人類輸卵管ノ藥理學的研究
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Abstract
In the previous papers K. Murakami, one of the authors published the results of his pharmacological researches on human uterus and Lig. teres uteri. The present paper deals with the similar studies on the human Fallopian tube. Human isolated tube produces rhythmical automatism by means of Magnus' method. The automatism of this organ is more frequent but somewhat irregular as compared with those of the uterus or the round ligament of uterus. The tube with its peritoneal cover manifests more irregular automatism than a denuded one, and its peritoneal layer alone produces automatism too. Uterine end of the tube shows more marked automatism than its ovarian end. Ovarial cyst or myoma of uterus do not interfere with the automatism of the Fallopian tube of respective individuals so affected, but careinoma of uterus causes decreased automatism of tube. The difference of ages in patient between 16 and 59 years shows no influence on automatism of this organ, and the Status of wether multiparous or nulliparous has no factor in this respect. Adrenalin in low concentration manifests a stimulative action on the tube, while in high concentration it produces stimulative effect in most cases, but sometimes depressive action. This fact suggests us that the sympathetic nerve of this organ has both motor and inhibitory functions. A smoll dose of pilocarpin produces a stimulative action on the tube. The same reaction is recognized in the experiment with acetylcholin. So, it is clearly understood that the parasympathetic nerve in this organ is motor in its function. But pilocarpin in high concentration stimulate the sympathetic inhibitor while acetylcholin in high concentration paralyzes the muscle of the tube, both causing the depressing effect on the automatism of the organ. Physostigmin manifests stimulative effect on the human tube, acting mainly on its muscle. Its action on the parasympathetic nerve can hardly be proved. Atropin shows very inconsistent effect on the tube, but in low concentration, it paralizes parasympathetic nerve, while motor sympathetic nerve is affected by its moderately concentrated solution. Pituitrin acts as inhibitory on the tube by affecting the inhibitory sympathetic nerve. Secacornin in low concentration manifests stimulative action on the tube by affecting muscle, while in high concentration, it causes the depression of automatism by acting on inhibitory fibre of the sympathetic nerve. Barium affects the muscle of the tube and stimulative action is recognized. As it has been mentioned above, actions of adrenalin, pilocarpin, acetylcholin, physostigmin, atropin and barium on the human tube do not vary from the some on the uterus and round ligament, while pituitrin and secacornin show somewhat different actions on those organs.
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ªRçÎ{ðè¶æ44Næ9åj(æ512åj)
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OKAYAMA-IGAKKAI-ZASSHI
Jg. 44. Nr. 9. Sept. 1932.
110.
615.1:611.656
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[ºa7N218úóe]
From the Department of Pharmacology, Okayama University
(Direclor: Prof. Dr. K. Okushima).
Pharmacological studies on the Human Fallopian Tube.
By
Kensuke Murakami and Masayuki Kinoshita.
Received for publication February 18. 1932.
In the previous papers K. Murakami, one of the authors published the results of his
pharmacological researches on human uterus and Lig. teres uteri. The present paper
deals with the similar studies on the human Fallopian tube.
Human isolated tube produces rhythmical automatism by means of Magnus' method.
The automatism of this organ is more frequent but somewhat irregular as compared with
those of the uterus or the round ligament of uterus. The tube with its peritoneal cover
manifests more irregular automatism than a denuded one, and its peritoneal layer alone
produces automatism too.
Uterine end of the tube shows more marked automatism than its ovarian end. Ovarial
cyst or myoma of uterus do not interfere with the automatism of the Fallopian tube of
1
2354@ ºãC,غ³V
respective individuals so affected, but careinoma of uterus causes decreased automatism
of tube. The difference of ages in patient between 16 and 59 years shows no influence
on automatism of this organ, and the Status of wether multiparous or nulliparous has no
factor in this respect.
Adrenalin in low concentration manifests a stimulative action on the tube, while in
high concentration it produces stimulative effect in most cases, but sometimes depre
ssive action. This fact suggests us that the sympathetic nerve of this organ has both
motor and inhibitory functions.
A smoll dose of pilocarpin produces a stimulative action on the tube. The same
reaction is recognized in the experiment with acetylcholin. So, it is clearly understood
that the parasympathetic nerve in this organ is motor in its function. But pilocarpin in
high concentration stimulate the sympathetic inhibitor while acetylcholin in high concent
ration paralyzes the muscle of the tube, both causing the depressing effect on the a
utomatism of the organ.
Physostigmin manifests stimulative effect on the human tube, acting mainly on its
muscle. Its action on the parasympathetic nerve can hardly be proved.
Atropin shows very inconsistent effect on the tube, but in low concentration, it para
lizes parasympathetic nerve, while motor sympathetic nerve is affected by its moderately
concentrated solution.
Pituitrin acts as inhibitory on the tube by affecting the inhibitory sympathetic nerve
Secacornin in low concentration manifests stimulative action on the tube by affecting
muscle, while in high concentration, it causes the depression of automatism by acting on
inhibitory fibre of the sympathetic nerve.
Barium affects the muscle of the tube and stimulative action is recognized.
As it has been mentioned above, actions of adrenalin, pilocarpin, acetylcholin, physo
stigmin, atropin and barium on the human tube do not vary from the some on the uterus
and round ligament, while pituitrin and secacornin show somewhat different actions on
those organs. (Abstract).
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1) ºã,ªçÎè¶,æ42N,1813Å,ºa5N. 2)º ã,ª çÎè¶,æ42N,3081Å,ºa5N.
3)º ã.ª çÎè¶,æ43N,1485Å,ºa6N. 4)Kehrer, Arch. f. Gynakol. Bd. 81, S. 160, 1906.
5)û¸ ´,ß EwlÈ{ðXñ,æ1åj,367Å,å³8N. 6) Î,ß EwlÈ{ðXñ,æ9ª,
125Å,å³15N. 7)~ c, sçÎ{è¶,æ20ª,1405Å,å³12N. 8)¡ c,ª çÎè¶,æ
39N,2025Å,ºa2N. 9)´ {,© NçÎ{ðè¶,1087Å,ºa3N 10) Rubsamen u. Kliger
mann, Zeitschr. f. Geb. u. gyn. Bd. 71, S. 272, 1912. 11) Lieb, Americ. Journ. of Obst. Vol. 71, No
. 2, p. 209, 1915. 12) Gunn. Zit. nach Sollmann's Pharmacology. p. 343. 13) Kok, Zentralbl. f.
Gyn. Nr, 42, 1927.
14
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