Redefining Ovarian Fibrosis Through Comparative Analysis of Collagen Architecture

Short abstract Ovarian fibrosis is a known pathology of reproductive aging, becoming a growing concern for infertility and complex ovarian diseases. In research, mouse and human ovary samples are utilized, though distinct differences between species warrant validation of architectural phenotypes to accurately define its pathology. Using polarized light microscopy and orientation analysis of collagen fibers in mouse and human ovaries, we define ovarian fibrosis as the accumulation and/or anisotropic organization of fibrillar collagen within the ovarian stroma and/or cortex. Competing Interest Statement The authors have declared no competing interest. Funder Information Declared Natural Sciences and Engineering Research Council of Canada, RGPIN-2024-04509 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.