Limitations in the Use of Combined Gonadotropin Releasing Hormone Analog and Human Menopausal Gonadotropin for In Vitro Fertilization

Zion Ben‐Rafael, Y. Menashe, R. Mimon, Shlomo Lipitz, David Bider, M. Zolti, Uzi Dan, Clara Pariente, J. Shalev, J. Dor, David Levran, S. Mashiach
In: Advances in Assisted Reproductive Technologies · 1990 · pp. 17–29 · doi:10.1007/978-1-4613-0645-0_2 · W105246695
book-chapter OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Combined gonadotropin-releasing hormone analog and human menopausal gonadotropin use in IVF is limited by high cancellation rates (20-40%) mainly due to premature luteinizing hormone surges.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

The paper discusses ovarian stimulation in IVF, focusing on the combined use of a gonadotropin-releasing hormone (GnRH) analog and human menopausal gonadotropin, with attention to premature LH surges as a major cause of cycle cancellation. It states that while stimulation protocols are tailored to patients’ hormonal status, 20–40% of patients are cancelled before ovum pick-up due mainly to premature LH surge, implying important limitations in achieving consistent ovarian control with this approach. A key caveat is that no single agent or dosage is optimal for all patients, so results depend on individual hormonal milieu and protocol adjustment rather than a universally effective regimen. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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