratio( PLR), and PC/MPV (PLM) in women with preeclampsia . Methods: : Four groups were evaluated: Case group (n=50) including Sever preeclampsia (n=23), mild preeclampsia (n=16), hellp syndrome (n=11) and healthy control group (n=50). Using the same automated blood cell count, platelet parameters were collected. Statistical analysis was conducted by analysis of the variance, t-test, and receiver operational characteristics (ROC) curve. P≤0.05 was considered significant. Results: : MPV, PDW, and RDW were significantly lower and HCT, RBC, PC, PLR, and PLM were significantly higher in the case group. Lower PLR was found in mild preeclampsia compare to severe. Conclusion. The AUC for PC, PLR, and PLM were considered as regular. Therefore, we can suggest that the patients with cut-off values of these parameters should be carefully followed for the development of PE