Corticosteroid and Steroid Therapies in PANDAS: A Systematic Review of Efficacy and Safety

Corticosteroid and Steroid Therapies in PANDAS: A Systematic Review of Efficacy and Safety | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 6 February 2025 V1 Latest version Share on Corticosteroid and Steroid Therapies in PANDAS: A Systematic Review of Efficacy and Safety Author : Abdul Musawir Authors Info & Affiliations https://doi.org/10.22541/au.173885025.55312936/v1 361 views 115 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) is characterized by sudden neuropsychiatric symptoms, such as obsessive-compulsive disorder (OCD) and tics, following streptococcal infections. Among the treatments explored, corticosteroids like prednisone have been used for their immunosuppressive effects to reduce inflammation and autoimmune responses. However, the comparison between corticosteroids and other steroid treatments in PANDAS management is still a subject of clinical debate. Corticosteroids tend to provide short-term relief in managing acute flares but are often associated with symptom recurrence post-treatment, making them a less favorable long-term solution. This review evaluates the effectiveness of corticosteroids versus regular steroids, analyzing their role in reducing symptom severity, flare duration, and relapse rates in PANDAS patients. While corticosteroids are widely used for their ability to control inflammation during acute episodes, other steroids may offer varied efficacy and side-effect profiles. The need for further research remains crucial to establishing clearer, long-term treatment guidelines. Supplementary Material File (corticosteroid and steroid therapies in pandas_ a systematic review of efficacy and safety.pdf) Download 91.65 KB Information & Authors Information Version history V1 Version 1 06 February 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords corticosteroids neuroinflammation pandas pediatric neuropsychiatry Authors Affiliations Abdul Musawir Toronto Metropolitan University Faculty of Science View all articles by this author Metrics & Citations Metrics Article Usage 361 views 115 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Abdul Musawir. Corticosteroid and Steroid Therapies in PANDAS: A Systematic Review of Efficacy and Safety. Authorea . 06 February 2025. DOI: https://doi.org/10.22541/au.173885025.55312936/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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