IL-6 Levels in Endometriosis and Ovarian Cancer: A Review Supporting Malignant Transformation

John Coté, Robert Côté, K. Kennedy
In: Obstetrics & Gynecology · 2026 · vol. 147(4S) , pp. 96S · doi:10.1097/aog.0000000000006210.29 · W7139947500
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This review explores the role of IL-6 in endometriosis and ovarian cancer, proposing its involvement in the malignant transformation of endometrial tissue.

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This review article examines the potential link between interleukin-6 (IL-6) levels and the malignant transformation of endometriosis into ovarian cancer. The authors analyze existing literature to support the hypothesis that chronic inflammation driven by IL-6 may contribute to this pathological progression. By synthesizing data on inflammatory markers, the paper highlights the biological plausibility of endometriosis serving as a precursor lesion for certain types of ovarian malignancies. This paper is centrally about endometriosis — specifically its association with ovarian cancer risk through inflammatory pathways.

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SGS Abstracts Supplement: Non-discussed Poster 29IL-6 Levels in Endometriosis and Ovarian Cancer: A Review Supporting Malignant TransformationCoté, J.1; Coté, R.2; Kennedy, K.3 Author Information 1Creighton University School of Medicine/CHI/CommonSpirit Health 2Creighton University 3Creighton University School of Medicine Obstetrics & Gynecology 147(4S):p 96S, April 2026. | DOI: 10.1097/AOG.0000000000006210.29 Buy © 2026 by the American College of Obstetricians & Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.

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endometriosis

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